2011
DOI: 10.1104/pp.111.188300
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Abstract: The Mediator (Med) complex relays regulatory information from DNA-bound transcription factors to the RNA polymerase II in eukaryotes. This macromolecular unit is composed of three core subcomplexes in addition to a separable kinase module. In this study, conservation of Meds has been investigated in 16 plant species representing seven diverse groups across the plant kingdom. Using Hidden Markov Model-based conserved motif searches, we have identified all the known yeast/metazoan Med components in one or more p… Show more

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Cited by 146 publications
(164 citation statements)
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References 106 publications
(118 reference statements)
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“…The Arabidopsis Mediator complex contains 27 conserved subunits and six additional subunits whose positions in the complex are unassigned (Bäckström et al, 2007;Mathur et al, 2011). A number of Arabidopsis Mediator subunits have been implicated in signaling pathways related to plant development and abiotic responses.…”
mentioning
confidence: 99%
“…The Arabidopsis Mediator complex contains 27 conserved subunits and six additional subunits whose positions in the complex are unassigned (Bäckström et al, 2007;Mathur et al, 2011). A number of Arabidopsis Mediator subunits have been implicated in signaling pathways related to plant development and abiotic responses.…”
mentioning
confidence: 99%
“…The tail submodule is thought to associate directly with transcriptional activators and repressors and the head with Pol II (23). The Arabidopsis mediator complex was purified (28) and, in combination with subsequent bioinformatic analysis (25), 34 subunits were identified, a number of these specific to plants (29). In Arabidopsis, roles for Mediator subunits have been demonstrated in the transcriptional response to a number of biotic (30)(31)(32) and abiotic stress conditions (33,34) as well as in plant development (35,36).…”
mentioning
confidence: 99%
“…Mediator complex was isolated from plants for the first time in 2007 from Arabidopsis cell suspension culture [10]. Since then, genomic analyses allowed identifying genes coding for subunits of Mediator complex in other plant species such as rice [11]. In plants, individual mediator subunits have been implicated in development and stress responses [12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%