“…Collectively, we found that there is an abundance of guidelines/recommendations, but the question is how many are based on sound, new RCT, or large observational cohort studies. In 2018 the SIG of Pediatrics reported that only a limited number of large RCT's could be identified which might have an impact on the development of clinical guidelines (1). Many of the reports are based on studies of low quality or consensus statements of scientific working groups of international societies such as ESPGHAN, ESPNIC and ASPEN.…”