2024
DOI: 10.3390/pathogens13030187
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The Intricate Interplay between APOBEC3 Proteins and DNA Tumour Viruses

Nika Lovšin,
Bhavani Gangupam,
Martina Bergant Marušič

Abstract: APOBEC3 proteins are cytidine deaminases that play a crucial role in the innate immune response against viruses, including DNA viruses. Their main mechanism for restricting viral replication is the deamination of cytosine to uracil in viral DNA during replication. This process leads to hypermutation of the viral genome, resulting in loss of viral fitness and, in many cases, inactivation of the virus. APOBEC3 proteins inhibit the replication of a number of DNA tumour viruses, including herpesviruses, papillomav… Show more

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Cited by 3 publications
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