The long non-coding RNA FLJ46906 binds to the transcription factors NF-κB and AP-1 and regulates expression of aging-associated genes

Yo, Kazuyuki; Rünger, Thomas M.

doi:10.18632/aging.101528

Cited by 15 publications

(8 citation statements)

References 44 publications

(40 reference statements)

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“…Moreover, the lncRNA FLJ46906 may regulate the expression of various aging-associated genes ( e.g. TGFB1 , CXCL8 , IL1B , IL6 , and ELN ) through modulation of the NF-κB and AP-1 transcription factors in human fibroblasts (98). Thus, because of the abundance of lncRNAs in vertebrate genomes, it is likely that many of them may play important roles in adult tissue homeostasis and regulation of the aging process.…”

Section: Remodeling Of the Transcriptional Splicing Landscape With Agmentioning

confidence: 99%

Multi-level remodeling of transcriptional landscapes in aging and longevity

Lai

Danthi

et al. 2019

BMB Rep.

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In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and gene expression has been observed to be deregulated with aging. In this review, we discuss the current knowledge on the transcriptional alterations that have been described to occur with age in metazoans. First, we discuss age-related transcriptional changes in protein-coding genes, the expected functional impact of such changes, and how known pro-longevity interventions impact these changes. Second, we discuss the changes and impact of emerging aspects of transcription in aging, including age-related changes in splicing, lncRNAs and circRNAs. Third, we discuss the changes and potential impact of transcription of transposable elements with aging. Fourth, we highlight small ncRNAs and their potential impact on the regulation of aging phenotypes. Understanding the aging transcriptome will be key to identify important regulatory targets, and ultimately slow-down or reverse aging and extend healthy lifespan in humans.

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Section: Remodeling Of the Transcriptional Splicing Landscape With Agmentioning

confidence: 99%

Multi-level remodeling of transcriptional landscapes in aging and longevity

Lai

Danthi

et al. 2019

BMB Rep.

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“…Dysregulation of lncRNAs has been reported to be associated with several human diseases, including autoimmune diseases and different types of tumors [7,8,21,[36][37][38][39]. Recently, lncRNAs broad expression in cutaneous disorders including systemic lupus erythematosus (SLE), sensitive skin, psoriasis, and aging process has been documented [40][41][42][43]. ese results raise the possibility that lncRNAs play central functional roles in the pathology of inflammatory and immune disorders.…”

Section: Discussionmentioning

confidence: 97%

“…ese results raise the possibility that lncRNAs play central functional roles in the pathology of inflammatory and immune disorders. Moreover, these effects would be mainly mediated by the NF-κB, AP-1, focal adhesion, and PI3K-Akt signaling pathways [41,42]. However, the relationships between the lncRNA-mRNA network and rosacea have not been elucidated so far.…”

Section: Discussionmentioning

confidence: 99%

Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea

Wang

et al. 2020

BioMed Research International

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Rosacea is a chronic and relapsing inflammatory cutaneous disorder with highly variable prevalence worldwide that adversely affects the health of patients and their quality of life. However, the molecular characterization of each rosacea subtype is still unclear. Furthermore, little is known about the role of long noncoding RNAs (lncRNAs) in the pathogenesis or regulatory processes of this disorder. In the current study, we established lncRNA-mRNA coexpression networks for three rosacea subtypes (erythematotelangiectatic, papulopustular, and phymatous) and performed their functional enrichment analyses using Gene Onotology, KEGG, GSEA, and WGCNA. Compared to the control group, 13 differentially expressed lncRNAs and 525 differentially expressed mRNAs were identified in the three rosacea subtypes. The differentially expressed genes identified were enriched in four signaling pathways and the GO terms found were associated with leukocyte migration. In addition, we found nine differentially expressed lncRNAs in all three rosacea subtype-related networks, including NEAT1 and HOTAIR, which may play important roles in the pathology of rosacea. Our study provided novel insights into lncRNA-mRNA coexpression networks to discover the molecular mechanisms involved in rosacea development that can be used as future targets of rosacea diagnosis, prevention, and treatment.

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“…Consequently, future research must continue to examine the molecular networks in its entirety, as novel interacting partners may be discovered using such an approach. After all, ncRNAs [69,70] and other epigenetic mediators, such as p300 (please see Section 4.1.2. ), can control the expressions of various transcription factors [49,54], providing an added layer of complexity to transcriptional regulation.…”

Section: Hyperglycemia and Gene Transcriptionmentioning

confidence: 99%

Increased Extracellular Matrix Protein Production in Chronic Diabetic Complications: Implications of Non-Coding RNAs

Biswas

Chakrabarti

2019

ncRNA

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Management of chronic diabetic complications remains a major medical challenge worldwide. One of the characteristic features of all chronic diabetic complications is augmented production of extracellular matrix (ECM) proteins. Such ECM proteins are deposited in all tissues affected by chronic complications, ultimately causing organ damage and dysfunction. A contributing factor to this pathogenetic process is glucose-induced endothelial damage, which involves phenotypic transformation of endothelial cells (ECs). This phenotypic transition of ECs, from a quiescent state to an activated dysfunctional state, can be mediated through alterations in the synthesis of cellular proteins. In this review, we discussed the roles of non-coding RNAs, specifically microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in such processes. We further outlined other epigenetic mechanisms regulating the biogenesis and/or function of non-coding RNAs. Overall, we believe that better understanding of such molecular processes may lead to the development of novel biomarkers and therapeutic strategies in the future.

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The long non-coding RNA FLJ46906 binds to the transcription factors NF-κB and AP-1 and regulates expression of aging-associated genes

Cited by 15 publications

References 44 publications

Multi-level remodeling of transcriptional landscapes in aging and longevity

Multi-level remodeling of transcriptional landscapes in aging and longevity

Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea

Increased Extracellular Matrix Protein Production in Chronic Diabetic Complications: Implications of Non-Coding RNAs

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