2001
DOI: 10.1080/09629350123956 View full text |Buy / Rent full text
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Abstract: BACKGROUND: Cell-wall components of Gram-positive and Gram-negative bacteria induce the production of cytokines in human peripheral blood mononuclear cells. These cytokines are the main mediators of local or systemic inflammatory reaction that can contribute to the development of innate immunity. AIMS: This study was performed to analyze the involvement of CD14 molecule in the activation of human monocytes by peptidoglycan monomer (PGM) obtained by biosynthesis from culture fluid of penicillin-treated Brevibac… Show more

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“…The PGN reduced the binding of the biotinylated LPS to LBP and CD14. PGN of some species is known to bind to LBP and CD14 (Rietschel et al, 1998;Muhvic et al, 2001;Weber et al, 2003). As a result, S. sanguinis PGN may inhibit cytokine expression induced by the LPS of periodontopathogens due to inhibition of LPS binding to LBP and CD14.…”
Section: Discussionmentioning
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“…The PGN reduced the binding of the biotinylated LPS to LBP and CD14. PGN of some species is known to bind to LBP and CD14 (Rietschel et al, 1998;Muhvic et al, 2001;Weber et al, 2003). As a result, S. sanguinis PGN may inhibit cytokine expression induced by the LPS of periodontopathogens due to inhibition of LPS binding to LBP and CD14.…”
Section: Discussionmentioning
“…The principal component of the outer membrane of Gram-negative bacteria, lipopolysaccharide (LPS), induces the inflammatory response of an organism (Muhvic et al, 2001). Recognition of LPS by immune cells is the first step in the inflammatory response and, therefore, these cells possess some receptors on their surface for this purpose.…”
mentioning
“…100 In human monocytes, the cytokine release induced by the disaccharide-pentapeptide (GlcNAc-MurNAc-Ala-isoGln-meso-DAP-Ala-Ala) was enhanced by pre-incubation with sCD14, while anti-CD14 mAb blocked these effects. 141 MDP was also shown to bind to mCD14, preventing the binding of soluble PGN. 142 In human gingival epithelial cells, CD14 and LBP, but not LBP alone, enhanced MDP-stimulated activation 143 arguing for a role of CD14 as a possible MDP receptor.…”
Section: Cd14mentioning