The involvement of prolactin in the regulation of adrenal cortex function in pigs

Kamińska, Barbara; Opałka, Marek; Ciereszko, Renata E.; Dusza, Luiza

doi:10.1016/s0739-7240(00)00076-x

Cited by 17 publications

(14 citation statements)

References 42 publications

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“…RIA procedure for T estimation in gander plasma was previously validated [31]. The method for T measurement in gander tissue was based on Kaminska et al [18]. Briefly, steroids from plasma and homogenate containing 100 mg of testicular tissue were extracted using ethyl ether.…”

Section: Steroid Hormone Assaymentioning

confidence: 99%

Seasonal changes in the expression of the androgen receptor in the testes of the domestic goose (Anser anser f. domestica)

Leska

Kieżun

Kamińska

et al. 2012

General and Comparative Endocrinology

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Section: Steroid Hormone Assaymentioning

confidence: 99%

Seasonal changes in the expression of the androgen receptor in the testes of the domestic goose (Anser anser f. domestica)

Leska

Kieżun

Kamińska

et al. 2012

General and Comparative Endocrinology

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“…In pigs, PRL exerts its most significant effects on mammary gland growth (Farmer et al 2000), lactation (Farmer et al 1998) and reproduction (Young et al 1990, Ciereszko et al 2002, while it also modulates biological responses including stress (Kaminska et al 2000) and maternal behavior (Farmer et al 1998(Farmer et al , 1999. The role for PRL during mammary gland growth and lactation in swine is crucial, where inadequate milk production can impair the pre-and post-weaning growth of nursing pigs (Hurley 2001).…”

Section: Introductionmentioning

confidence: 99%

Tissue-specific regulation of porcine prolactin receptor expression by estrogen, progesterone, and prolactin

Trott

Horigan

Gloviczki

et al. 2009

Journal of Endocrinology

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Prolactin (PRL) acts through its receptor (PRLR) via both endocrine and local paracrine/autocrine pathways to regulate biological processes including reproduction and lactation. We analyzed the tissue-and stage of gestationspecific regulation of PRL and PRLR expression in various tissues of pigs. Abundance of pPRLR-long form (LF) mRNA increased in the mammary gland and endometrium during gestation while in other tissues it remained constant. There was a parallel increase in the abundance of the pPRLR-LF protein in the mammary gland and endometrium during gestation. We determined the hormonal regulation of pPRLR-LF mRNA expression in various tissues from ovariectomized, hypoprolactinemic gilts given combinations of the replacement hormones estrogen (E 2 ), progestin (P), and/or haloperidol-induced PRL. Abundance of pPRLR-LF mRNA in kidney and liver was unaffected by hormone treatments. Expression of uterine pPRLR-LF mRNA was induced by E 2 whereas the effect of E 2 was abolished by co-administering P. The expression of pPRLR-LF mRNA in the mammary gland stroma was induced by PRL, whereas E 2 induced its expression in the epithelium. In contrast to these changes in pPRLR expression, pPRL expression was relatively constant and low during gestation in all tissues except the pituitary. Taken together, these data reveal that specific combinations of E 2 , P, and PRL differentially regulate pPRLR-LF expression in the endometrium and mammary glands, and that the action of PRL on its target tissues is dependent upon pPRLR-LF abundance more so than the local PRL expression.

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“…The specificity of antibodies against cortisol and androstenedione has been previously reported (Kaminska et al, 2000;Szafranska et al, 2002, respectively). The sensitivities of both assays are 15 and 2 pg/tube for cortisol and androstenedione, respectively.…”

Section: Hormone Assaysmentioning

confidence: 52%

Phytoestrogens alter cortisol and and rostenedione secretion by porcine adrenocortical cells

Kamińska

Opałka

Dusza

2007

Acta Veterinaria Hungarica

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The effect of plant-derived, nonsteroidal estrogens (genistein, daidzein and biochanin A) on cortisol and androstenedione secretion by porcine adrenocortical cells was examined. Adrenals were harvested from locally slaughtered mature gilts on days 5-9 of the oestrous cycle. Adrenocortical cells were incubated with or without genistein, daidzein, biochanin A (0.5, 5, 10 or 50 µM), oestradiol (10, 50, 100 or 500 pg/mL) and ACTH (5 nM -positive control). All incubations were performed for 8 h (95% air and 5% CO 2 , 37 °C). ACTH increased cortisol and androstenedione secretion. Genistein, daidzein and biochanin A suppressed cortisol output, whereas androstenedione secretion was enhanced by these phytoestrogens. In contrast, oestradiol did not alter steroid secretion by porcine adrenocortical cells, which may suggest that phytoestrogens have a non-oestrogenic mechanism of action. Therefore, phytoestrogens present in commercial forage may influence adrenocortical function in pigs by decreasing cortisol and increasing androstenedione secretion. Key words: Phytoestrogens, isoflavones, adrenocortical cells, pigPhytoestrogens are phytochemicals present in whole plants, their seeds and plant-derived preserves (Reinli and Block, 1996). These compounds are widely present in legumes and beans, which are the main components of the fodder of farm animals and constitute an integral part of the human diet (Lundh, 1995;Duncan et al., 2003). Soybeans, commonly used in pig diets, are the most significant source of isoflavones (one of the phytoestrogen classes) including

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The involvement of prolactin in the regulation of adrenal cortex function in pigs

Cited by 17 publications

References 42 publications

Seasonal changes in the expression of the androgen receptor in the testes of the domestic goose (Anser anser f. domestica)

Seasonal changes in the expression of the androgen receptor in the testes of the domestic goose (Anser anser f. domestica)

Tissue-specific regulation of porcine prolactin receptor expression by estrogen, progesterone, and prolactin

Phytoestrogens alter cortisol and and rostenedione secretion by porcine adrenocortical cells

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