The interface between glial progenitors and gliomas

Canoll, Peter; Goldman, James E.

doi:10.1007/s00401-008-0432-9

Cited by 107 publications

(92 citation statements)

References 106 publications

(129 reference statements)

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“…48 Thus, microRNAs play important roles in development, and may also strongly influence the behavior of neural stem and progenitor cells -these are the normal cell types thought to be most similar biologically to glial tumor cells. 21,49 …”

Section: Micrornas In Neural Developmentmentioning

confidence: 99%

MicroRNAs and glioblastoma; the stem cell connection

et al. 2009

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Recent data draw close parallels between cancer, including glial brain tumors, and the biology of stem and progenitor cells. At the same time, it has become clear that one of the major roles that microRNAs play is in the regulation of stem cell biology, differentiation, and cell 'identity'. For example, microRNAs have been increasingly implicated in the regulation of neural differentiation. Interestingly, initial studies in the incurable brain tumor glioblastoma multiforme strongly suggest that microRNAs involved in neural development play a role in this disease. This encourages the idea that certain miRs allow continued tumor growth through the suppression of differentiation and the maintenance of the stem cell-like properties of tumor cells. These concepts will be explored in this article.

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Section: Micrornas In Neural Developmentmentioning

confidence: 99%

MicroRNAs and glioblastoma; the stem cell connection

et al. 2009

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“…1B,C) (Albert and Riddle, 1983). Glia are the most abundant cell type in the human brain, and glia contribute extensively to nervous system disease (Canoll and Goldman, 2008;Ozawa et al, 1994;Shaham, 2005). However, the roles played by glia in the nervous system remain largely mysterious.…”

Section: Introductionmentioning

confidence: 99%

Glia delimit shape changes of sensory neuron receptive endings in C. elegans

2011

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SUMMARYNeuronal receptive endings, such as dendritic spines and sensory protrusions, are structurally remodeled by experience. How receptive endings acquire their remodeled shapes is not well understood. In response to environmental stressors, the nematode Caenorhabditis elegans enters a diapause state, termed dauer, which is accompanied by remodeling of sensory neuron receptive endings. Here, we demonstrate that sensory receptive endings of the AWC neurons in dauers remodel in the confines of a compartment defined by the amphid sheath (AMsh) glial cell that envelops these endings. AMsh glia remodel concomitantly with and independently of AWC receptive endings to delimit AWC receptive ending growth. Remodeling of AMsh glia requires the OTD/OTX transcription factor TTX-1, the fusogen AFF-1 and probably the vascular endothelial growth factor (VEGFR)-related protein VER-1, all acting within the glial cell. ver-1 expression requires direct binding of TTX-1 to ver-1 regulatory sequences, and is induced in dauers and at high temperatures. Our results demonstrate that stimulus-induced changes in glial compartment size provide spatial constraints on neuronal receptive ending growth.

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“…1 It has been hypothesized that gliomas arise from endogenous glial progenitor or neural stem cells, 2 with which they share the ability to migrate along white matter tracts and perivascular and subpial spaces. 3 As a consequence, malignant gliomas are highly infiltrative tumors for which complete surgical resection is not feasible.…”

Section: Introductionmentioning

confidence: 99%

Evaluation and optimization of the administration of a selectively replicating herpes simplex viral vector to the brain by convection-enhanced delivery

et al. 2011

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The direct intraparenchymal administration of oncolytic viral vectors by convection-enhanced delivery (CED) represents a promising new treatment strategy for malignant gliomas. However, there is no evidence to suggest that oncolytic viruses as large as herpes simplex virus-1 (HSV-1) can be administered by CED, as this has not been systematically examined in an animal model. In this study, the administration of a herpes simplex viral vector, HSV1, has been evaluated in detail in the gray and white matter of both rat and pig models, using high flow-rate infusions, co-infusing heparin or preinfusing the tissue with an isotonic albumin solution. Rat HSV-1 infusions at both slow (0.5 ml min À1 ) and high infusion rates (2.5 ml min À1 ) led to extensive tissue damage and negligible cell transduction. Co-infusion with heparin led to extensive hemorrhage. Preinfusion of tissue with an isotonic albumin solution facilitated widespread vector distribution and cell transduction in white matter only. Using this approach in pig brain led to widespread vector distribution with extensive transduction of astrocytes and activated microglia. In rat brain, enhanced green fluorescent protein expression peaked 48 h after vector administration and was associated with a vigorous immune response. These findings indicate that direct infusions of HSV-1-based viral vectors into the brain lead to minimal vector distribution, negligible cell transduction and extensive damage. Tissue preinfusion with an isotonic solution prior to vector administration represents an effective technique for achieving widespread HSV-1 distribution.

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The interface between glial progenitors and gliomas

Cited by 107 publications

References 106 publications

MicroRNAs and glioblastoma; the stem cell connection

MicroRNAs and glioblastoma; the stem cell connection

Glia delimit shape changes of sensory neuron receptive endings in C. elegans

Evaluation and optimization of the administration of a selectively replicating herpes simplex viral vector to the brain by convection-enhanced delivery

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