The Linkage Between Coenzyme A Metabolism and Inflammation: Roles of Pantetheinase

Nitto, Takeaki; Onodera, Kenji

doi:10.1254/jphs.13r01cp

Cited by 61 publications

(53 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, although arginase activity has been correlated with the function of MDSCs [15,16], L-arginine supplementation failed to demonstrate a clinical benefit [17]. GPI-80 is suggested to work as a modulator of macrophage-1 antigen (Mac-1) (CD11b/CD18) function [18]. GPI-80 is suggested to work as a modulator of macrophage-1 antigen (Mac-1) (CD11b/CD18) function [18].…”

Section: Introductionmentioning

confidence: 99%

The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood

Takeda

Kato

Ito

et al. 2016

Clinical and Experimental Immunology

View full text Add to dashboard Cite

Myeloid-derived suppressor cells (MDSCs) have a wide spectrum of immunosuppressive activity; control of these cells is a new target for improving clinical outcomes in cancer patients. MDSCs originate from unusual differentiation of neutrophils or monocytes induced by inflammatory cytokines, including granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage (GM)-CSF. However, MDSCs are difficult to detect in neutrophil or monocyte populations because they are not uniform cells, resembling both neutrophils and monocytes; thus, they exist in a heterogeneous population. In this study, we investigated GPI-80, a known regulator of Mac-1 (CD11b/CD18) and associated closely with neutrophil maturation, to clarify this unusual differentiation. First, we demonstrated that the mean fluorescence intensity (MFI) of GPI-80 and coefficient of variation (CV) of GPI-80 were increased by treatment with G-CSF and GM-CSF, respectively, using a human promyelocytic leukaemia (HL60) cell differentiation model. To confirm the value of GPI-80 as a marker of unusual differentiation, we measured GPI-80 expression and MDSC functions using peripheral blood cells from metastatic renal cell carcinoma patients. The GPI-80 CV was augmented significantly in the CD16 neutrophil cell population, and GPI-80 MFI was increased significantly in the CD33 monocyte cell population. Furthermore, the GPI-80 CV in the CD16 population was correlated inversely with the proliferative ability of T cells and the GPI-80 MFI of the CD33 population was correlated with reactive oxygen species production. These results led us to propose that the pattern of GPI-80 expression in these populations is a simple and useful marker for unusual differentiation, which is related to MDSC functions.

show abstract

Section: Introductionmentioning

confidence: 99%

The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood

Takeda

Kato

Ito

et al. 2016

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…XDH plays a major role in phagocytic killing47 and high expression levels are indicative of activated and infected macrophages in M paratuberculosis and is characteristic of oxidative stress. VNN1 is involved in cysteamine production, a major promotor of inflammation48 and polymorphisms of human VNN1 are linked to susceptibility to IBD49. FGF23 is expressed by activated macrophages, and elevated levels impair neutrophil recruitment50.…”

Section: Discussionmentioning

confidence: 99%

Pathways and Genes Associated with Immune Dysfunction in Sheep Paratuberculosis

Gossner¹,

Watkins

Chianini

2017

Sci Rep

View full text Add to dashboard Cite

Multibacillary and paucibacillary paratuberculosis are both caused by Mycobacterium avium subspecies paratuberculosis. Multibacillary lesions are composed largely of infected epithelioid macrophages and paucibacillary lesions contain T cells but few bacteria. Multibacillary disease is similar to human lepromatous leprosy, with variable/high levels of antibody and a dysfunctional immune response. Animals with paucibacillary disease have high cell-mediated immunity and variable levels of antibody. This study aims to characterize the immunological dysfunction using TruSeq analysis of the ileocaecal lymph node that drains disease lesions. Immune dysfunction is highlighted by repression of TCR/CD3 genes, T cell co-receptors/co-stimulators, T cell activation and signal-transduction genes. Inflammation was an acute phase response and chronic inflammation, with little evidence of acute inflammation. The high levels of immunoglobulin and plasma cell transcripts is consistent with the anti-MAP antibody responses in paratuberculosis sheep. Also notable was the overwhelming reduction in mast cell transcripts, potentially affecting DC activation of the immune response. This study also shows that there were no fundamental differences in the gene expression patterns in multibacillary and paucibacillary disease, no shift in T cell genes from Th1 to Th2 pattern but rather an incremental decline into immune dysfunction leading to multibacillary pathology.

show abstract

“…However, the exact mechanism of this effect is not understood. More recently the association between CoA metabolism and inflammation has also been suggested as it has been shown that the pantetheinase enzyme that recycles pantothenic acid and pantetheinase gene (vanin-1) knockout mice has been shown to be involved in the progression of inflammatory reactions [16]. The bioavailability of pantothenic acid has been reported in the range of 40–63% and amounts found in 24-h urine samples have been shown to correlate with this intake [17].…”

Section: Discussionmentioning

confidence: 99%

A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne

Yang

Moclair

Hatcher

et al. 2014

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

IntroductionThe purpose of this study was to determine the safety, tolerability and effectiveness of daily administration of an orally administered pantothenic acid-based dietary supplement in men and women with facial acne lesions.MethodsA randomized, double-blind, placebo-controlled study of adults previously diagnosed with mild to moderate acne vulgaris was performed. Subjects were randomized to the study agent, a pantothenic acid-based dietary supplement, or a placebo for 12 weeks (endpoint). The primary outcome of the study was the difference in total lesion count between the study agent group versus the placebo group from baseline to endpoint. Secondary measurements included differences in mean non-inflammatory and inflammatory lesions, Investigators Global Assessment and Dermatology Life Quality Index (DLQI) scores between the two groups. Investigator assessment of overall improvement and skin photographs were also taken. Safety and tolerability endpoints were the assessment of adverse events and measurement of serum complete blood count and hepatic function.ResultsForty-eight subjects were enrolled and 41 were evaluable. There was a significant mean reduction in total lesion count in the pantothenic acid group versus placebo at week 12 (P = 0.0197). Mean reduction in inflammatory lesions was also significantly reduced and DLQI scores were significantly lower at week 12 in the pantothenic acid group versus placebo. The study agent was safe and well tolerated.ConclusionsThe results from this study indicate that the administration of a pantothenic acid-based dietary supplement in healthy adults with facial acne lesions is safe, well tolerated and reduced total facial lesion count versus placebo after 12 weeks of administration. Secondary analysis shows that the study agent significantly reduced area-specific and inflammatory blemishes. Further randomized, placebo-controlled trials are warranted.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-014-0052-3) contains supplementary material, which is available to authorized users.

show abstract

The Linkage Between Coenzyme A Metabolism and Inflammation: Roles of Pantetheinase

Cited by 61 publications

References 39 publications

The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood

The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood

Pathways and Genes Associated with Immune Dysfunction in Sheep Paratuberculosis

A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne

Contact Info

Product

Resources

About