The level of oxidative stress and the expression of genes involved in DNA-damage signaling pathways in depressive patients with colorectal carcinoma

Wei, Yongchang; Zhou, Fuling; He, Dalin; Bai, Jirong; Hui, Lingyun; Wang, Xin-Yang; Kang, Nan

doi:10.1016/j.jpsychores.2008.09.001

Cited by 45 publications

(34 citation statements)

References 42 publications

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“…The results suggest an association of all the three genes with increased risk of SCCHN. Similarly, Wei et al [50] reported 1.6-2.5-fold reduced expression of these DNA repair genes in the tissue of colorectal patients. Habib [51] reported a decrease in OGG1 protein and mRNA expression in renal tumor samples with a fourfold increase in 8-OHdG levels, in comparison to normal kidney samples.…”

Section: Discussionmentioning

confidence: 86%

Reduced expression of DNA repair genes (XRCC1, XPD, and OGG1) in squamous cell carcinoma of head and neck in North India

et al. 2011

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Squamous cell carcinoma of head and neck (SCCHN) is the sixth most common cancer globally, and in India, it accounts for 30% of all cancer cases. Epidemiological studies have shown a positive association between defective DNA repair capacity and SCCHN. The underlying mechanism of their involvement is not well understood. In the present study, we have analyzed the relationship between SCCHN and the expression of DNA repair genes namely X-ray repair cross-complementing group 1 (XRCC1), xeroderma pigmentosum group D (XPD), and 8-oxoguanine DNA glycosylase (OGG1) in 75 SCCHN cases and equal number of matched healthy controls. Additionally, levels of DNA adduct [8-hydroxyguanine (8-OHdG)] in 45 SCCHN cases and 45 healthy controls were also determined, to ascertain a link between mRNA expression of these three genes and DNA adducts. The relative expression of XRCC1, XPD, and OGG1 in head and neck cancer patients was found to be significantly low as compared to controls. The percent difference of mean relative expression between cases and controls demonstrated maximum lowering in OGG1 (47.3%) > XPD (30.7%) > XRCC1 (25.2%). A negative Spearmen correlation between XRCC1 vs. 8-OHdG in cases was observed. In multivariate logistic regression analysis (adjusting for age, gender, smoking status, and alcohol use), low expression of XRCC1, XPD, and OGG1 was associated with a statistically significant increased risk of SCCHN [crude odds ratios (ORs) (95%CI) OR 2.10; (1.06-4.17), OR 2.76; (1.39-5.49), and 5.24 (2.38-11.52), respectively]. In conclusion, our study demonstrated that reduced expression of XRCC1, XPD, and OGG1 is associated with more than twofold increased risk in SCCHN.

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Section: Discussionmentioning

confidence: 86%

Reduced expression of DNA repair genes (XRCC1, XPD, and OGG1) in squamous cell carcinoma of head and neck in North India

et al. 2011

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“…Depression is also associated with increased levels of lipid peroxidation, comprising elevations in malondialdehyde (Ozcan et al, 2004, Sarandol et al, 2007, Wei et al, 2009, and increased oxidative damage to DNA, characterised by increased levels of 8-hydroxy-2-deoxyguanosine (Forlenza andMiller, 2006, Maes et al, 2009a). Depression is also associated with increased plasma levels of peroxides and xanthine oxidase (Herken et al, 2007, Maes et al, 2010.…”

Section: Oxidative and Nitrosative Stressmentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

506

412

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Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression, namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help to expand our understanding and treatment of major depressive disorder. Mental health interventions, taking into account the bidirectional relationship between these lifestyle factors and major depression are also likely to enhance the efficacy of interventions associated with this disorder.

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“…A body of clinical evidence indicates that depression is characterized by a higher oxidant status. In fact, total oxidant status (TOS) and oxidative stress index (OSI) were increased in depressed patients as compared to normal controls in plasma [3,4] and serum [5,6]. Some studies demonstrated higher levels of plasma peroxides [7] and serum nitric oxide (NO) [5,6,[8][9][10] in depressed patients, while Ozcan and co-workers reported lowered levels of NO in depressed patients in the pre-treatment period [11].…”

Section: Psychiatric Disordersmentioning

confidence: 99%

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga

Niedzielska

Gawlik

et al. 2015

Pharmacological Reports

221

123

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The pathophysiology of psychiatric diseases, including depression, anxiety, schizophrenia and autism, is far from being fully elucidated. In recent years, a potential role of the oxidative stress has been highlighted in the pathogenesis of neuropsychiatric disorders. A body of clinical and preclinical evidence indicates that psychiatric diseases are characterized by higher levels of oxidative biomarkers and with lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review current knowledge on the role of the oxidative stress in psychiatric diseases, based on clinical trials and animal studies, in addition, we analyze the effects of drug-induced modulation of oxidative balance and explore pharmacotherapeutic strategies for oxidative stress reduction.

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The level of oxidative stress and the expression of genes involved in DNA-damage signaling pathways in depressive patients with colorectal carcinoma

Cited by 45 publications

References 42 publications

Reduced expression of DNA repair genes (XRCC1, XPD, and OGG1) in squamous cell carcinoma of head and neck in North India

Reduced expression of DNA repair genes (XRCC1, XPD, and OGG1) in squamous cell carcinoma of head and neck in North India

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

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