The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology

Adams, Michael A.; Dolan, Patricia; McNally, Donal

doi:10.1016/j.matbio.2009.06.004

Cited by 104 publications

(76 citation statements)

References 53 publications

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“…La diversidad de resultados de estas investigaciones sugiere que ambos factores, el genético y el mecánico, son importantes en la degeneración del disco intervertebral (Adams et al 2009;Adams 2012), proceso que posteriormente da lugar a la formación de osteofitos (Kumaresan et al 2001). En consecuencia, aunque quizás no se pueda llegar a conocer el tipo de actividades específicas que originan la patología (Jurmain 1990), este tipo de estudios entrega información acerca de la intensidad del estrés aplicado a esta estructura anatómica producto de distintos factores, incluyendo el cultural, reflejado en las actividades físicas y/o productivas -en su sentido más amplio-realizadas por un grupo humano en particular.…”

Section: Osteofitosis Vertebralunclassified

Osteofitosis Vertebral en Poblaciones Prehispánicas De San Pedro De Atacama, Norte De Chile

López-Barrales¹,

Hübbe

Aspillaga

et al. 2015

Estud. atacam.

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ResumenSe estudió la osteofitosis vertebral como indicador de estrés físico en grupos humanos prehistóricos de San Pedro de Atacama, durante los períodos Medio (400 DC -1000 DC) e Intermedio Tardío (1000 DC -1450 DC). Se registró el grado promedio de osteofitosis vertebral de cada segmento vertebral en 154 individuos adultos de cuatro sitios: Solcor 3, Coyo 3, Quitor 6 y Toconao Oriente. Se comprobó el carácter degenerativo de la osteofitosis vertebral, ya que el grado promedio de osteofitosis fue mayor en el rango etario más viejo. Se observaron diferencias significativas entre sitios sólo en este rango. No se encontraron diferencias en el grado de osteofitosis entre sexos. Los resultados indicaron que durante el período Intermedio Tardío, tanto hombres como mujeres, sufrieron un estrés físico sobre la espalda menor que las poblaciones que vivieron durante el período Medio, especialmente a finales de este período, posiblemente por cambios en los patrones de actividad, ya sea en la energía invertida en sus actividades y por consecuencia, en la intensidad de las actividades físicas desarrolladas, o en diferencias en el tipo de actividades desarrolladas.Palabras claves: bioarqueología -estrés físico -período Medio -período Intermedio Tardío.Abstract Vertebral osteophytosis was studied as a marker for physical stress in prehistoric populations of San Pedro de Atacama from the Middle (400 -1.000 A.D.) and Late Intermediate (1.000 -1.450 A.D.) periods. The mean degree of osteophytosis was recorded in each vertebral segment of 154 individuals from four sites: Solcor 3, Coyo 3, Quitor 6 and Toconao Oriente. Osteophytosis prevalence was more severe in older individuals, corroborating its degenerative nature. However, after correction for age impact in osteophytosis prevalence, significant differences were observed between sites. Differences in osteophytosis prevalence between sexes were not significant. The results show that during the Late Intermediate period populations of both sexes suffered less vertebral stress than during the Middle period, particularly during the its end. Changes in activity patterns (amount of energy invested, intensity or type of activities undertaken) could account for the differences found.

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Section: Osteofitosis Vertebralunclassified

Osteofitosis Vertebral en Poblaciones Prehispánicas De San Pedro De Atacama, Norte De Chile

López-Barrales¹,

Hübbe

Aspillaga

et al. 2015

Estud. atacam.

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“…Plowing has been extensively investigated in the temporomandibular joint (TMJ), in particular in its fibrocartilaginous disc, which is subject to compression by the underlying mandibular condyle that in general translates and rotates simultaneously (Donzelli et al, 2004;Mow et al, 1993;Nickel et al, 2009;Adams et al, 2009;Detamore and Athanasiou, 2003;Singh and Detamore, 2009;Tanaka, 2003). In our previous work, the complex TMJ disc deformation, and thus indirectly its loading, has been studied quantitatively from in vivo data by coupling magnetic resonance imaging (MRI) and jaw-tracking of human subjects (Gallo et al, 2000;Gallo, 2005;Gallo et al, 2006;Palla et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Coupling plowing of cartilage explants with gene expression in models for synovial joints

Correro-Shahgaldian

Colombo

Spencer

et al. 2011

Journal of Biomechanics

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Articular cartilage undergoes complex loading modalities generally including sliding, rolling and plowing (i.e. the compression by a condyle normally to the tissue surface under simultaneously tangential displacement, thus generating a tractional force due to tissue deformation). Although in in vivo studies it was shown that excessive plowing can lead to osteoarthritis, little quantitative experimental work on this loading modality and its mechanobiological effects is available in the literature. Therefore, a rolling/plowing explant test system has been developed to study the effect on pristine cartilage of plowing at different perpendicular forces. Cartilage strips harvested from bovine nasal septa of 12-months-old calves were subjected for 2h to a plowing-regime with indenter normal force of 50 or 100 N and a sliding speed of 10 mm s(-1). 50 N produced a tractional force of 1.2±0.3N, whereas 100 N generated a tractional force of 8.0±1.4N. Furthermore, quantitative-real-time polymerase chain reaction experiments showed that TIMP-1 was 2.5x up-regulated after 50 N plowing and 2x after 100 N plowing, indicating an ongoing remodeling process. The expression of collagen type-I was not affected after 50 N plowing but it was up-regulated (6.6x) after 100 N plowing, suggesting a possible progression to an injury stage of the cartilage, as previously reported in cartilage of osteoarthritic patients. We conclude that plowing as performed by our mimetic system at the chosen experimental parameters induces changes in gene expression depending on the tractional force, which, in turn, relates to the applied normal force. . 50 N produced a tractional force of 1.2 ± 0.3 N, whereas 100 N generated a tractional force of 8.0 ± 1.4 N. Furthermore, quantitativereal-time polymerase chain reaction experiments showed that TIMP-1 was 2.5x upregulated after 50 N plowing and 2x after 100 N plowing, indicating an ongoing remodeling process. The expression of Collagen type I was not affected after 50 N plowing but it was up-regulated (6.6x) after 100 N plowing, suggesting a possible progression to an injury stage of the cartilage, as previously reported in cartilage of osteoarthritic patients. We conclude that plowing as performed by our mimetic system at the chosen experimental parameters induces changes in gene expression depending on the tractional force, which, in turn, relates to the applied normal force.

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“…The major structural components of the macromolecule are collagens and proteoglycans [8]. It is estimated that the ratio of type II collagen and the proteoglycan aggrecan in the AF is 1:20 [9].…”

Section: The Shielded Structure and Rigid Environment Of Intervertebrmentioning

confidence: 99%

“…It is estimated that the ratio of type II collagen and the proteoglycan aggrecan in the AF is 1:20 [9]. Collagens provide firm and tensile strength whereas proteoglycans, through interactions with water, give the tissues stiffness, viscoelasticity and resistance to compression [8,9]. Collagenous proteins comprise 70% of the outer annulus dry weight, but only account for 20% of NP [8,9].…”

Section: The Shielded Structure and Rigid Environment Of Intervertebrmentioning

confidence: 99%

“…Collagens provide firm and tensile strength whereas proteoglycans, through interactions with water, give the tissues stiffness, viscoelasticity and resistance to compression [8,9]. Collagenous proteins comprise 70% of the outer annulus dry weight, but only account for 20% of NP [8,9]. On the contrary, NP has a higher proteoglycan concentration, with up to 50% of the nucleus dry weight in adolescence.…”

Section: The Shielded Structure and Rigid Environment Of Intervertebrmentioning

confidence: 99%

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Mesenchymal Stem Cell in the Intervertebral Disc

Long¹,

Liang²,

Liu³

et al. 2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

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Degeneration of the intervertebral disc (IVD) is a major spinal disorder that causes back pain. Nucleus pulposus (NP) in the central of IVD dehydrates and become more fibrous in the IVD degeneration. NP cells undergo apoptosis with the degeneration of extracellular matrix (ECM) components. To replenish the NP cells and core ECM, bone marrow mesenchymal stromal cells (BMSCs) have been highlighted in the regeneration of IVD degeneration. BMSCs differentiate into NP-like cells with the secretion of ECM components, which may not only replenish the number of NP cells but also stimulate NP reconstruction. This further maintains tissue homeostasis. Up to date, the disc progenitor cells (DPCs) have been identified with the characteristics of multidifferentiation and stem cell phenotype. These cells are involved in the IVD diseases and show regenerative potentials. However, the differences between the BMSCs and DPCs remain elusive, in particular, the cellular connection in vivo. As such, this chapter will discuss the findings of the two cell types and propose a novel concept in the understanding of the biology of IVD.

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The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology

Cited by 104 publications

References 53 publications

Osteofitosis Vertebral en Poblaciones Prehispánicas De San Pedro De Atacama, Norte De Chile

Osteofitosis Vertebral en Poblaciones Prehispánicas De San Pedro De Atacama, Norte De Chile

Coupling plowing of cartilage explants with gene expression in models for synovial joints

Mesenchymal Stem Cell in the Intervertebral Disc

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