The level of liver and renal function biomarker abnormalities among hospitalized COVID-19 patients in Ethiopia

Tsegay, Yakob Gebregziabher; Bitew, Molalegne; Atlaw, Asegidew; Aragaw, Mintesnot; Workneh, Tigist; Gemechu, Messay; Berhane, Nega

doi:10.1101/2022.02.15.22271010

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…Meanwhile, the level of urea, ALP, AST, and creatinine are some of the biomarkers for renal functionality [18]. Decreased levels of urea, globulin, and creatinine in serum correlates with severe malnutrition or liver diseases [19], while significantly low levels of serum ALP and AST observed, as in subacute phase, contraindicate the possibility of developing malnutrition or liver disease.…”

Section: Discussionmentioning

confidence: 99%

E. tapos Yoghurt—A View from Nutritional Composition and Toxicological Evaluation

Naomi

Rusli

Balan

et al. 2022

Foods

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Elateriospermum tapos (E. tapos) is a natural tropical plant that possess a wide range of health benefits. Recent discovery proves that E. tapos extract is able to reduce weight, increase cognitive performance, and ameliorate anxiety and stress hormone. However, this extraction has not been incorporated into yoghurt, and no toxicity studies have been done previously to prove its safety. Thus, this study was aimed to formulate the ethanolic extracted E. tapos into yoghurt and access the toxicological effects on rodents. Forty female Sprague Dawley (SD) rats were used in this study and force fed with either one of the following doses of 250, 500, 1000, or 2000 mg/kg, while the control group received normal saline. The nutritional analysis result showed that the newly formulated yoghurt comprised 328 kJ of energy per 100 mL of servings, 3.6 g of fats, 8.2 g of carbohydrates, 2.7 g of total protein, and 1.2 g of fibre. The peak intensity of Lactobacillus species was observed at 1.6 × 105 CFU/g with a titratable acidity as lactic acid of 0.432 CFU/g, indicating the ability of the formulated yoghurt in stimulating the growth of Lactobacilli. In the experimental study, the E. tapos yoghurt in a single dose (2000 mg/kg) did not show any treatment related to toxicity in any of the rats observed in an additional 14 days. There were no changes in body weight, food and water intake, plasma biochemistry (ALT, AST, ALP, and creatinine), haematological products, and organ weights of the treated groups compared to the subacute control groups. Histological examination of all organs including liver, heart, and kidney were comparable to the control groups. In toto, oral consumptions of E. tapos yoghurt did not induce any adverse effects on rodents.

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Section: Discussionmentioning

confidence: 99%

E. tapos Yoghurt—A View from Nutritional Composition and Toxicological Evaluation

Naomi

Rusli

Balan

et al. 2022

Foods

View full text Add to dashboard Cite

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Correlation between Biomarkers and Severity of Clinical Categories in COVID-19 Patients: A Hospital-Based Study in Arunachal Pradesh, India

Nobin,

Paley,

Anu

et al. 2024

COVID

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Background: The COVID-19 pandemic has brought about widespread effects on communities on a global scale, with impacts varying among different demographics. This study focuses on a unique cohort of COVID-19-positive patients from Arunachal Pradesh, a region in northeast India with a substantial indigenous population. This study aims to delve into the features and consequences of COVID-19 in this indigenous population within this distinct demographic region, with a special focus on assessing the effects on tribal communities. Out of a total of 1627 COVID-19 positive cases, 1392 belonged to various tribes of Arunachal Pradesh, categorized as the indigenous population of the region. Our research primarily focuses on examining the biochemical and inflammatory indicators that forecast the clinical results of COVID-19 patients, specifically within both indigenous and non-indigenous groups. Methods: Biochemical markers, including hematological parameters, liver and kidney function biomarkers, D-DIMER, and inflammatory markers, were assessed along with immune-inflammatory ratios: neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR). Differences in biomarker levels and ratios across disease severities were analyzed, and significant data were observed using descriptive statistics. Results: Elevated levels of Ferritin (CRP, IL-6, D-DIMER, Creatinine, Urea, AST/SGOT, and ALT/SGPT) were associated with increasing disease severity in COVID-19 cases, reflecting increased inflammation, multi-organ dysfunction, and coagulopathy in the severe COVID-19 category amongst the indigenous population. The data showed an aligned report with the non-indigenous population of India when compared with various other studies (using a Spearman rank correlation test). Similarly, an increase in the neutrophil-to-lymphocyte ratio (NLR) and a declining shift in the lymphocyte-to-monocyte ratio (LMR) indicated deregulated immune responses and systemic inflammation in the severe category of COVID-19. Conclusion: This population-based study from northeast India offers important perspectives into the pathophysiology of COVID-19 and its link with disease severity among indigenous and non-indigenous populations.

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The level of liver and renal function biomarker abnormalities among hospitalized COVID-19 patients in Ethiopia

Cited by 2 publications

References 57 publications

E. tapos Yoghurt—A View from Nutritional Composition and Toxicological Evaluation

E. tapos Yoghurt—A View from Nutritional Composition and Toxicological Evaluation

Correlation between Biomarkers and Severity of Clinical Categories in COVID-19 Patients: A Hospital-Based Study in Arunachal Pradesh, India

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