The Landscape of Circular RNAs in Cardiovascular Diseases

Long, Qi; Lv, Bingjie; Jiang, Shijiu; Lin, Jianwen

doi:10.3390/ijms24054571

Cited by 14 publications

(14 citation statements)

References 132 publications

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“…The unique attribute of circRNAs is a continuous closed-loop structure, allowing for circulatory stability with resistance to nucleases that degrade linear RNAs [ 97 , 98 ]. CircRNAs function as sponges to miRNAs, bind proteins directly, and like lncRNAs, can encode their own proteins [ 99 ]. CircRNAs can contain 200–2000 base pairs, giving each a massive array of potential regulatory functions with many potential targets and binding sites [ 100 , 101 ].…”

Section: Circular Rnas In Cardiac Disease and Fibrosismentioning

confidence: 99%

Non-Coding Ribonucleic Acids as Diagnostic and Therapeutic Targets in Cardiac Fibrosis

Olson,

Tang,

Liu

2024

Curr Heart Fail Rep

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Purpose of Review Cardiac fibrosis is a crucial juncture following cardiac injury and a precursor for many clinical heart disease manifestations. Epigenetic modulators, particularly non-coding RNAs (ncRNAs), are gaining prominence as diagnostic and therapeutic tools. Recent Findings miRNAs are short linear RNA molecules involved in post-transcriptional regulation; lncRNAs and circRNAs are RNA sequences greater than 200 nucleotides that also play roles in regulating gene expression through a variety of mechanisms including miRNA sponging, direct interaction with mRNA, providing protein scaffolding, and encoding their own products. NcRNAs have the capacity to regulate one another and form sophisticated regulatory networks. The individual roles and disease relevance of miRNAs, lncRNAs, and circRNAs to cardiac fibrosis have been increasingly well described, though the complexity of their interrelationships, regulatory dynamics, and context-specific roles needs further elucidation. Summary This review provides an overview of select ncRNAs relevant in cardiac fibrosis as a surrogate for many cardiac disease states with a focus on crosstalk and regulatory networks, variable actions among different disease states, and the clinical implications thereof. Further, the clinical feasibility of diagnostic and therapeutic applications as well as the strategies underway to advance ncRNA theranostics is explored.

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Section: Circular Rnas In Cardiac Disease and Fibrosismentioning

confidence: 99%

Non-Coding Ribonucleic Acids as Diagnostic and Therapeutic Targets in Cardiac Fibrosis

Olson,

Tang,

Liu

2024

Curr Heart Fail Rep

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“…A recent study highlighted the significant role of circRNAs in the development and progression of AF, identifying specific circRNAs that are differentially expressed in both the left and right atrial appendages of AF patients ( Table 7 ). The research suggested that circRNAs, particularly hsa_circ_0003965, may be involved in AF through a unique regulatory mechanism potentially associated with the glucagon signaling pathway [ 80 ].…”

Section: Arrhythmiamentioning

confidence: 99%

The Role of Circular RNA for Early Diagnosis and Improved Management of Patients with Cardiovascular Diseases

Goina,

Farcas

et al. 2024

IJMS

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Cardiovascular diseases (CVDs) are responsible for approximately 17.9 million deaths every year. There is growing evidence that circular RNAs (circRNAs) may play a significant role in the early diagnosis and treatment of cardiovascular diseases. As regulatory molecules, circular RNAs regulate gene expression, interact with proteins and miRNAs, and are translated into proteins that play a key role in a wide variety of biological processes, including the division and proliferation of cells, as well as the growth and development of individuals. An overview of the properties, expression profiles, classification, and functions of circRNAs is presented here, along with an explanation of their implications in cardiovascular diseases including heart failure, hypertension, ischemia/reperfusion injury, myocardial infarction, cardiomyopathies, atherosclerosis, and arrhythmia.

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“…These substances have the potential to modify the regular operation of the cardiac system and play a role in the advancement of cardiomyopathies. Hence, gaining a comprehensive understanding of the involvement of ncRNAs in cardiomyopathies has the potential to offer novel perspectives on the molecular mechanisms that underlie these pathological conditions, and consequently, facilitate the exploration of innovative therapeutic approaches 102 …”

Section: Noncoding Rnas In Cardiomyopathiesmentioning

confidence: 99%

“…Hence, gaining a comprehensive understanding of the involvement of ncRNAs in cardiomyopathies has the potential to offer novel perspectives on the molecular mechanisms that underlie these pathological conditions, and consequently, facilitate the exploration of innovative therapeutic approaches. 102…”

Section: Dysregulation Of Noncoding Rnas In Cardiomyopathiesmentioning

confidence: 99%

Crosstalk of NLRP3 inflammasome and noncoding RNAs in cardiomyopathies

Jafari,

Shahabi Rabori,

Zolfi Gol

et al. 2023

Cell Biochemistry & Function

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Cardiovascular diseases (CVDs) identified as a serious public health problem. Although there is a lot of evidence that inflammatory processes play a significant role in the progression of CVDs, however, the precise mechanism is not fully understood. Nevertheless, recent studies have focused on inflammation and its related agents. Nucleotide oligomerization domain‐, leucine‐rich repeat‐, and pyrin domain‐containing protein 3 (NLRP3) is a type of pattern recognition receptor (PRR) that can recognize pathogen‐associated molecular patterns and trigger innate immune response. NLRP3 is a component of the NOD‐like receptor (NLR) family and have a pivotal role in detecting damage to cardiovascular tissue. It is suggested that activation of NLRP3 inflammasome leads to initiating and propagating the inflammatory response in cardiomyopathy. So, late investigations have highlighted the NLRP3 inflammasome activation in various forms of cardiomyopathy. On the other side, it was shown that noncoding RNAs (ncRNAs), particularly, microRNAs, lncRNAs, and circRNAs possess a regulatory function in the immune system's inflammatory response, implicating their involvement in various inflammatory disorders. In addition, their role in different cardiomyopathies was indicated in recent studies. This review article provides a summary of recent advancements focusing on the function of the NLRP3 inflammasome in common CVDs, especially cardiomyopathy, while also discussing the therapeutic potential of inhibiting the NLRP3 inflammasome regulated by ncRNAs.

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The Landscape of Circular RNAs in Cardiovascular Diseases

Cited by 14 publications

References 132 publications

Non-Coding Ribonucleic Acids as Diagnostic and Therapeutic Targets in Cardiac Fibrosis

Non-Coding Ribonucleic Acids as Diagnostic and Therapeutic Targets in Cardiac Fibrosis

The Role of Circular RNA for Early Diagnosis and Improved Management of Patients with Cardiovascular Diseases

Crosstalk of NLRP3 inflammasome and noncoding RNAs in cardiomyopathies

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