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Cited by 145 publications
(105 citation statements)
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References 134 publications
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“…After correcting for the covariates age, sex, smoking, BMI and medication, we report a reduction of KYN specifically in patients with MDD. This reduction specifically in patients with MDD compared to HC is in line with recent meta-analyses 21 , 22 . We additionally found a reduction of KYNA in patients with MDD.…”
Section: Discussionsupporting
confidence: 89%
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“…After correcting for the covariates age, sex, smoking, BMI and medication, we report a reduction of KYN specifically in patients with MDD. This reduction specifically in patients with MDD compared to HC is in line with recent meta-analyses 21 , 22 . We additionally found a reduction of KYNA in patients with MDD.…”
Section: Discussionsupporting
confidence: 89%
“…The biological effects of 3-OHK are complex and studies have shown both antioxidant effects potentially resulting in neuroprotection and induction of reactive oxygen species leading to neurotoxicity 52 . In addition, 3-OHK is one of the TRYCATs that is examined least frequently: a recent meta-analysis showed that out of 59 studies comparing patients with MDD vs. HC only 6 studies included 3-OHK 22 . Therefore, further studies are needed to elucidate the role of 3-OHK in the pathogenesis of MDD and SZ.…”
Section: Discussionmentioning
confidence: 99%
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“…Behavioural patterns in clinical OCD and SUD were replicated using analogous methods in healthy volunteers high in OC symptoms and trait impulsivity, respectively. Applying reinforcement learning models to PRL may hold promise for refining psychiatric classification (Cuthbert and Insel 2013) and identifying vulnerability factors to an array of psychopathologies (Marx et al 2020), including disorders of compulsivity. Immediate perseveration, by contrast, refers to perseverative errors contiguous with the reversal (Murphy et al 2002); however, the first trial in the reversal phase (trial 41 of 80)…”
Section: Discussionmentioning
confidence: 99%
“…Our study further supports the involvement of the KYN pathway. As was shown in one recent meta-analysis [ 32 ], two KYN-related patterns are present in depression: (1) a shift of tryptophan metabolism from serotonin to the KYN pathway and (2) a preferential metabolism of KYN to neurotoxic quinolinic acid (QUIN). These results supported tryptophan depletion and neurotoxicity as the pathogenic mechanisms of depression.…”
Section: Discussionmentioning
confidence: 99%