The magnetic resonance imaging evaluation of condylar new bone remodeling after Yang’s TMJ arthroscopic surgery

Dong, Mei; Jiao, Zhipeng; Sun, Qi; Tao, Xiaofeng; Chen, Yang; Qiu, Weimin

doi:10.1038/s41598-021-84591-1

Cited by 18 publications

(12 citation statements)

References 24 publications

(9 reference statements)

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“…[26][27][28] However, the percentage of new bone formation after disk repositioning without ARS was decreased in older patients. 29 The current study confirmed the effect of condylar regeneration and mandibular growth after disk repositioning and ARS in young adults. The SNB angle increased and the ANB angle decreased.…”

Section: Discussionsupporting

confidence: 82%

Comparison of two different therapeutic approaches for skeletal Class II patients with temporomandibular degenerative joint disease

Qin¹,

He²,

Zhang³

et al. 2022

The Angle Orthodontist

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Objectives To compare two different therapeutic approaches for skeletal Class II patients with temporomandibular degenerative joint disease. Materials and Methods A total of 47 patients were included in this study. Group anterior repositioning splint (ARS) was treated with temporomandibular joint (TMJ) disc surgery followed by an ARS and camouflage orthodontic treatment. Group stabilization splint (SS) was treated with an SS followed by orthodontic treatment combined with orthognathic surgery. Cephalometric analysis of lateral radiographs and measurements of condylar height were evaluated before and after splints. Results In group ARS, mandibular advancement was observed after treatment in 21 of 24 patients (87.5%). The SNB angle increased by an average of 1.40 ± 1.01°. The ANB angle, overjet, Wits, and convexity decreased. Facial angle and soft tissue N Vert to pogonion increased. Vertically, MP-FH, MP-SN, y-axis, and vertical ratio decreased and ANS-Me/N-Me and S-Go/N-Me increased, suggesting a counterclockwise rotation of the mandible. In group SS, 18 of 23 patients (78.3%) showed a backward change tendency. The SNB angle reduced by 0.90 ± 0.93°. The ANB angle, overjet, Wits, convexity, and y-axis increased. The facial angle and soft tissue N Vert to soft tissue pogonion (ST N Vert to ST pogonion) decreased. Magnetic resonance imaging showed condylar height increased by 1.45 ± 3.05 mm (P = .002) in group ARS. In group SS, condylar height change was not consistent. Conclusions TMJ disc surgery followed by ARS promoted condylar bone remodeling and regeneration. The SNB angle increased, and the severity of skeletal Class II was improved. The SS enabled the mandible to withdraw backward and revealed a retrognathic but true mandible position.

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Section: Discussionsupporting

confidence: 82%

Comparison of two different therapeutic approaches for skeletal Class II patients with temporomandibular degenerative joint disease

Qin¹,

He²,

Zhang³

et al. 2022

The Angle Orthodontist

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“…MRI scans were acquired by a 1.5-T imager (Signa, General Electric Medical Systems, Milwaukee, WI) with bilateral 3-inch TMJ surface coil receivers for all patients before and after operation and during follow-ups. Oblique sagittal images with closed- (proton density-weighted imaging, PDWI) and open-mouth (T2-weighted images, T2WI) positions and coronal images (T2WI) of the condyle were acquired for evaluation of disc position and condylar bone status [ 19 ]. When the posterior band of the disc was at the 1 to 2 o’clock position of the condyle, it was considered overcorrected and well positioned.…”

Section: Methodsmentioning

confidence: 99%

Disc repositioning by open suturing vs. mini-screw anchor: stability analysis when combined with orthognathic surgery for hypoplastic condyles

Hua

Lü

Zhao

et al. 2022

BMC Musculoskelet Disord

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Background Disc repositioning by Mitek anchors for anterior disc displacement (ADD) combined with orthognathic surgery gained more stable results than when disc repositioning was not performed. But for hypoplastic condyles, the implantation of Mitek anchors may cause condylar resorption. A new disc repositioning technique that sutures the disc to the posterior articular capsule through open incision avoids the implantation of the metal equipment, but the stability when combined with orthognathic surgery is unknown. The purpose of this study was to evaluate the stability of temporomandibular joint (TMJ) disc repositioning by open suturing in patients with hypoplastic condyles when combined with orthographic surgery. Methods Patients with ADD and jaw deformity from 2017 to 2021 were included. Disc repositioning by either open suturing or mini-screw anchor were performed simultaneously with orthognathic surgery. MRI and CT images before and after operation and at least 6 months follow-ups were taken to evaluate and compare the TMJ disc and jaw stability. ProPlan CMF 1.4 software was used to measure the position of the jaw, condyle and its surface bone changes. Results Seventeen patients with 20 hypoplastic condyles were included in the study. Among them, 12 joints had disc repositioning by open suturing and 8 by mini-screw anchor. After an average follow-up of 18.1 months, both the TMJ disc and jaw position were stable in the 2 groups except 2 discs moved anteriorly in each group. The overall condylar bone resorption was 8.3% in the open suturing group and 12.5% in the mini-screw anchor group. Conclusions Disc repositioning by open suturing can achieve both TMJ and jaw stability for hypoplastic condyles when combined with orthognathic surgery.

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“…It presented as a rough and discontinuous cortical bone outline in the sagittal view with decreased condylar height as compared with baseline (Shen et al 2014; Liu et al 2018). At 6 mo after surgery, patients again underwent TMJ-MRI; according to which, new bone formation was defined as the condyle head presenting with a double cortical phenomenon and increased condylar height as compared with baseline (Liu et al 2018; Dong et al 2021)…”

Section: Methodsmentioning

confidence: 99%

“…Once severe resorption appears, complicated surgery is required, including arthroplasty and joint replacement, which might be physically and economically stressful for patients. Meanwhile, early intervention such as disc reposition is reported to promote condylar regeneration in some cases (Liu et al 2018; Dong et al 2021). This postoperative new bone, which is deemed a positive index of the treatment, can improve or even reverse facial deformity (Liu et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Proteome Analysis of Temporomandibular Joint with Disc Displacement

et al. 2022

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Disc displacement without reduction is a common disorder of the temporomandibular joint, causing clinical symptoms and sometimes condylar degeneration. In some cases, bone regeneration is detected following disc-repositioning procedures. Until now, however, systems-wide knowledge of the protein levels for condylar outcome with disc position is still lacking. Here, we performed comprehensive expression profiling of synovial fluid from 109 patients with disc displacement without reduction using high-resolution data-independent acquisition mass spectrometry and characterized differences in 1,714 proteins. Based on magnetic resonance imaging, samples were divided into groups with versus without condylar absorption and subgroups with versus without new bone. For the proteomic analysis, 32 proteins in groups presented with statistical significance (>2-fold, P < 0.05). Pathways such as response to inorganic substances, blood coagulation, and estrogen signaling were significantly expressed in the group with bone absorption as compared with pathways such as regulation of body fluid levels, vesicle-mediated transport, and focal adhesion, which were enriched in the group without bone absorption. In subgroup analysis, 45 proteins of significant importance (>2-fold, P < 0.05) were associated with pathways including would healing, glycolysis and gluconeogenesis, and amino acid metabolism. Combined with clinical examination, molecules such as acetyl-CoA carboxylase beta (ACACB) and transforming growth factor beta 1 (TGFB1) were related to features such as visual analog scale and maximum interincisal opening ( P < 0.05). In addition, 7 proteins were examined by Western blotting, including progesterone immunomodulatory binding factor 1 (PIBF1), histidine-rich glycoprotein (HRG), and protein kinase C and casein kinase substrate in neurons 2 (PACSIN2). In conclusion, this study provides the first proteome analysis of condylar absorption at disc displacement without reduction and postoperative new bone formation after disc reposition. Integrated with clinical data, this analysis provides an important insight into the proteomics of condylar modification at disc position.

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The magnetic resonance imaging evaluation of condylar new bone remodeling after Yang’s TMJ arthroscopic surgery

Cited by 18 publications

References 24 publications

Comparison of two different therapeutic approaches for skeletal Class II patients with temporomandibular degenerative joint disease

Comparison of two different therapeutic approaches for skeletal Class II patients with temporomandibular degenerative joint disease

Disc repositioning by open suturing vs. mini-screw anchor: stability analysis when combined with orthognathic surgery for hypoplastic condyles

Proteome Analysis of Temporomandibular Joint with Disc Displacement

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