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Cited by 60 publications
(45 citation statements)
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“…Apart from this, MYD88 gene, a vital upstream regulator of nuclear factor κB (NF-κB) signaling, was methylated by METTL3, followed by activation of NF-κB and repression of osteogenic progression. Meanwhile, the METTL3-mediated osteogenic differentiation tendency could be reversed by demethylase ALKBH5 ( Yu et al, 2020 ). Moreover, silencing METTL3 decreased the osteogenic markers, Smad signaling, and mineralized nodules in preosteoblast MC3T3-E1 cells, indicating the reduction of osteoblast differentiation ( Zhang Y. et al, 2019 ).…”
Section: Rna M 6 a Methylation In Musculoskeletal mentioning
confidence: 99%
“…Apart from this, MYD88 gene, a vital upstream regulator of nuclear factor κB (NF-κB) signaling, was methylated by METTL3, followed by activation of NF-κB and repression of osteogenic progression. Meanwhile, the METTL3-mediated osteogenic differentiation tendency could be reversed by demethylase ALKBH5 ( Yu et al, 2020 ). Moreover, silencing METTL3 decreased the osteogenic markers, Smad signaling, and mineralized nodules in preosteoblast MC3T3-E1 cells, indicating the reduction of osteoblast differentiation ( Zhang Y. et al, 2019 ).…”
Section: Rna M 6 a Methylation In Musculoskeletal mentioning
confidence: 99%
“…To the Editor, Nucleotide methylation, notably in the forms of 5methylcytosine (5mC) in DNA and N6-methyladenosine (m 6 A) in mRNA, carries important information for gene regulation [1]. Recent research advances highlight the biological importance of m 6 A methylation as a dynamic and reversible post-transcriptional modification [2]. 5mC DNA methylation, a conserved epigenetic modification along with m 6 A RNA modification, also plays critical roles in fundamental biological processes [3,4].…”
mentioning
confidence: 99%
“…However, ZC3H13 depletion impairs self-renewal of mouse embryonic stem cells due to the cells cultured in metastable naive condition [114]. METTL3 depletion potentiates both calcium deposition and alkaline phosphatase activity of mesenchymal stem cells by modulating the expression of MYD required for activating NF-κB, as a repressor of osteogenesis, which uncovers the inhibitory role of METTL3 in osteogenic differentiation [115]. ALKBH5 deteriorates the m 6 A modification of NANOG mRNA to promote its expression in breast cancer stem cells following exposure to hypoxia, which furtherly accelerates cell proliferation and regulates cell differentiation [116].…”
Section: A In Immune Responsementioning
confidence: 92%