The intercellular adhesion molecule‐1 (ICAM‐1) gene K469E polymorphism is not associated with ischaemic heart disease: an investigation using family‐based tests of association

McGlinchey, Paul G.; Spence, Mark S.; Patterson, Christopher; Allen, Adrian; Murphy, Gillian; Belton, Christine; McKeown, Pascal

doi:10.1111/j.1365-2370.2004.00474.x

Cited by 17 publications

(13 citation statements)

References 39 publications

(48 reference statements)

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“…Previously, it was demonstrated that GG genotype of rs5498 may be related to a greater risk of the peripheral artery occlusive disease [10]. Some authors did not observe an association between rs5498 and myocardial infarction or ischemic heart disease [23][24][25]. The role of rs5498 polymorphism has been investigated in other inflammatory or immunological diseases in different populations [17,22,26,27].…”

Section: Discussionmentioning

confidence: 99%

Interactions between rs5498 polymorphism in the ICAM1 gene and traditional risk factors influence susceptibility to coronary artery disease

2008

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Coronary artery disease (CAD) depends on multiple genetic and environmental factors. Adhesion molecules are markers of endothelium dysfunction. Intercellular adhesion molecule-1 (ICAM-1) interacts with leukocyte integrins and promotes atherosclerotic process at the surface of endothelial cells. The aim of the study was to assess the association between ICAM1 rs5498 polymorphism and CAD and to establish whether there are any interactions between this polymorphism and traditional risk factors in determining the risk of CAD. We studied 191 cases with angiographically documented CAD and 203 controls with no signs of cardiovascular diseases. The ICAM1 polymorphism was genotyped using PCR-RFLP method. Data were analyzed with the STATISTICA 7.1 and EpiInfo 6 softwares. We did not observe significant differences in the distribution of genotypes and alleles of rs5498 between cases and controls. We only found a tendency to a higher prevalence of G allele carriers (AG + GG) in patients compared to controls (68 vs. 64%, P = 0.399). A synergistic effect of G allele carrier-state and smoking that had influenced the risk of CAD [synergy index multiplicative (SIM = 2.09)] was observed. Smoking carriers of G allele compared to non-smoking AA were more prevalent in CAD group (39.8%) than among controls (13.3%, P < 0.0001, OR 4.81). Moreover, there was also a synergistic effect between G allele carrier-state and an elevated level of triacylglycerols (TG) (SIM = 1.28) increasing the risk of CAD. There is a synergistic interaction between rs5498 genotype and smoking that increases the risk of CAD.

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Section: Discussionmentioning

confidence: 99%

Interactions between rs5498 polymorphism in the ICAM1 gene and traditional risk factors influence susceptibility to coronary artery disease

2008

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“…On the other hand, McGlinchey et al [26] found no association between the K469E polymorphism in the ICAM-1 gene and CHD in a well-defined Irish population. Also in a study of 303 Iranian patients with angiographically documented CAD, no association was found between K469E polymorphism and CHD and MI [27].…”

Section: Discussionmentioning

confidence: 96%

The intercellular adhesion molecule-1 (ICAM-1) gene polymorphism K469E in end-stage renal disease patients with cardiovascular disease

et al. 2012

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“…Mc Glinchey et al [34] found no association between the ICAM-1 K469E polymorphism and CHD in a well-defined Irish population; Aminian et al [35] failed to find any significant differences between CHD patients and controls regarding KK genotype, despite of their high frequencies in CHD patients in a population from Fars province, Iran; and a Slovenian study reported that the K469E polymorphism of the ICAM-1 gene was not associated with MI in subjects with diabetes mellitus [36]. …”

Section: Discussionmentioning

confidence: 99%

Genetic variations in E-selectin and ICAM-1: Relation to Atherosclerosis

et al. 2012

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SummaryBackgroundThis study aimed to investigate the association of both intercellular adhesion molecule-1 (ICAM-1) and endothelial cell adhesion molecule (E-selectin) polymorphisms using PCR technique and their role in the pathogenesis of atherosclerosis.Material/MethodsThe study enrolled 285 individuals, classified into 4 groups: 63 cerebrovascular atherosclerotic patients, 75 cardiovascular patients, 72 peripheral atherosclerotic patients and 75 normal healthy individuals.ResultsThe frequency of the mutant AC genotype of E-selectin in peripheral, cerebral and cardiovascular atherosclerotic patients was significantly higher than in control subjects (29.17%, 28.53% and 28% vs. 8%, respectively). However, no significant difference was observed in the frequency of mutant CC allele between all atherosclerotic patients and control groups. The frequency of the mutant EE homozygotes of ICAM-1 in peripheral, cerebral and cardiovascular atherosclerotic patients was significantly higher compared to controls (45.8%, 42.9% and 36% vs. 12%, respectively). The frequency of EK of ICAM-1 showed no significant difference between atherosclerotic patients and the control group. The frequency of the mutant E allele of ICAM-1 was significantly higher in peripheral, cerebral and cardiovascular patients compared to controls (58.3%, 54.8% and 54% vs. 26%, respectively).ConclusionsSer 128Arg of E-selectin and the K469E of ICAM-1 polymorphisms may be involved in predisposition to atherosclerosis.

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The intercellular adhesion molecule‐1 (ICAM‐1) gene K469E polymorphism is not associated with ischaemic heart disease: an investigation using family‐based tests of association

Cited by 17 publications

References 39 publications

Interactions between rs5498 polymorphism in the ICAM1 gene and traditional risk factors influence susceptibility to coronary artery disease

Interactions between rs5498 polymorphism in the ICAM1 gene and traditional risk factors influence susceptibility to coronary artery disease

The intercellular adhesion molecule-1 (ICAM-1) gene polymorphism K469E in end-stage renal disease patients with cardiovascular disease

Genetic variations in E-selectin and ICAM-1: Relation to Atherosclerosis

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