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Cited by 96 publications
(64 citation statements)
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“…This argument is further strengthened by recent evidence that Th17 cells can provide B-cell help in murine autoantibody-induced arthritis 41 and that B-cell activity in patients with acute viral myocarditis correlated positively with IL-17, but not IFN-γ. 42 Increased levels of IL-17 and Th17 cells have also been reported in the blood of patients with autoimmune thrombocytopenia 43,44 supporting the view that the Th17 subset contributes to pathology in a variety of autoantibody-mediated diseases.…”
Section: Discussionmentioning
confidence: 81%
“…This argument is further strengthened by recent evidence that Th17 cells can provide B-cell help in murine autoantibody-induced arthritis 41 and that B-cell activity in patients with acute viral myocarditis correlated positively with IL-17, but not IFN-γ. 42 Increased levels of IL-17 and Th17 cells have also been reported in the blood of patients with autoimmune thrombocytopenia 43,44 supporting the view that the Th17 subset contributes to pathology in a variety of autoantibody-mediated diseases.…”
Section: Discussionmentioning
confidence: 81%
“…Moreover, IL-23 and T H 17 cells were found to be critical for the induction, but not the effector phase, of EAE, an animal model of human multiple sclerosis (42). In addition, IL-23 and T H 17 cells were found to be linked to the development of multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, chronic immune thrombocytopenia, psoriasis, asthma, atopic dermatitis, and chronic hepatitis B in humans (14)(15)(16)(17)(18)(19)(30)(31)(32). In accordance with these findings, cytokines such as IL-17, IL-17F, IL-22, and IL-6 produced by Th17 cells are found to be elevated in several human inflammatory diseases, and both IL-23 and the Th17 pathway correlate with disease severity and immunopathology in diverse infections (33,34).…”
Section: Discussionmentioning
confidence: 99%
“…The conditions for differentiation of T H 17 cells remain elusive to date, but the levels of IL-12 and IL-23 expression by APCs seems to promote differentiation of naive T cells into T H 17 cells (11)(12)(13). Increases in IL-23-producing CD14 ϩ monocytes or IL-17-producing CD4 ϩ T cells have been found to be associated with immune-mediated diseases (14)(15)(16)(17)(18)(19). Although IL-12 expression has been shown to be significantly suppressed during HCV infection (20)(21)(22)(23), the mechanisms by which HCV mediates the regulation of IL-12 and its relationship to IL-23 expression, whether and how an altered IL-12/IL-23 balance affects T H 17 cell development during HCV infection, remain to be investigated.…”
mentioning
confidence: 99%
“…[15][16][17][18][19][20] A shift toward stimulatory monocytes with enhanced Fc␥R-mediated phagocytic capacity further supports a generalized immune dysregulation in ITP. 21 More recently, studies reported increased Th17 cells or IL-17 cytokine in ITP patients, [22][23][24] implicating a possible role for Th17 cells in ITP immunopathology, although 2 reports did not detect any difference. 25,26 Among the treatment options available to ITP patients, the recently licensed thrombopoietic agents, by increasing platelet production, have yielded overall durable responses in patients with persistent, chronic, and/or refractory ITP while on treatment.…”
Section: Introductionmentioning
confidence: 99%