The interplay between vitamin C and thyroid

Farasati Far, Bahareh; Behnoush, Amir Hossein; Ghondaghsaz, Elina; Habibi, Mohammad Amin; Khalaji, Amirmohammad

doi:10.1002/edm2.432

Cited by 10 publications

(3 citation statements)

References 79 publications

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“…Vitamin C has multiple benefits for several diseases. In a review, vitamin C was reported to increase the death of cancerous cells by inhibiting BCL-2(B-cell lymphoma-2) expression and increasing the expression of BAX (BCL2-Association X) and caspase-3 18 . A cross-sectional study involving 5145 participants showed an inverse association between vitamin C intake and periodontitis 19 .…”

Section: Discussionmentioning

confidence: 99%

Association between vitamin C in serum and trouble sleeping based on NHANES 2017–2018

Wang,

Lai,

Zhao

et al. 2024

Sci Rep

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Vitamin C is an important micronutrient for human. Association between vitamin C and trouble sleeping was less studied. Therefore, the purpose of this study was to investigate the possible link between vitamin C in serum and trouble sleeping. The cross-sectional data was derived from the National Health and Nutrition Examination Survey (NHANES, 2017–2018). Trouble sleeping was measured by asking participants: “Have you ever told doctor had trouble sleeping”. Responses to this question was “yes” or “no”. vitamin C in serum was obtained by measuring the serum samples. We used multivariable binary logistic regressions to examine the possible link between vitamin C in serum and trouble sleeping, and then a subgroup analysis was performed. Moreover, the non-linear relationship between vitamin C in serum and trouble sleeping was further detected using a restricted cubic spline (RCS) model. A total of 3227 participants were included in the study. After adjusting all potential confounders, the results of multivariable logistic regression showed the significant negative association between vitamin C in serum and trouble sleeping(OR = 0.816; 95% CI:0.669 ~ 0.995). The significant inverse association was also found in female(OR = 0.713; 95% CI:0.546 ~ 0.931), age ≤ 65 years(OR = 0.773; 95% CI:0.600 ~ 0.996), and in participants with high cholesterol level(OR = 0.738; 95% CI:0.548 ~ 0.994). In addition, the RCS model demonstrated the significant non-linear relationship between vitamin C in serum and trouble sleeping (P value of nonlinear = 0.010). Our study demonstrates the significant negative association between vitamin C in serum and trouble sleeping.

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Section: Discussionmentioning

confidence: 99%

Association between vitamin C in serum and trouble sleeping based on NHANES 2017–2018

Wang,

Lai,

Zhao

et al. 2024

Sci Rep

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“…Studies on primary cultures of orbital fibroblasts from TAO patients have shown that vitamin C, N-acetylcysteine and melatonin reduce H 2 O 2 -stimulated glutathione disulphide (GSSG) release, potentially benefiting orbital lesion treatment ( 130 ). Additionally, vitamin C and E supplementation improved clinical symptoms and clinical scores in TAO patients by reducing oxidative stress markers ( 131 ). These antioxidants inhibit TAO fibroblast proliferation, with N-acetylcysteine and melatonin selectively blocking IFN-γ release ( 132 ).…”

Section: Therapeutic Agents For Oxidative Stress In Tao and Their Pot...mentioning

confidence: 99%

Thyroid-associated ophthalmopathy: the role of oxidative stress

Ma,

Li,

et al. 2024

Front. Endocrinol.

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Thyroid-associated ophthalmopathy (TAO) is an autoimmune condition affecting the eyes, characterized by proptosis, extraocular muscle involvement, and in severe cases, vision impairment including diplopia, optic neuropathy, and potential blindness. The exact etiology of TAO remains elusive; however, increased oxidative stress and decreased antioxidant capacity are pivotal in its pathogenesis. Elevated oxidative stress not only directly damages orbital tissues but also influences thyroid function and autoimmune responses, exacerbating tissue destruction. This review explores the role of oxidative stress in TAO, elucidates its mechanisms, and evaluates the efficacy and limitations of antioxidant therapies in managing TAO. The findings aim to enhance understanding of oxidative stress mechanisms in TAO and propose potential antioxidant strategies for future therapeutic development.

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“…Vitamins C and E have a strong ability to regulate REDOX. Studies have shown that vitamins C and E can improve oxidative damage in patients with thyroid diseases ( 8 , 9 ). In 1994, Berg discovered the expression of vitamin D receptors on thyroid follicular cells in rats, suggesting that vitamin D may be involved in the pathophysiological processes of the thyroid ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Association of circulating vitamin levels with thyroid diseases: a Mendelian randomization study

Zhang,

Liu,

Que

2024

Front. Endocrinol.

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BackgroundPrevious observational studies have shown conflicting results of vitamins supplementation for thyroid diseases. The causal relationships between vitamins and thyroid diseases are unclear. Therefore, we conducted a two-sample bidirectional Mendelian randomization (MR) study to explore association of circulating vitamin levels with thyroid diseases.MethodsWe performed a bidirectional MR analysis using genome-wide association study (GWAS) data. Genetic tool variables for circulating vitamin levels include vitamins A, B9, B12, C, D, and E, Genetic tool variables of thyroid diseases include autoimmune hyperthyroidism, autoimmune hypothyroidism, thyroid nodules (TNs), and Thyroid cancer (TC). Inverse-variance weighted multiplicative random effects (IVW-RE) was mainly used for MR Analysis, weighted median (WM) and MR Egger were used as supplementary methods to evaluate the relationships between circulating vitamin levels and thyroid diseases. Sensitivity and pluripotency were evaluated by Cochran’s Q test, MR-PRESSO, Radial MR, MR-Egger regression and leave-one-out analysis.ResultsPositive MR evidence suggested that circulating vitamin C level is a protective factor in autoimmune hypothyroidism (ORIVW-RE=0.69, 95%CI: 0.58-0.83, p = 1.05E-04). Reverse MR Evidence showed that genetic susceptibility to autoimmune hyperthyroidism is associated with reduced level of circulating vitamin A(ORIVW-RE = 0.97, 95% CI: 0.95–1.00, p = 4.38E-02), genetic susceptibility of TNs was associated with an increased level of circulating vitamin D (ORIVW-RE = 1.02, 95% CI: 1.00–1.03, p = 6.86E-03). No causal and reverse causal relationship was detected between other circulating vitamin levels and thyroid diseases.ConclusionOur findings provide genetic evidence supporting a bi-directional causal relationship between circulating vitamin levels and thyroid diseases. These findings provide information for the clinical application of vitamins prevention and treatment of thyroid diseases.

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The interplay between vitamin C and thyroid

Cited by 10 publications

References 79 publications

Association between vitamin C in serum and trouble sleeping based on NHANES 2017–2018

Association between vitamin C in serum and trouble sleeping based on NHANES 2017–2018

Thyroid-associated ophthalmopathy: the role of oxidative stress

Association of circulating vitamin levels with thyroid diseases: a Mendelian randomization study

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