2012
DOI: 10.1039/c2dt11864e
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Abstract: The unique properties exhibited by nanoscale materials, coupled with the multitude of chemical surface derivatisation possibilities, enable the rational design of multifunctional nanoscopic devices. Such functional devices offer exciting new opportunities in medical research and much effort is currently invested in the area of "nanomedicine", including: multimodal imaging diagnostic tools, platforms for drug delivery and vectorisation, polyvalent, multicomponent vaccines, and composite devices for "theranostic… Show more

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Cited by 101 publications
(96 citation statements)
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“…28 In addition, the amino or azido end groups can be coupled to biomolecules though peptide type coupling or copper-catalyzed [3+2] cycloadditions (click reactions). Other anchoring moieties such as carboxylates, phosphonates and catechol ligands, in particular dopamine-based derivatives, have been conjugated to nanoparticulate iron oxides 29 to increase long-term colloidal stability in biological medium 30 and to display multifunctional surfaces. 31 Nevertheless, Fe(III)-mediated oxidation of catechol ligands might induce loss of colloidal stability and produce cytotoxic iron-quinone complexes.…”
Section: -25mentioning
confidence: 99%
“…28 In addition, the amino or azido end groups can be coupled to biomolecules though peptide type coupling or copper-catalyzed [3+2] cycloadditions (click reactions). Other anchoring moieties such as carboxylates, phosphonates and catechol ligands, in particular dopamine-based derivatives, have been conjugated to nanoparticulate iron oxides 29 to increase long-term colloidal stability in biological medium 30 and to display multifunctional surfaces. 31 Nevertheless, Fe(III)-mediated oxidation of catechol ligands might induce loss of colloidal stability and produce cytotoxic iron-quinone complexes.…”
Section: -25mentioning
confidence: 99%
“…2728 A major advantage to capping SPIONs with catechol-functionalized polymers is the improved magnetic properties, 29 which increases T2 contrast enhancement in MR imaging. SPIONs have a large proportion of under-coordinated atoms on the particle surface due to the large surface-area-to-volume ratio inherent to particles at this size.…”
Section: Resultsmentioning
confidence: 99%
“…47 Bidentate binding of catechol to under-coordinated Fe(III)-surface sites led to the surface restructuring of Fe 3 O 4 , recreating the bulk -Fe 2 O 3 structure. 48 Hence, the interfacial interactions resulted in small traces of Fe 3þ present in the nanoparticle. As shown in Fig.…”
Section: -5mentioning
confidence: 99%