2012
DOI: 10.1016/s0140-6736(12)60110-x
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Abstract: SummaryBackgroundA high circulating concentration of interleukin 6 is associated with increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a monoclonal antibody (tocilizumab) licensed for treatment of rheumatoid arthritis reduces systemic and articular inflammation. However, whether IL6R blockade also reduces risk of coronary heart disease is unknown.MethodsApplying the mendelian randomisation principle, we used single nucleotide polymorphisms (SNPs) in the gene IL6R to … Show more

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Cited by 861 publications
(360 citation statements)
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References 47 publications
(38 reference statements)
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“…On the other hand, these pathways are also likely to be involved in the detrimental effects of heavy drinking. These observations are concordant with large‐scale Mendelian randomization studies that have shown that inhibiting IL‐6 signalling could reduce the risk of developing CHD 53 whilst inhibiting IL‐1 α/β may increase the risk of CHD 26. This highlights not only the complexity of inflammatory pathways underlying CVDs but also the complicated role of alcohol consumption in the development of such diseases.…”
Section: Discussionsupporting
confidence: 81%
See 1 more Smart Citation
“…On the other hand, these pathways are also likely to be involved in the detrimental effects of heavy drinking. These observations are concordant with large‐scale Mendelian randomization studies that have shown that inhibiting IL‐6 signalling could reduce the risk of developing CHD 53 whilst inhibiting IL‐1 α/β may increase the risk of CHD 26. This highlights not only the complexity of inflammatory pathways underlying CVDs but also the complicated role of alcohol consumption in the development of such diseases.…”
Section: Discussionsupporting
confidence: 81%
“…In terms of overall effect sizes, the multivariable‐adjusted effect of stable nondrinking on the intercept of IL‐6 is equivalent to the per‐allele effect of single nucleotide polymorphism (SNP) rs7529229 in the IL6R gene (Ch1q21.3) on IL‐6 levels 53 which confers an approximately 5% reduction in odds of developing CHD. CRP levels were increased by 15.7% in nondrinkers compared to stable moderate drinkers, which is similar to the per‐allele difference observed for CRP SNP rs1130864 59.…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, Gupta et al reported that the association between CRP and atherosclerosis is diminished in obese persons aged 30 to 65 years 35. The role of interleukin 6 was recently corroborated by 3 mendelian‐based association studies 36, 37, 38. Single‐nucleotide polymorphisms associated with decreased interleukin 6 signaling were found to correlate with lower values of acute‐phase reactants, such as CRP and fibrinogen, with a concomitant proportional reduction in cardiovascular risk.…”
Section: Discussionmentioning
confidence: 89%
“…Этот полиморфизм кор-релирует с уровнем сывороточного рецептора ИЛ6 и ассо-циирован со сниженным риском развития сердечно-сосу-дистых заболеваний [64,65]. В нашем исследовании не было обнаружено выраженной негативной ассоциации РРА с минорной аллелью С и гомозиготным генотипом СС, но в наших предыдущих исследованиях [59,60] у больных с высокой воспалительной активностью, лечен-ных тоцилизумабом и ритуксимабом, частоты генотипа СС были существенно снижены по сравнению с контро-лем (9,3; 1,5 и 17,5% соответственно).…”
Section: Mcp1/ccl2 Icam1unclassified