The interleukin-1β-511 T>C (rs16944) gene polymorphism is associated with risk of developing silent myocardial ischemia in diabetic patients

Clinical phenotype of recurrent aphthous stomatitis and interleukin‐1β genotype in a Polish cohort of patients

“…Three polymorphisms related to a transition between C and T at positions, −511 (T→C), −31 (T→C) and +3954 (C→T), have been widely described and associated with a risk of several systemic disorders. In previous reports, IL‐1β gene polymorphisms have been implicated in the increased production of cytokines and an elevated risk of RAS and Behçet's disease .…”

“…The IL‐1 cytokine family, which consists of 11 individual members, includes IL‐1α, IL‐1β and IL‐1 receptor antagonist (IL‐1Ra). These proteins are encoded by a gene cluster located on a chromosome 2q14 . Three polymorphisms related to a transition between C and T at positions, −511 (T→C), −31 (T→C) and +3954 (C→T), have been widely described and associated with a risk of several systemic disorders.…”

Biochemical and molecular study on interleukin‐1β gene expression and relation of single nucleotide polymorphism in promoter region with Type 2 diabetes mellitus

“…Moreover, the gene transcript of IL1-β was dominantly higher in T2DM than healthy subjects which prove the possible immune modulating role of IL1-β in T2DM. Interestingly, C/C genotype of IL1-β −511 T>C polymorphism, was associated with risk of developing diabetes and glucose homeostasis in Finnish population Luotola et al 25 with risk of silent myocardial infarction in diabetic patients, Vargas-Alarcón et al 21 with ulcerative colitis in Mexican population Yamamoto-Furusho et al 17 with risk of coronary artery disease Rechciński et al 26 and with a higher susceptibility to febrile seizures in Egyptian children Abdel Rasol et al 27 However, previous studies carried in Indian population showed association of IL1β TT genotype and T allele with higher risk of diabetes 20,28 the discrepancy of risk allele might be attributed to ethnic variation, genetic background, and environmental determinants.…”

“…Interestingly, C/C genotype of IL1‐β −511 T>C polymorphism, was associated with risk of developing diabetes and glucose homeostasis in Finnish population Luotola et al with risk of silent myocardial infarction in diabetic patients, Vargas‐Alarcón et al with ulcerative colitis in Mexican population Yamamoto‐Furusho et al with risk of coronary artery disease Rechciński et al and with a higher susceptibility to febrile seizures in Egyptian children Abdel Rasol et al…”

“…15,16 The IL-1 β −511 T>C single nucleotide polymorphism (SNP) in the promoter region has been identified in the 5′−flanking region of the IL-1 β gene, this SNP has been related with the promoter activity, and with risk of diseases including ulcerative colitis, diabetes nephropathy, rheumatoid arthritis, T2DM, and myocardial infarction. [17][18][19][20][21] Past studies indicated controversial outcomes about association of interleukin-1β with T2DM so we pointed in this research to investigate gene expression of Interleukin-1β and its connection with SNP in its promoter region at position −511 (rs16944) and its conceivable relation with susceptibility to T2DM in Egyptian patients.…”