The Levels of Ghrelin, Leptin, TNF‐<i>α</i>, and IL‐6 in Liver Cirrhosis and Hepatocellular Carcinoma due to HBV and HDV Infection

Ataseven, Hüseyin; Bahçecıoğlu, İbrahim Halil; Kuzu, Nalan; Yalnız, Mehmet; Çelebi, Selman; Erensoy, Ahmet; Üstündağ, Bilal

doi:10.1155/mi/2006/78380

Cited by 89 publications

(95 citation statements)

References 50 publications

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“…HCC commonly arises in the liver with chronic inflammation (10,21). In the liver, the levels of TNF␣, a proinflammatory stimuli, in patients with cirrhosis and HCC have been reported to be significantly higher than those in normal individuals (22). Therefore, the cell growth of phosphorylated HSP27-overexpressed HuH7 cells was examined both in the presence and in the absence of TNF␣.…”

Section: Expression Of Hsp27 Inmentioning

confidence: 99%

Phosphorylated Heat Shock Protein 27 Represses Growth of Hepatocellular Carcinoma via Inhibition of Extracellular Signal-regulated Kinase

Matsushima‐Nishiwaki

Takai

Adachi

et al. 2008

Journal of Biological Chemistry

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Heat shock protein 27, one of the low molecular weight stress proteins, is recognized as a molecular chaperone; however, other functions have not yet been well established. Phosphorylated heat shock protein 27 levels inversely correlate with the progression of human hepatocellular carcinoma. This study shows that phosphorylated heat shock protein 27 interferes with cell growth of the hepatocellular carcinoma-derived HuH7 cells in the presence of the proinflammatory cytokine, tumor necrosis factor-␣, via inhibition of the sustained activation of the extracellular signal-regulated kinase signal pathway. The activities of Raf/extracellular signal-regulated kinase and subsequent activator protein-1 transactivation and the induction levels of cyclin D1 were lower in HuH7 cells transfected with phosphorylated heat shock protein 27 than those with unphosphorylated heat shock protein 27. Moreover, phosphorylated heat shock protein 27 up-regulated the levels of p38 mitogen-activated protein kinase and mitogen-activated protein kinase phosphatase-1, an inhibitory protein of extracellular signal-regulated kinase. These results indicate that phosphorylated heat shock protein 27 might suppress the extracellular signal-regulated kinase activity in the hepatocellular carcinoma cells via two separate pathways in an inflammatory state. The extracellular signal-regulated kinase activity is inversely correlated with phosphorylated heat shock protein 27 at serine 15 and also in human hepatocellular carcinoma tissues in vivo. Because the extracellular signal-regulated kinase signal pathway is a major proliferation signal of hepatocellular carcinoma, activator protein-1 activation is an early event in hepatocarcinogenesis. These findings strongly suggest that the control of the phosphorylated heat shock protein 27 levels could be a new therapeutic strategy especially to counter the recurrence of hepatocellular carcinoma.The mammalian small stress protein, heat shock protein (HSP) 2 27, is a widely expressed 27-kDa protein, and it is one of 10 members of the human low molecular weight HSP family. HSPs are classified into high molecular weight HSPs such as HSP70 and HSP90, and low molecular weight HSPs with molecular masses from 10 to 30 kDa based on their apparent molecular sizes. Low molecular weight HSPs have significant similarities in terms of amino acid sequences, known as the ␣-crystallin domain and WDPF motif (1, 2). The high molecular weight HSPs act as molecular chaperones in protein folding, oligomerization, and translocation (1). Although the functions of low molecular weight HSPs are not as well characterized as those of the high molecular weight HSPs, it is recognized that they may have chaperone activities (1). The functions of HSP27 are regulated by post-translational modifications such as phosphorylation (3, 4). Mouse HSP27 is phosphorylated at two sites (Ser-15 and Ser-82), whereas human HSP27 is phosphorylated at three sites (Ser-15, Ser-78, and Ser-82) (3). Ser-78 and Ser-82 of HSP27 are adjacent to the amino-termin...

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Section: Expression Of Hsp27 Inmentioning

confidence: 99%

Phosphorylated Heat Shock Protein 27 Represses Growth of Hepatocellular Carcinoma via Inhibition of Extracellular Signal-regulated Kinase

Matsushima‐Nishiwaki

Takai

Adachi

et al. 2008

Journal of Biological Chemistry

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“…In fact, most of the leading studies on the correlation between metabolic disturbances and ghrelin have focused on the estimation of total ghrelin (10,11,(13)(14)(15), and there are concerns about the specificity of available acylghrelin assays (17). We focused on measuring total ghrelin, with the aim of comparing our data with the discrepant total ghrelin levels that have been found in hepatic failure patients in different studies (18)(19)(20)(21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Altered fasting and postprandial plasma ghrelin levels in patients with liver failure are normalized after liver transplantation

Diz-Lois

García-Buela²,

Suárez³

et al. 2010

European Journal of Endocrinology

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Context: Anorexia is a problem of paramount importance in patients with advanced liver failure. Ghrelin has important actions on feeding and weight homeostasis. Experimental data exist, which suggest that ghrelin could protect hepatic tissue. Both fasting and post-oral glucose tolerance test (OGTT) ghrelin concentrations are controversial in liver cirrhosis and are unknown after liver transplantation. Objective: Our aim was to study fasting ghrelin concentrations and their response to an OGTT in liver failure patients before and after liver transplantation. Design and methods: We included 21 patients with severe liver failure studied before (pretransplantation, PreT) and 6 months after liver transplantation (posttransplantation, PostT), and 10 age-and body mass index-matched healthy or overweight subjects as the control group (Cont). After an overnight fast, 75 g of oral glucose were administered; glucose, insulin, and ghrelin were obtained at baseline and at times 30, 60, 90, and 120 min.

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“…In contrast to this finding, a study demonstrated that serum ghrelin levels were lower in patients with colorectal carcinoma compared with healthy controls, and patients with end-stage disease had lower ghrelin levels (24). Serum levels of active ghrelin were significantly higher in patients with prostate (18), ovarian (10), and hepatocellular carcinoma (11). Major hyperghrelinemia was observed in end-stage well-differentiated neuroendocrine carcinomas (25).…”

Section: Resultsmentioning

confidence: 93%

“…Circulating ghrelin levels were demonstrated as higher in a range of cancer types including colon cancer (8), prostate carcinoma (9), ovarian carcinoma (10), and hepatocellular carcinoma (11) however, no studies have evaluated serum ghrelin levels in papillary thyroid carcinoma. We aimed to investigate serum levels of ghrelin…”

Section: Introductionmentioning

confidence: 99%

Serum ghrelin levels in papillary thyroid carcinoma

Uçan

Şahi̇n

Kızılgül

et al. 2017

Arch. Endocrinol. Metab.

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Objective: Ghrelin plays a role in several processes of cancer progression, and numerous cancer types express ghrelin and its receptor. We aimed to investigate serum levels of ghrelin in patients with papillary thyroid carcinoma (PTC) and its association with the prognostic factors in PTC. Materials and methods: We enrolled 54 patients with thyroid cancer (7 male, 47 female) and 24 healthy controls (6 male, 18 female) in the study. We compared demographic, anthropometric, and biochemical data, and serum ghrelin levels between the groups. Serum ghrelin levels were measured using as enzyme-linked immunosorbent assay. Results: Ghrelin levels were similar between the groups, but plasma ghrelin levels were significantly higher in tumors larger than 1 cm diameter compared with papillary microcarcinomas. Serum ghrelin levels also correlated with tumor size (r = 0.499; p < 0.001). Body mass index, thyroid-stimulating hormone, and HOMA-IR levels were similar between the groups. There were no statistically significant differences regarding average age and other prognostic parameters including lymph node invasion, capsule invasion, multifocality and surgical border invasion between patients with microcarcinoma and tumors larger than 1 cm. Conclusion: In our study, no significant difference in serum ghrelin levels was determined between patients with papillary thyroid cancer and healthy controls however, serum ghrelin levels were higher in tumors larger than 1 cm compared to in those with thyroid papillary microcarcinoma. Arch Endocrinol Metab. 2017;61(5):464-9

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The Levels of Ghrelin, Leptin, TNF‐α, and IL‐6 in Liver Cirrhosis and Hepatocellular Carcinoma due to HBV and HDV Infection

Cited by 89 publications

References 50 publications

Phosphorylated Heat Shock Protein 27 Represses Growth of Hepatocellular Carcinoma via Inhibition of Extracellular Signal-regulated Kinase

Phosphorylated Heat Shock Protein 27 Represses Growth of Hepatocellular Carcinoma via Inhibition of Extracellular Signal-regulated Kinase

Altered fasting and postprandial plasma ghrelin levels in patients with liver failure are normalized after liver transplantation

Serum ghrelin levels in papillary thyroid carcinoma

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