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citations
Cited by 421 publications
(337 citation statements)
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References 36 publications
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“…It should also be highlighted that little is known about phenolic compound bioactive forms in vivo (achievable concentrations in the circulation aer ingestion as well as the possibility of metabolism) and the mechanisms by which they may contribute toward disease prevention. 32 …”
Section: Composition In Hydrophilic Compoundsmentioning
confidence: 99%
“…It should also be highlighted that little is known about phenolic compound bioactive forms in vivo (achievable concentrations in the circulation aer ingestion as well as the possibility of metabolism) and the mechanisms by which they may contribute toward disease prevention. 32 …”
Section: Composition In Hydrophilic Compoundsmentioning
confidence: 99%
“…It has been reported that peak plasma concentrations of phenolic acids from beer were attained 30 and 60 min after beer ingestion (73). A number of works have shown that phenolic acids are not degraded in the gastrointestinal tract prior to absorption (72)(73)(74)(75)(76)(77)(78)(79)(80)(81). Moreover, free phenolic acids are easily released from foods in the gastrointestinal tract by bacterial esterases (82) and directly absorbed, as early as in the proximal part of the small intestine (71,73).…”
Section: Phenolic Acids As Efficient Ache and Bche Inhibitorsmentioning
confidence: 99%
“…After in vivo absorption, phenolic acids are transformed only to a limited extent in comparison to more complex phenolic compounds (73)(74)(75)(76)81). Polyphenols are easily degraded to simple phenolic compounds, yielding phenolic acids that are absorbed into the blood circulation system (79,80,(83)(84)(85).…”
Section: Phenolic Acids As Efficient Ache and Bche Inhibitorsmentioning
confidence: 99%
“…L. monocytogenes, P. aeruginosa and E. cloacae were the most susceptible bacteria while M. flavus was the most resistant one. CAM revealed higher activity than streptomycin against almost all the bacteria except for S. aureus, B. cereus and M. flavus, and also higher activity than ampicillin for all the bacteria except 11 for M. flavus. CA presented an excellent antibacterial activity against all the bacteria, and higher than its derivative, CAM, and much higher than the two standards.…”
Section: Antibacterial Activitymentioning
confidence: 89%
“…Glucuronidation and methylation appears as prevalent metabolic pathways for phenolic acids in humans. 11 4 So, despite dietary phenolic compounds being widely considered to contribute to health benefits in humans, little is known about the bioactive forms in vivo and the mechanisms by which they may contribute toward disease prevention. In fact, despite the available data concerning antimicrobial effects of phenolic acids, [12][13][14] studies dealing with the antimicrobial activity of their metabolites or derivatives are scarce.…”
Section: Introductionmentioning
confidence: 99%