The long-term benefits of nucleos(t)ide analogs in compensated HBV cirrhotic patients with no or small esophageal varices: A 12-year prospective cohort study

Lampertico, Pietro; Invernizzi, Federica; Viganò, Mauro; Loglio, Alessandro; Mangia, G.; Facchetti, F.; Primignani, Massimo; Jovani, Manol; Iavarone, M.; Fraquelli, Mirella; Casazza, Giovanni; Franchis, Roberto de; Colombo, Massimo

doi:10.1016/j.jhep.2015.06.006

Cited by 75 publications

(58 citation statements)

References 52 publications

(86 reference statements)

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“…All chronic hepatitis and cirrhosis patients in the present study were considered for anti-HBV treatment and, in accordance with the current national guidelines [13, 37, 38], some were left untreated and some were treated with either peginterferon α-2a or nucleos(t)ide analogues, with results similar to those observed for the local Italian population [39–42]. …”

Section: Discussionmentioning

confidence: 96%

Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy: demographic, virological, and clinical features

Coppola

Alessio

Gualdieri³

et al. 2017

Infect Dis Poverty

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BackgroundThe data on hepatitis b virus (HBV) infection in immigrants population are scanty. The porpoise of this study was to define the demographic, virological, and clinical characteristics of subjects infected with HBV chronic infection in a cohort of immigrants living in Naples, Italy.MethodsA screening for HBV infection was offered to 1,331 immigrants, of whom 1,212 (91%) (831 undocumented immigrants and 381 refugees) accepted and were screened for hepatitis B surface antigen (HBsAg) and anti-hepatitis B core antibody (HBc). Those found to be HBsAg positive were further investigated at third-level infectious disease units.ResultsOf the 1,212 immigrants screened, 116 (9.6%) were HBsAg positive, 490 (40.4%) were HBsAg negative/anti-HBc positive, and 606 (50%) were seronegative for both. Moreover, 21 (1.7%) were anti-human immunodeficiency virus positive and 45 (3.7%) were anti-hepatitis C virus positive. The logistic regression analysis showed that male sex (OR: 1.79; 95%CI: 1.28–2.51), Sub-Saharan African origin (OR: 6.18; 95%CI: 3.37–11.36), low level of schooling (OR: 0.96; 95%CI: 0.94–0.99), and minor parenteral risks for acquiring HBV infection (acupuncture, tattoo, piercing, or tribal practices, OR: 1.54; 95%CI: 1.1–2.16) were independently associated with ongoing or past HBV infection. Of the 116 HBsAg-positive immigrants, 90 (77.6%) completed their diagnostic itinerary at a third-level infectious disease unit: 29 (32.2%) were asymptomatic non-viremic HBsAg carriers, 43 (47.8%) were asymptomatic viremic carriers, 14 (15.6%) had chronic hepatitis, and four (4.4%) had liver cirrhosis, with superimposed hepatocellular carcinoma in two.ConclusionsThe data illustrate the demographic, clinical and virological characteristics of HBV infection in immigrants in Italy and indicate the need for Italian healthcare authorities to enhance their support for providing screening, HBV vaccination, treatment, and educational programs for this populations.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-016-0228-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 96%

Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy: demographic, virological, and clinical features

Coppola

Alessio

Gualdieri³

et al. 2017

Infect Dis Poverty

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“…The additional impact of long-term HBV viral control through the dual activity of nucleos(t)ide analogs would be expected to reduce complications related to chronic HBV infection. HBV suppression has been shown to reduce liver-related outcomes in HBV monoinfection [32,33] and to reduce hepatic decompensation in triply infected patients [34]. However, there are little long-term data on the impact of HBV DNA suppression on liver disease progression in HIV coinfection.…”

Section: Discussionmentioning

confidence: 99%

Risk of End-Stage Liver Disease in HIV-Viral Hepatitis Coinfected Persons in North America From the Early to Modern Antiretroviral Therapy Eras

et al. 2016

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“…It therefore represents the cornerstone endpoint of all our current therapeutic attempts. 1,25,[34][35][36][37][38][39][40] The level of HBV DNA suppression that should be attained in order to achieve these benefits is not well defined, but inferred that the lower, the better. Treatment-induced HBeAg loss and seroconversion to antiHBe characterises the induction of a partial immune control often leading to a low replicative phase of the chronic HBV infection.…”

Section: Recommendationsmentioning

confidence: 99%

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

Lampertico¹,

Agarwal²,

Berg³

et al. 2017

Journal of Hepatology

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3,081

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The long-term benefits of nucleos(t)ide analogs in compensated HBV cirrhotic patients with no or small esophageal varices: A 12-year prospective cohort study

Cited by 75 publications

References 52 publications

Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy: demographic, virological, and clinical features

Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy: demographic, virological, and clinical features

Risk of End-Stage Liver Disease in HIV-Viral Hepatitis Coinfected Persons in North America From the Early to Modern Antiretroviral Therapy Eras

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

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