The Involvement of Lipids in Signal Transmission Across Cell Membranes of the Nervous System

Hauser, George

doi:10.1007/978-1-4612-5636-6_2

Neural Membranes 1983

DOI: 10.1007/978-1-4612-5636-6_2

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The Involvement of Lipids in Signal Transmission Across Cell Membranes of the Nervous System

George Hauser

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1983

1986

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Cited by 2 publications

(2 citation statements)

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“…Since the P-receptor-mediated increase of cyclic AMP in pinealocytes after stimulation with fluoro-NAs has been reported (Auerbach and Klein, 1981), we have similarly examined the phosphatidylinositol response in dissociated pineal cells in order to compare the effects of these compounds on pineal al-and Padrenergic receptors and on a-adrenergic receptors in other tissues. Preliminary reports of the findings have appeared (Hauser et al, 1982;Hauser, 1983).…”

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confidence: 96%

Differential Effects of Fluoronorepinephrines on Phosphatidylinositol Turnover in Rat Pinealocytes

Hauser

Kirk

Parks

1983

Journal of Neurochemistry

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(+/-)-Norepinephrines (NAs), substituted with fluorine at positions 2, 5, and 6 of the ring, were compared with the unsubstituted compound with respect to their capacity for eliciting increased incorporation of [32P]orthophosphate into phosphatidylinositol of pinealocytes. 5F-NA and 6F-NA were approximately equipotent with NA, whereas 2F-NA required a higher concentration and gave lower maximum stimulation. Inhibition of these effects by prazosin confirmed the participation of alpha 1-adrenergic receptors. The results are comparable with those reported for alpha 1-adrenergic receptor-mediated events in other systems and different from the beta-adrenergic receptor-mediated elevation of cyclic AMP in pinealocytes. These and earlier results emphasize the importance of the hydroxyl group at position 3 of the ring and at the beta-position of the side chain in catecholamine activation of the pineal alpha-adrenergic receptors, which are involved in alterations of phospholipid metabolism.

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Differential Effects of Fluoronorepinephrines on Phosphatidylinositol Turnover in Rat Pinealocytes

Hauser

Kirk

Parks

1983

Journal of Neurochemistry

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“…Phospholipid, lysophospholipid and fatty acid have been implicated in a variety of cellular functions such as neurotransmission, hormone-receptor binding and ionic transport (Hauser 1982). Although recent work has focussed on the role of these compounds in the sperm acrosome reaction, they may also influence other sperm functions including maturation, metabolism and motility (Mann & Lutwak-Mann 1981).…”

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confidence: 99%

Effect of phosphatidylcholine, lysophosphatidylcholine, arachidonic acid and docosahexaenoic acid on the motility of human sperm

Hong

Shieh

et al. 1986

Int J of Andrology

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Lysophosphatidylcholine, arachidonic acid and docosahexaenoic acid were found to have a concentration-dependent inhibitory effect on the motility of human sperm, whilst phosphatidylcholine had no effect. Seminal plasma attenuated the sperm-immobilizing potencies of these lipids. Because all of the three inhibitors of motility are hydrolytic products of phosphatidylcholine, and the catalytic enzyme, phospholipase A2, is known to be calcium dependent, it is suggested that calcium might inhibit sperm motility by activating phospholipase A2 which in turn releases lysophosphatidylcholine and free fatty acids.

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The Involvement of Lipids in Signal Transmission Across Cell Membranes of the Nervous System

Cited by 2 publications

References 53 publications

Differential Effects of Fluoronorepinephrines on Phosphatidylinositol Turnover in Rat Pinealocytes

Differential Effects of Fluoronorepinephrines on Phosphatidylinositol Turnover in Rat Pinealocytes

Effect of phosphatidylcholine, lysophosphatidylcholine, arachidonic acid and docosahexaenoic acid on the motility of human sperm

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