The intricate relationship between autoimmunity disease and neutrophils death patterns: a love-hate story

Zhang, Ziwei; Lin, Jianwen; Liu, Lianghu; Zhou, Mengqi; Zhang, Xian‐Zheng; Zhang, Lingling

doi:10.1007/s10495-023-01874-w

Cited by 6 publications

(7 citation statements)

References 189 publications

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“…37,38 ANCA-stimulated neutrophil release nets that contain autoantigens PR3 and MPO. 38 On the contrary, patients with very high ANCA titer have no active disease 39 and the literature review showed that the association between ANCA prevalence and disease activity was not uniform. 39,40 An interesting finding in the present study was that the presence of pANCA had an inverse relationship with anti-SSB/La antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…38 On the contrary, patients with very high ANCA titer have no active disease 39 and the literature review showed that the association between ANCA prevalence and disease activity was not uniform. 39,40 An interesting finding in the present study was that the presence of pANCA had an inverse relationship with anti-SSB/La antibodies. According to Hsieh et al, 41 the antigen SSB/La is expressed on the human polymorphonuclear (PMN) cell surface.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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ANCA in patients with systemic lupus erythematosus. A cross sectional study in Brazilian patients and review of literature

Nisihara,

Vithoft,

Alencar

et al. 2024

Lupus

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Background Antineutrophil cytoplasmatic antibodies (ANCA) have been detected in patients with systemic lupus erythematosus (SLE). In this study, we investigated the presence of ANCA in a sample of Brazilian SLE patients and its possible associations with clinical and serological outcomes. Additionally, we reviewed the literature of on ANCA in SLE. Results The presence of ANCA was detected in 130 patients using indirect immunofluorescence (IIF). The test was positive in 29.9% of the cases (17.6% pANCA and 11.5% cANCA). Male sex and peripheral vasculitis were more prevalent in the ANCA-positive sample. cANCA was associated with lupus anticoagulant and pANCA had a positive association with peripheral vasculitis and a negative association with anti- SSB/La antibodies. In the 22 studies included in the literature review, a wide range of ANCA positivity was found (13% to 81.1% by IIF and 0 to 22.2% by ELISA). ANCA was associated with renal damage in the Asian population. Although other associations have been found in isolated studies, they were not consistently reported. Conclusions The ANCA prevalence found in this Brazilian sample was within the range reported in the literature and these autoantibodies were more frequent in males and in patients with vasculitis. The literature showed controversial results on the association between ANCA and SLE disease activity or clinical characteristics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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ANCA in patients with systemic lupus erythematosus. A cross sectional study in Brazilian patients and review of literature

Nisihara,

Vithoft,

Alencar

et al. 2024

Lupus

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“…251 Various pyroptosis-related inflammasomes, such as NLRP1, NLRP3, AIM2, and NLRC4, have been explored in a variety of autoimmune diseases. 252 The activation of inflammasomes mediates the production of a variety of inflammation-related cytokines, resulting in chronic inflammation, which is one of the main reasons promoting the pathogenesis of autoimmune diseases. 253 For example, the production and activation of IL-1β caused by inflammasomes exist in RA, SLE, and AS.…”

Section: Pyrop Tos Ismentioning

confidence: 99%

A variety of death modes of neutrophils and their role in the etiology of autoimmune diseases

Li,

Wu,

Huang

et al. 2023

Immunological Reviews

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SummaryNeutrophils are important in the context of innate immunity and actively contribute to the progression of diverse autoimmune disorders. Distinct death mechanisms of neutrophils may exhibit specific and pivotal roles in autoimmune diseases and disease pathogenesis through the orchestration of immune homeostasis, the facilitation of autoantibody production, the induction of tissue and organ damage, and the incitement of pathological alterations. In recent years, more studies have provided in‐depth examination of various neutrophil death modes, revealing nuances that challenge conventional understanding and underscoring their potential clinical utility in diagnosis and treatment. This review explores the multifaceted processes and characteristics of neutrophil death, with a focus on tailored investigations within various autoimmune diseases. It also highlights the potential interplay between neutrophil death and the landscape of autoimmune disorders. The review encapsulates the pertinent pathways implicated in various neutrophil death mechanisms across diverse autoimmune diseases while also charts possible avenues for future research.

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“…Autoimmune diseases result in damage to and the destruction of host tissues due to the misrecognition of self-antigens by the immune system. These diseases affect different organs and systems, such as the joints, nervous system, and muscles [1]. Natural killer (NK) cells and T cells are two important types of immune cells of innate and adaptive immunity, respectively.…”

Section: Introductionmentioning

confidence: 99%

The Role of NKG2D and Its Ligands in Autoimmune Diseases: New Targets for Immunotherapy

Wei,

Xiang,

Zou

2023

IJMS

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Natural killer (NK) cells and CD8+ T cells can clear infected and transformed cells and generate tolerance to themselves, which also prevents autoimmune diseases. Natural killer group 2 member D (NKG2D) is an important activating immune receptor that is expressed on NK cells, CD8+ T cells, γδ T cells, and a very small percentage of CD4+ T cells. In contrast, the NKG2D ligand (NKG2D-L) is generally not expressed on normal cells but is overexpressed under stress. Thus, the inappropriate expression of NKG2D-L leads to the activation of self-reactive effector cells, which can trigger or exacerbate autoimmunity. In this review, we discuss the role of NKG2D and NKG2D-L in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type I diabetes (T1DM), inflammatory bowel disease (IBD), and celiac disease (CeD). The data suggest that NKG2D and NKG2D-L play a pathogenic role in some autoimmune diseases. Therefore, the development of strategies to block the interaction of NKG2D and NKG2D-L may have therapeutic effects in some autoimmune diseases.

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The intricate relationship between autoimmunity disease and neutrophils death patterns: a love-hate story

Cited by 6 publications

References 189 publications

ANCA in patients with systemic lupus erythematosus. A cross sectional study in Brazilian patients and review of literature

ANCA in patients with systemic lupus erythematosus. A cross sectional study in Brazilian patients and review of literature

A variety of death modes of neutrophils and their role in the etiology of autoimmune diseases

The Role of NKG2D and Its Ligands in Autoimmune Diseases: New Targets for Immunotherapy

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