The interactive effects of irrigation, nitrogen fertilisation rate, delayed harvest and storage on the polyphenol content in red grape (Vitis vinifera) berries: A factorial experimental design

Cavaliere, Chiara; Foglia, Patrizia; Marini, Federico; Samperi, Roberto; Antonacci, Donato; Laganà, Aldo

doi:10.1016/j.foodchem.2010.03.112

Cited by 22 publications

(22 citation statements)

References 18 publications

(26 reference statements)

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“…Consumption of foods with high GSE content is widely marketed as a dietary supplement and it is considered safe for human health (15) . Nevertheless, the analytical composition of GSE from different sources and namely from different grape cultivars, growing in special agronomic constraints, differs greatly in tannin content, as we have previously shown (16) . The major concern with GSE studies is a lack of availability of uniformly standardised preparations.…”

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confidence: 79%

Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2

Dinicola

Cucina²,

Pasqualato

et al. 2010

Br J Nutr

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Consumption of grape seed extract (GSE) is widely marketed as a dietary supplement and is considered safe for human health. Nevertheless, the analytical composition of GSE from different grape cultivars, growing in special agronomic constraints, differs greatly in flavan-3-ols content. The major concern with GSE studies is a lack of availability of uniformly standardised preparations, which raises an important question whether different GSE samples have comparable activity and trigger the same mechanisms of action on a given biological system. Therefore, it is tempting to speculate that GSE, obtained from different cultivars, could exert differentiated anticancer effects. The focus of the present study is to determine the selective biological efficacy of GSE obtained from three different sources on the human colon cancer cell line Caco-2. Irrespective of its source, high doses of GSE induced a significant inhibition on Caco-2 cell growth. Moreover, apoptosis was enhanced through both caspase-dependent and caspase-independent mechanisms, leading to an early apoptosis-inducing factor release and, further, to a dramatic increase in caspase 7 and 3 activity. However, a significant difference in apoptotic rates induced by the three grape sources clearly emerged when treating cancer cells with low and intermediate GSE concentrations (25 and 50 mg/ml).

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confidence: 79%

Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2

Dinicola

Cucina²,

Pasqualato

et al. 2010

Br J Nutr

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“…In particular, Cavaliere et al demonstrated that the content of flavan-3-ols in grape seeds is influenced by several agronomic conditions mainly irrigation and nitrogen fertilization [11, 24]. …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-CandidaActivity ofVitis viniferaL. Seed Extracts Obtained from Wine and Table Cultivars

Simonetti

Santamaría

D’Auria

et al. 2014

BioMed Research International

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For the first time, grape seed extracts (GSEs), obtained from wine and table cultivars of Vitis vinifera L., cultured in experimental fields of Lazio and Puglia regions of Italy and grown in different agronomic conditions, have been tested on 43 Candida species strains. We demonstrated a significant correlation between the content of the flavan-3-ols in GSEs extracts, with a polymerization degree ≥4, and anti-Candida activity. Moreover, we demonstrated that GSEs, obtained from plants cultured with reduced irrigation, showed a content of polymeric flavan-3-ols >250 mg/g with geometric mean MIC values between 5.7 and 20.2 mg/L against Candida albicans reference strains. GSE, showing 573 mg/g of polymeric flavan-3-ols, has been tested in an experimental murine model of vaginal candidiasis by using noninvasive in vivo imaging technique. The results pointed out a significant inhibition of Candida albicans load 5 days after challenge. These findings indicate that GSEs with high content of polymeric flavan-3-ols can be used in mucosal infection as vaginal candidiasis.

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“…Furthermore, the accumulation of flavanols and PAs in seeds is dependent on variety [9,10,34,35]. Recent results showed that berry ripeness has an impact on the composition and extractability of seed tannins [36], and also that water deficit may affect the ripening process of berries [37,38].…”

Section: Resultsmentioning

confidence: 99%

Proanthocyanidin Accumulation and Biosynthesis Are Modulated by the Irrigation Regime in Tempranillo Seeds

Genebra

Santos

Francisco

et al. 2014

IJMS

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The main effects of three different irrigation regimes, i.e., sustained deficit irrigation (SDI), regulated deficit irrigation (RDI) and non-irrigated (NI), on seed traits namely proanthocyanidins (PAs) were evaluated in the wine grape cultivar Aragonez (syn. Tempranillo) grown in Alentejo (Portugal) over two growing seasons. Results showed that while the number of seeds per berry was not affected by water availability, seed fresh weight differed among treatments, the NI treatment exhibiting the lowest values. The biosynthetic pathway of flavanols appeared to be modified by the irrigation treatment, and several genes responsible for PA synthesis were up-regulated in the most stressed seeds (RDI and NI). However, this effect had no impact on PA content, suggesting the influence of other factors such as oxidation and/or degradation of PAs at late stages of maturation in grape seeds. The seeds’ non-enzymatic antioxidant capacities (oxygen radical absorbance capacity (ORAC) and hydroxyl radical adverting capacity (HORAC)) were modulated by water deficit and correlated well with PA content. The impact of irrigation strategy on PA biosynthesis, content, and anti-radical activity during seed ripening is discussed in the context of increasing interest in the role of PAs in the color and taste of wine, and the potential health benefits relating to their antioxidant capacity.

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The interactive effects of irrigation, nitrogen fertilisation rate, delayed harvest and storage on the polyphenol content in red grape (Vitis vinifera) berries: A factorial experimental design

Cited by 22 publications

References 18 publications

Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2

Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2

Evaluation of Anti-CandidaActivity ofVitis viniferaL. Seed Extracts Obtained from Wine and Table Cultivars

Proanthocyanidin Accumulation and Biosynthesis Are Modulated by the Irrigation Regime in Tempranillo Seeds

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