The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review

He, Jian-Ming; Mu, Quanquan

doi:10.1016/j.jep.2015.09.013

Cited by 64 publications

(41 citation statements)

References 55 publications

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“…Data from different studies suggest that plant species of genus Mahonia may have significant anti-cancer potential as well as isolated compounds from plants of The alkaloids are the major secondary metabolites of Mahonia species and it is assumed that they are responsible for most of the properties shown by the plants of this genus (He and Mu, 2015). Berberine and other alkaloids of this type are organic cations, which exhibit antimicrobial, anti-cancer, and antimutagenic activities.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis

Damjanović

Zdunić²,

Šavikin³

et al. 2016

Bangladesh J Pharmacol

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The cytotoxicity of Mahonia aquifolium ethanol and water extracts was examined using MTT test. The morphological changes were analyzed by fluorescence microscopy. Cell cycle distribution and possible activation of caspase-dependent pathway of cell death were assessed by flow cytometry. The effects of ethanol and water extracts on migration of endothelial EA.hy926 cells were analyzed by in vitro scratch assay and inhibition of angiogenesis was detected using tube formation assay. Both extracts demonstrated cytotoxic effects on cancer cell lines with very high selectivity. Morphological evaluation indicated apoptosis. These results were confirmed with cell cycle analysis, where there was accumulation of cancer cells in the subG1 phase. Ethanol and water extracts induced a caspase-dependent apoptosis in HeLa cells through activation of caspase-3 and caspase-8. Both extracts showed the ability to inbibit the migration of EA.hy926 cells and initial steps of angiogenesis. In addition, ethanol extract exerted significant anti-angiogenic effect.Video Clip:<a href="https://www.youtube.com/v/_b1LobagxyA">Cell seeding</a>: 2 min 26 sec<a href="https://www.youtube.com/v/LZrwdyvFAyI">4 hours after treatment of MTT-SDS applied</a>: 54 sec<a href="https://www.youtube.com/v/a6Dshdsg8TY">72 hours after treatment MTT applied</a>: 1 min 8 sec<a href="https://www.youtube.com/v/RE_SH-CauRU">Day 2 treatment</a>: 1 min 32 sec<a href="https://www.youtube.com/v/l4E1y0lgrAE">Measuring absorbance</a>: 9 sec

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Section: Discussionmentioning

confidence: 99%

Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis

Damjanović

Zdunić²,

Šavikin³

et al. 2016

Bangladesh J Pharmacol

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“…Berberis vulgaris is a shrub that produces acidic, edible barberries. The plant has been used in herbal medications due to the antiinflammatory, antimicrobial, and antioxidant properties of its isoquinoline alkaloid, berberine . A double‐blind, randomized, placebo‐controlled trial evaluated the efficacy of oral gelatin capsules containing aqueous extract of dried barberry (600 mg daily for 4 weeks) in adolescents aged 12‐17 years with moderate‐to‐severe acne .…”

Section: Oral Supplementsmentioning

confidence: 99%

“…The plant has been used in herbal medications due to the antiinflammatory, antimicrobial, and antioxidant properties of its isoquinoline alkaloid, berberine. 51 53 Only one study of barberry and Gugulipid involving pediatric patients was identified, and further studies on safety and efficacy are needed to guide clinical recommendations related to these compounds.…”

Section: Or Al Supplementsmentioning

confidence: 99%

Complementary and alternative therapy for pediatric acne: A review of botanical extracts, dietary interventions, and oral supplements

Gurnee

Kamath

Kruse

2019

Pediatric Dermatology

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Many supplements and products containing botanical extracts are marketed to patients for the treatment of acne vulgaris. Additionally, increasing attention has been paid to the role of diet in acne vulgaris. Studies on this topic including pediatric patients are limited, with variable efficacy data. Despite these limitations, knowledge of alternative therapies in pediatric acne vulgaris is often expected from pediatric dermatologists. Here we review available data on the efficacy of complementary and alternative medicines for treatment of acne in pediatric patients, focusing on topical, oral, and dietary modifications.

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“…Plants from the family Berberidaceae are commonly used in traditional Chinese medicine for a variety of ailments, including the chronic skin conditions eczema and psoriasis [15]. This family includes the genus Mahonia and Berberis , which produce flowers and edible berries.…”

Section: Edible Plants and Acnementioning

confidence: 99%

“…Statistical analysis suggested there was no difference between the berberine and minocycline groups. This suggests that herbal supplementation may be just as effective as the standard antibiotics without the drawbacks [15]. …”

Section: Edible Plants and Acnementioning

confidence: 99%

Edible Plants and Their Influence on the Gut Microbiome and Acne

Clark

Haas

Sivamani

2017

IJMS

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Acne vulgaris affects most people at some point in their lives. Due to unclear etiology, likely with multiple factors, targeted and low-risk treatments have yet to be developed. In this review, we explore the multiple causes of acne and how plant-based foods and supplements can control these. The proposed causative factors include insulin resistance, sex hormone imbalances, inflammation and microbial dysbiosis. There is an emerging body of work on the human gut microbiome and how it mediates feedback between the foods we eat and our bodies. The gut microbiome is also an important mediator of inflammation in the gut and systemically. A low-glycemic load diet, one rich in plant fibers and low in processed foods, has been linked to an improvement in acne, possibly through gut changes or attenuation of insulin levels. Though there is much interest in the human microbiome, there is much more unknown, especially along the gut-skin axis. Collectively, the evidence suggests that approaches such as plant-based foods and supplements may be a viable alternative to the current first line standard of care for moderate acne, which typically includes antibiotics. Though patient compliance with major dietary changes is likely much lower than with medications, it is a treatment avenue that warrants further study and development.

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The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review

Cited by 64 publications

References 55 publications

Evaluation of the anti-cancer potential of <i>Mahonia aquifolium</i> extracts via apoptosis and anti-angiogenesis

Evaluation of the anti-cancer potential of <i>Mahonia aquifolium</i> extracts via apoptosis and anti-angiogenesis

Complementary and alternative therapy for pediatric acne: A review of botanical extracts, dietary interventions, and oral supplements

Edible Plants and Their Influence on the Gut Microbiome and Acne

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