2014
DOI: 10.1016/j.arr.2014.09.005
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Abstract: Slowing the aging process can reduce the risk for multiple chronic diseases simultaneously. It is increasingly recognized that maintaining protein homeostasis (or proteostasis) is important for slowing the aging process. Since proteostasis is a dynamic process, monitoring it is not a simple task and requires use of appropriate methods. This review will introduce methods to assess protein and DNA synthesis using deuterium oxide (D2O), and how protein and DNA synthesis outcomes provide insight into proteostatic … Show more

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Cited by 45 publications
(70 citation statements)
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“…Mitochondrial biogenesis is, therefore, beneficial to sustain high aerobic energy production, but is also reliant on adequate energy availability. In accordance with this idea, we have previously demonstrated in rodent models that during energetic stress, associated with an increase in AMP-activated protein kinase (AMPK) activity or a decrease in the activity of the mechanistic target of rapamycin (mTOR), mitochondrial proteins are often selectively translated (5,10). This selective translation of mitochondrial proteins could be a countermeasure to energetic restriction.…”
mentioning
confidence: 71%
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“…Mitochondrial biogenesis is, therefore, beneficial to sustain high aerobic energy production, but is also reliant on adequate energy availability. In accordance with this idea, we have previously demonstrated in rodent models that during energetic stress, associated with an increase in AMP-activated protein kinase (AMPK) activity or a decrease in the activity of the mechanistic target of rapamycin (mTOR), mitochondrial proteins are often selectively translated (5,10). This selective translation of mitochondrial proteins could be a countermeasure to energetic restriction.…”
mentioning
confidence: 71%
“…However, both studies were performed in June, and because of unusually warm conditions in Alaska, both were performed in ambient temperatures of 27-34°C. Last, labeling for 1 wk may have been an insufficient period of time to have DNA incorporation that was within the limits of detection of the GC-MS, thus limiting our ability to interpret proteostatic mechanisms (4,10). Current studies are in progress to determine mitochondrial function, to determine whether changes occur in the absence of changes in mitochondrial protein synthesis, and to further elucidate mechanisms of physiological remodeling under various environmental stresses.…”
Section: Discussionmentioning
confidence: 99%
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“…Time-dependent decline in protein functions during aging induces a stress over the physiological mechanisms devoted to the clearance of faulty protein molecules, mainly the proteasome and the lysosomes (Miller et al 2014;Taylor et al 2011). Intermediate quality control sensors and effectors, also known as protein chaperones, are also submitted to pressure during aging due to the accumulation of unfolded proteins (Brehme et al 2014;Taylor et al 2011).…”
Section: Molecular Damage As a Driving Factor For Cell Agingmentioning
confidence: 98%