The Mechanism of Solar Carcinogenesis

Mackie, Bruce S.

doi:10.1001/archderm.1958.01560080078015

Cited by 69 publications

(9 citation statements)

References 23 publications

(14 reference statements)

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“…Reduced scattering coefficients decrease in all skin lesions compared to their corresponding normal skin, which agrees with previous studies [17,42,43]. One of the main sources of scattering in skin tissue is collagen, so the decrease of reduced scattering coefficients can be explained by a breakdown in the collagen matrix present in the dermis in skin cancer development [44]. For skin cancers, there is also an increase in the thickness of the epidermis with progression of malignancy, so the amount of collagen sampled from in the dermis will decrease and this also results in the lower reduced scattering coefficient [7].…”

Section: Comparison Of Classification Results Between Statistical Asupporting

confidence: 90%

Physiological model using diffuse reflectance spectroscopy for nonmelanoma skin cancer diagnosis

Zhang

Moy

Feng

et al. 2019

Journal of Biophotonics

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Diffuse reflectance spectroscopy (DRS) is a noninvasive, fast, and low‐cost technology with potential to assist cancer diagnosis. The goal of this study was to test the capability of our physiological model, a computational Monte Carlo lookup table inverse model, for nonmelanoma skin cancer diagnosis. We applied this model on a clinical DRS dataset to extract scattering parameters, blood volume fraction, oxygen saturation and vessel radius. We found that the model was able to capture physiological information relevant to skin cancer. We used the extracted parameters to classify (basal cell carcinoma [BCC], squamous cell carcinoma [SCC]) vs actinic keratosis (AK) and (BCC, SCC, AK) vs normal. The area under the receiver operating characteristic curve achieved by the classifiers trained on the parameters extracted using the physiological model is comparable to that of classifiers trained on features extracted via Principal Component Analysis. Our findings suggest that DRS can reveal physiologic characteristics of skin and this physiologic model offers greater flexibility for diagnosing skin cancer than a pure statistical analysis. Physiological parameters extracted from diffuse reflectance spectra data for nonmelanoma skin cancer diagnosis.

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Section: Comparison Of Classification Results Between Statistical Asupporting

confidence: 90%

Physiological model using diffuse reflectance spectroscopy for nonmelanoma skin cancer diagnosis

Zhang

Moy

Feng

et al. 2019

Journal of Biophotonics

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“…XIV and XV) indicate a possible alternative route for fluid transfer in vessels where the basement membrane is lacking. The abnormalities observed in the fine structure of many of the dermal blood-vessels provides support for the hypothesis of Mackie and McGovern (1958) that there is a primary effect on blood-vessels in collagen degeneration, which they suggest could lead to nutritional changes and a subsequent tendency to develop malignant changes.…”

Section: Discussionsupporting

confidence: 54%

“…However these histological changes are never found in the unexposed skin, even in the aged (Hill and Montgomery, 1940;Tattersall and Seville, 1945;Ma and Cowdry, 1950;Marshall, 1965), and so the term senile elastosis should be abandoned. Mackie and McGovern (1958) found that collagen degeneration was present in every case of a large series of solar keratoses, also in every case of squamous cell carcinoma which had developed from a solar keratosis, and in most cases of basal cell carcinoma occurring in exposed parts of the body. They considered that the presence of collagen degeneration affected the nutrition of the overlying epidermis and predisposed to malignant change.…”

mentioning

confidence: 95%

A LIGHT and ELECTRON MICROSCOPICAL STUDY OF COLLAGEN DEGENERATION

Mitchell

1967

Australian and New Zealand Journal of Surgery

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Summary 1. an electron microscopical study of skin with severe collagen degeneration showed that there are changes in elastic, collagen and reticular fibres which lead to a great reduction in the amount of organized fibrous tissue present in the dermis. 2. the collagen fibrils, which are normally formed by tightly packed, strictly aligned filaments, were degraded with the release of the filaments to form disorientated masses. 3. it is suggested that the material which stains like elastin in the dermis is derived from both elastin and collagen. there is hypertrophy and dispersion of elastic fibres, which have degraded collagen added to their surface. there is also a change of narrow bands of the degraded collagen masses to a material looking like elastin. 4. the walls of the small blood‐vessels are profoundly altered, and it is considered that these changes would alter their permeability and therefore affect the nutrition of the overlying epidermis.

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“…From their studies they were able to demonstrate that physiologically significant quantities of UVL traverse the epidermis and they suggested that cutaneous carcinogenesis might not be limited to epidermal events. In this regard, Mackie and McGovern (1958) found squamous cell carcinoma of solar origin in humans always preceded by collagen degeneration and to arise almost always in a preexisting solar keratosis. They concluded that the carcinogenic effect of UVL is mediated by primary action genesis had been suggested earlier by Griffin et al on the dermis.…”

Section: B Skin Opticsmentioning

confidence: 99%