The link between total antioxidant status, total oxidant status, arylesterase activity, and subgingival microbiota in psoriasis patients

Abstract

Background Studies focusing on the relationship between periodontitis and systemic diseases have suggested a possible association between these two chronic and inflammatory disorders. We aimed to comparatively investigate the salivary oxidative status, biomarker levels, clinical findings, and the microbial load on subgingival biofilm samples in psoriasis patients and controls.Methods Forty participants were allocated into four groups as follows: (1) systemically and periodontally healthy (C group); (2) systemically healthy with periodontitis (P group); ( 3) psoriasis (Ps) and periodontally healthy (Ps-C group); and (4) Ps with periodontitis (Ps-P group). Subgingival biofilm samples were obtained to detect the periodontopathogenic agents by Real-time PCR (qPCR). The total antioxidant status (TAS) (mmol/l), total oxidant status (TOS) (lmol/l), and arylesterase (ARE) activity (U/L) were analyzed using saliva samples. ResultsThe level of TOS and oxidative stress index (OSI) were significantly higher in patients with Ps-P and P compared to controls (P = 0.001, and P ˂ 0.001, respectively). ARE levels were higher in controls compared to Ps and P (P ˂ 0.001). The prevalences of bacteria detected in subgingival biofilm samples were similar between all groups (P > 0.05). ConclusionsThis study reported that psoriasis may amplify TOS and OSI, and the coexistence of psoriasis and periodontitis may aggravate oxidative stress.

Time-restricted eating (16/8) and energy-restricted diet: effects on diet quality, body composition and biochemical parameters in healthy overweight females

“…Oxidative stress index (OSI) was obtained by multiplying the ratio of total oxidant status to total antioxidant status by 100. All units have been converted to µmol/L during the calculation [ 36 ].…”