The innervation of the bladder and urethra1

Elliott, T. R.

doi:10.1113/jphysiol.1907.sp001198

Cited by 226 publications

(51 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In mammals the vesical nerve branches from the pelvic plexus join the bladder at the point where the ureters enter (Langley & Anderson, 1895;Elliot, 1907), and according to Gruber (1933) The results presented in this paper indicate that the contractions of the rat bladder, produced by electrical stimuli applied to the ureter, are due to excitation of nerves. The parameters of the stimuli are similar to those which excite autonomic nerve fibres to other organs.…”

Section: Discussionmentioning

confidence: 70%

Observations on an Isolated, Innervated Preparation of Rat Urinary Bladder

Huković

Rand

Vanov

1965

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 70%

Observations on an Isolated, Innervated Preparation of Rat Urinary Bladder

Huković

Rand

Vanov

1965

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

“…The responses to nicotine, DMPP and biogenic amines of the urinary bladder of mammals have been extensively studied (Langley & Anderson, 1895;Elliot 1907;Edmunds & Roth 1920;Henderson & Roepke 1935;Edge 1955;Gyermek 1961;Vanov 1965, Elmer 1974Creed 1979). Different sub-types of adrenoceptors on the wall of the urinary bladder exist but excitatory a-adrenoceptors (Edvardsen, 1968a;Tiara, 1972;Elmer, 1974;Creed, 1979) (Edvardsen 1968b;Edvardsen & Setekleiv 1968;de Groat, 1975, Hindmarsh etal., 1977Creed 1979).…”

Section: Discussionmentioning

confidence: 99%

The effects of nicotine on spontaneous contractions of cat urinary bladder in situ

Koley

Saha

1984

British J Pharmacology

View full text Add to dashboard Cite

1 Nicotine and dimethyl-phenylpiperazinium (DMPP) increased intravesicular pressure and then transiently depressed the spontaneous activity of the urinary bladder in chloralose anaesthetized cats.2 Adrenaline (5-10tgkg-1), noradrenaline (5-20pgkg-1) and isoprenaline (40-50 gkg-') which depressed spontaneous urinary bladder activity, were antagonized by the ,3-receptor blocking agent propranolol (1 mg kg-). Phenylephrine (10-30 jig kg-1) was ineffective on the urinary bladder though it increased the systemic blood pressure. This latter effect was blocked by the x-receptor blocking agent phentolamine (2 mg kg-1).3 Acetylcholine (2-8ytg kg-1) caused a marked fall in systemic blood pressure, which was potentiated by physostigmine, but failed to produce any response on the intravesicular pressure even after physostigmine (50-100 ig kg-') treatment.4 ATP (2 mg kg-) produced an increase in intravesicular pressure accompanied by a fall in systemic blood pressure. The increased intravesicular pressure was antagonized by quinidine (20 mg kg-'); however, the fall in blood pressure remained unaltered. (50-100pgkg-1) was not affected by phentolamine (2mgkg-1), propranolol (1 mgkg-') or guanethidine (15-20 mg kg-1). l lgkg-'), hemicholinium 3 (2 mgkg-1) or atropine (1 mgkg-') were also unable to affect the response to nicotine. 6 Hexamethonium (1 mg kg-'), reduced the amplitude of spontaneous bladder contractions and quinidine (20 mg kg-') abolished the effect of nicotine.

show abstract

“…Most studies on mammalian urinary bladder have been made using dogs or cats with the bladder in situ (Langley & Anderson, 1895;Elliot, 1907;Edmunds & Roth, 1920;Henderson & Roepke, 1935;Edge, 1955;Gyermek, 1961). Responses to drugs and to nerve stimulation have usually been recorded by measuring changes in the intravesical pressure.…”

Section: Discussionmentioning

confidence: 99%

“…In species other than the rat, contractions of the bladder have been observed on stimulation of the pelvic nerve, hypogastric nerve (see Gruber, 1933;Langley & Anderson, 1895;Elliot, 1907;Edge, 1955;Garret, 1963) and even the vagus nerves (Oehl, 1865, andPalumordwinov, 1916;cited in Gruber, 1933). The absence of responses of the bladder to stimulation of the vagus in the rat shows that in this species the vagus does not contribute motor fibres to the bladder.…”

Section: Discussionmentioning

confidence: 99%

“…Langley & Anderson (1895) first showed that stimulation of the pelvic nerves produced contraction of the bladder. Elliot (1907) reported considerable species differences in the innervation of the bladder. The responses of the urinary bladder of several mammalian species (dog, cat, rabbit and ring-tail possum) to drugs and to nerve stimulation have been investigated by Edmunds & Roth (1920), Henderson & Roepke (1935), Edge (1955), Ursillo & Clark (1956) and Burnstock & Campbell (1963).…”

mentioning

confidence: 99%

See 1 more Smart Citation

RESPONSES OF THE RAT URINARY BLADDER IN SITU TO DRUGS AND TO NERVE STIMULATION

Vanov

1965

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

The autonomic innervation of the urinary bladder has been studied extensively. Langley & Anderson (1895) first showed that stimulation of the pelvic nerves produced contraction of the bladder. Elliot (1907) reported considerable species differences in the innervation of the bladder. The responses of the urinary bladder of several mammalian species (dog, cat, rabbit and ring-tail possum) to drugs and to nerve stimulation have been investigated by Edmunds & Roth (1920), Henderson & Roepke (1935), Edge (1955), Ursillo & Clark (1956) and Burnstock & Campbell (1963).The present paper describes the actions of acetylcholine, nicotine, dimethylphenylpiperazinium and 5-hydroxytryptamine on the rat urinary bladder in situ. Responses of the bladder were elicited by stimulation of its motor nerves and compared with the responses produced by drugs. The results indicate that the autonomic innervation of the urinary bladder of the rat has characteristics of its own. METHODSRats of either sex weighing 180 to 250 g were used. They were anaesthetized by pouring a few drops of halothane on cotton wool in a Perspex box (dimensions 20 x 15 x 15 cm). Complete anaesthesia was obtained within 5 min. The rats were not atropinized because halothane, unlike ether, did not cause mucous secretion. A cannula was inserted into the trachea, the rats were pithed as described by Shipley & Tilden (1947) and immediately put on artificial ventilation. A polyethylene cannula was inserted into a femoral vein for injecting drugs. The blood pressure was recorded from a carotid artery with either a Condon manometer or a pressure transducer (Devices).The lower abdomen was opened along the midline, and the bladder exposed and detached from the prostate gland by blunt dissection. A thread attached to the vertex was fixed to a lever or to a straingauge for recording isotonic contractions, at a tension of 1.5 to 2 g, on a kymograph or a pen-recorder. Cotton-wool swabs soaked with warm saline were laid around the bladder to keep it warm and moist. The vesical nerves were stimulated by shielded platinum electrodes put underneath a ureter a few millimetres from the bladder. Rectangular pulses of 1 to 2 msec duration, and 5 to 10 V strength, generated from a Palmer electronic stimulator, were applied at a frequency of 10 or 20 shocks/sec, for 10 sec every 2 min.The hypogastric nerve was stimulated at about 1 cm from the bladder with pulses of 2 msec duration, 5 to 10 V strength and a frequency of 10 to 50 shocks/sec. In several experiments the right cervical vagus was stimulated. The stimuli applied were of the same duration, strength and frequency as those for the vesical nerves.The nerves were not cut, but stimulation was in effect only of centrifugal fibres, because the central nervous system in these animals had been destroyed by pithing.

show abstract

The innervation of the bladder and urethra1

Cited by 226 publications

References 0 publications

Observations on an Isolated, Innervated Preparation of Rat Urinary Bladder

Observations on an Isolated, Innervated Preparation of Rat Urinary Bladder

The effects of nicotine on spontaneous contractions of cat urinary bladder in situ

RESPONSES OF THE RAT URINARY BLADDER IN SITU TO DRUGS AND TO NERVE STIMULATION

Contact Info

Product

Resources

About