The level of TSH appeared favourable in maintaining bone mineral density in postmenopausal women

Baqi, L; Payer, Juraj; Killinger, Zdenko; Susienkova, K; Jackuliak, Peter; Čierný, Daniel; Langer, Peter

doi:10.4149/endo_2010_01_9

Cited by 29 publications

(20 citation statements)

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“…We also observed a significant negative correlation between the serum TSH values and the urinary calcium levels and the spot UCa/Cr excretion ratios, which was in compliance with the previous reports [9].…”

Section: Discussionsupporting

confidence: 79%

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Role of TSH on Urinary Calcium Excretion In Post Menopausal Women of South Indian Population

Niranjan¹,

Amrutha²,

Srinivasan³

et al. 2013

JCDR

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Background: Unforeseen aberrations in the hormonal status during the early postmenopausal period are responsible for several complications including osteoporosis. Thyroid Stimulating Hormone (TSH) receptors are isolated from various tissues including the bone. A low serum TSH level is known to stimulate osteoclastic activity in bone and accelerate bone resorption. Urinary calcium/creatinine (UCa/Cr) excretion ratio could be an indirect and an early indicator of loss of Bone Mineral Density (BMD). With this background, this study was planned to explore the association of serum TSH levels with the UCa/Cr excretion ratio.Methods: Forty eight women in the postmenopausal age group, with their menopausal age not more than seven years of duration were included in this study. Based on their TSH values, these subjects were divided into two groups A (TSH<0.5 mIU/L) and B (TSH>0.5mIU/L). Urinary calcium, UCa/Cr excretion ratio, serum phosphorous, calcium and calcium phosphorous multiplication products were estimated and compared between the two groups.Results: Twenty two (46%) women were biochemically asymptomatic hyperthyroid cases and Twenty six (54%) were euthyroid. This study documents high UCa/Cr in Group A compared to that of Group B (p<0.05). We also observed significant negative correlation of TSH with UCa/Cr excretion ratio (p=0.041, r = -0.43). Conclusion:Low serum TSH levels were associated with increased UCa/Cr excretion ratio in postmenopausal women of South Indian population.NiraNjaN G, amrutha P V, SriNiVaSaN a r, rameSh r, SathiShbabu m, Sathiya r

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Section: Discussionsupporting

confidence: 79%

“…A normal or high normal TSH level is known to preserve the BMD [9]. Hormone replacement therapy and calcium supplementation are presently available as the therapeutic modalities for the postmenopausal complications [10].…”

Section: Introductionmentioning

confidence: 99%

Role of TSH on Urinary Calcium Excretion In Post Menopausal Women of South Indian Population

Niranjan¹,

Amrutha²,

Srinivasan³

et al. 2013

JCDR

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“…There is also a strong negative correlation between low serum TSH and high C-telopeptide levels, without an association with thyroid hormone [79]. In patients on L-thyroxine, greater bone loss has been noted in those with a suppressed TSH than those without suppression [57,80,81]. The Tromso study supports this: participants with serum TSH below 2 SD had a significantly lower BMD, those with TSH above 2 SD had a significantly increased BMD, whereas there was no association between TSH and BMD at normal TSH levels [44].…”

Section: Clinical Studiesmentioning

confidence: 99%

Pituitary-bone connection in skeletal regulation

Zaidi

Sun

Liu

et al. 2016

Hormone Molecular Biology and Clinical Investigation

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Pituitary hormones have traditionally been thought to exert specific, but limited function on target tissues. More recently, the discovery of these hormones and their receptors in organs such as the skeleton suggests that pituitary hormones have more ubiquitous functions. Here, we discuss the interaction of growth hormone (GH), follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), prolactin, oxytocin and arginine vasopressin (AVP) with bone. The direct skeletal action of pituitary hormones therefore provides new insights and therapeutic opportunities for metabolic bone diseases, prominently osteoporosis.

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“…A higher BMD has been reported in postmenopausal women with TSH within the physiological range comparing to these with the low level of TSH (Baqi et al, 2010). Clinical observations show that patients with subclinical hyperthyroidism and normal circulating thyroid hormone levels display osteoporotic changes (De Menis et al, 1992; Kisakol et al, 2003).…”

Section: Tsh As a Metabolic Regulatormentioning

confidence: 99%