The Mediterranean Red Alga Asparagopsis: A Source of Compounds against Leishmania

Genovese, Giuseppa; Tedone, Laura; Hamann, Mark T.; Morabito, Marina

doi:10.3390/md7030361

Cited by 80 publications

(50 citation statements)

References 22 publications

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“…Antileishmanial effects had already been reported for extracts from the red alga Asparagopsis taxiformis [25]. The present work extends these findings by showing that ethanolic crude extracts have a powerful action against Leishmania infantum, the prevalent species in the Mediterranean basin.…”

Section: Discussionsupporting

confidence: 77%

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Effectiveness of red alga Asparagopsis taxiformis extracts against Leishmania infantum

et al. 2015

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Section: Discussionsupporting

confidence: 77%

“…antiprotozoal properties [23][24][25][26][27][28][29] Thalli were manually cleaned and stored at -20°C. Crude extracts were obtained with ethanol at room temperature and dried by Rotavapor® at low temperature (35°C) to prevent volatile compounds from evaporation.…”

Section: Cell Sensitivity Assays: the Mtt Assaymentioning

confidence: 99%

Effectiveness of red alga Asparagopsis taxiformis extracts against Leishmania infantum

et al. 2015

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“…Majority of the active antioxidant compounds are flavonoids, isoflavones, flavones, anthocyanins, coumarins, lignans, catechins, and isocatechins. In addition, vitamins C and E, β-carotene, and -tocopherol present in natural foods, are known to possess anticancer potential (Abou-Elella and Ahmed, 2015;Genovese et al, 2012). Thus, potential antioxidant, antiinflammatory, and anticancer properties of plant extracts (or isolated products of plant origin) can possibly be explored for developing the anticancer drugs.…”

Section: Discussionmentioning

confidence: 99%

Determination of antioxidant and anti-inflammatory activities, as well as in vitro cytotoxic activities of extracts of Anastatica hierochuntica (Kaff Maryam) against HeLa cell lines

Abou-Elella¹,

Hanafy²,

Gavamukulya³

2016

J. Med. Plants Res.

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Anastatica hierochuntica L. is distributed throughout the Arabian Peninsula, and North Africa. It is locally called "Kaff Maryam". All parts of the plant are used in folk medicine. This study aimed to investigate possible antioxidant activity of various extracts of Kaff Mariam, anti-inflammatory activities, as well as in vitro cytotoxic activities. Five extract types were used, namely, the whole ethanolic extracts, ethyl acetate, petroleum ether, water, and butanol extracts. The explored items included determination of total phenolics using the Folin-Ciocalteu assay and total flavonoids using Muller's method, anti-oxidant activity using three assays (2, 2'-Azinobis [3-ethylbenzothiazoline-6-sulfonic acid]-diammonium salt (ABTS), reducing power, and 2, 2-diphenyl-1-picrylhydrazyl (DPPH)), membrane stabilization test for anti-inflammatory studies, as well as in vitro cytotoxic activities against HeLa cell lines using the 3-(4, 5-dimethylthiozol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The results obtained indicated high flavonoid and phenolic contents in all the five extracts types. All extracts registered high antioxidant activity using three assays, but generally, the ABTS assay recorded the highest antioxidant activity as compared to the reducing power and DPPH methods. The membrane stabilization test showed that extracts of Kaff Maryam had good anti-inflammatory activity. Extracts of Kaff Maryam also registered very good cytotoxic activities against HeLa cell lines. Kaff Maryam extracts have good antioxidant, anti-inflammatory, and cytotoxic activities and the results of this study provide the basis for further investigation of Kaff Maryam for potential identification of novel bioactive compounds with therapeutic properties.Key words: Anastatica hierochuntica, Kaff Maryam, antioxidant, anti-inflammatory, HeLa cell lines, cytotoxicity. INTRODUCTIONThere is a global increase in the use of medicinal plants for health reasons. In developing countries, herbal drugs and traditional remedies are relatively more popular, because of cultural acceptability and belief that being natural, they are safe and non-toxic. Although, there are some new approaches to drug discovery, such as combinatorial chemistry and computer based molecular modeling design, none of them can replace the 78 J. Med. Plants Res.importance of natural products in drug discovery and development (Gavamukulya et al., 2015;Heinrich and Bremner, 2006;Thirumal et al., 2012). Many synthetic drugs cause severe side effects that are not acceptable except as treatments of last resort for terminal diseases, such as cancer and the metabolites discovered in medicinal plants may avoid the side effect of synthetic drugs (Valko et al., 2007), because ideally, toxicity of such drugs is yet not well understood (Barnes et al., 2007;Salah et al., 2011). The medicinal values of these plants lie in their phytochemical components which produce definite physiological actions on the human body. The most important of these components are alkaloids, tannins, flavono...

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“…However, seaweeds have not been receiving appropriate attention in the past and the availability of algal pharmaceutical data is still scarce compared to that of terrestrial plants [26]. Previous investigation in order to measure the antileishmanial potential from marine algae is extremely limited, being restricted to some species with the test organisms Leishmania donovani [7,27], L. maxicana [6], L. major [9], and L. amazonensis [8], while studies on the Mediterranean species L. infantum are still missing.…”

Section: Discussionmentioning

confidence: 99%

Bioactivity of Phycocolloids against the Mediterranean Protozoan Leishmania infantum: An Inceptive Study

et al. 2016

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Sulfated polysaccharides from marine macroalgae have been shown to possess a variety of biological activities against fungi, bacteria, viruses, and protozoa. In this study, the in vitro activity of algal polysaccharides against Leishmania infantum (Kinetoplastida: Trypanosomatidae) was investigated. The polysaccharides were extracted from different macroalgae of the Mediterranean Sea: Chaetomorpha linum, Agardhiella subulata, Gracilaria viridis, Gracilaria bursa-pastoris, Hypnea cornuta, Sargassum muticum, and Undaria pinnatifida. Preliminary results showed a good anti-leishmanial activity of the investigated species, encouraging the focus on their use as natural resources in order to match integrated management strategies for the employment of local macroalgae.

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The Mediterranean Red Alga Asparagopsis: A Source of Compounds against Leishmania

Cited by 80 publications

References 22 publications

Effectiveness of red alga Asparagopsis taxiformis extracts against Leishmania infantum

Effectiveness of red alga Asparagopsis taxiformis extracts against Leishmania infantum

Determination of antioxidant and anti-inflammatory activities, as well as in vitro cytotoxic activities of extracts of Anastatica hierochuntica (Kaff Maryam) against HeLa cell lines

Bioactivity of Phycocolloids against the Mediterranean Protozoan Leishmania infantum: An Inceptive Study

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