2018
DOI: 10.18632/aging.101528 View full text |Buy / Rent full text
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Abstract: Several features differentiate aged cells from young cells, many of which are due to changes in gene expression during the aging process. The mechanisms of altered gene expression in aging cells remain incompletely understood, and we hypothesized that long non-coding (lnc) RNAs mediate at least some of these changes. We screened for alterations in lncRNA expression with aging in skin fibroblasts and identified the lncRNA FLJ46906 to be consistently upregulated with aging in-vivo and in-vitro. The function of t… Show more

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“…Moreover, the lncRNA FLJ46906 may regulate the expression of various aging-associated genes ( e.g. TGFB1 , CXCL8 , IL1B , IL6 , and ELN ) through modulation of the NF-κB and AP-1 transcription factors in human fibroblasts (98). Thus, because of the abundance of lncRNAs in vertebrate genomes, it is likely that many of them may play important roles in adult tissue homeostasis and regulation of the aging process.…”
Section: Remodeling Of the Transcriptional Splicing Landscape With Agmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Moreover, the lncRNA FLJ46906 may regulate the expression of various aging-associated genes ( e.g. TGFB1 , CXCL8 , IL1B , IL6 , and ELN ) through modulation of the NF-κB and AP-1 transcription factors in human fibroblasts (98). Thus, because of the abundance of lncRNAs in vertebrate genomes, it is likely that many of them may play important roles in adult tissue homeostasis and regulation of the aging process.…”
Section: Remodeling Of the Transcriptional Splicing Landscape With Agmentioning
“…Dysregulation of lncRNAs has been reported to be associated with several human diseases, including autoimmune diseases and different types of tumors [7,8,21,[36][37][38][39]. Recently, lncRNAs broad expression in cutaneous disorders including systemic lupus erythematosus (SLE), sensitive skin, psoriasis, and aging process has been documented [40][41][42][43]. ese results raise the possibility that lncRNAs play central functional roles in the pathology of inflammatory and immune disorders.…”
Section: Discussionmentioning
“…ese results raise the possibility that lncRNAs play central functional roles in the pathology of inflammatory and immune disorders. Moreover, these effects would be mainly mediated by the NF-κB, AP-1, focal adhesion, and PI3K-Akt signaling pathways [41,42]. However, the relationships between the lncRNA-mRNA network and rosacea have not been elucidated so far.…”
Section: Discussionmentioning
“…Consequently, future research must continue to examine the molecular networks in its entirety, as novel interacting partners may be discovered using such an approach. After all, ncRNAs [69,70] and other epigenetic mediators, such as p300 (please see Section 4.1.2. ), can control the expressions of various transcription factors [49,54], providing an added layer of complexity to transcriptional regulation.…”
Section: Hyperglycemia and Gene Transcriptionmentioning