The initial distribution volume of glucose rather than indocyanine green derived plasma volume is correlated with cardiac output following major surgery

Ishihara, Hironori; Suzuki, Akiko; Okawa, Hirobumi; Sakai, Ichiro; Tsubo, Toshihito; Matsuki, Akitomo

doi:10.1007/s001340000653

Cited by 27 publications

(21 citation statements)

References 30 publications

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“…IDVG was correlated well with CO during and after subsequent fl uid volume loading in our experimental studies [1,2]. Additionally, IDVG rather than plasma volume, or blood volume, displays a better correlation with CO after major abdominal surgery, suggesting that IDVG has potential as an indicator of cardiac preload [10], even though glucose administered intravenously cannot stay in the intravascular compartment and is rapidly distributed into the extravascular space; thus, the concept of dilution volumetry is different from "true" cardiac preload.…”

Section: Discussionmentioning

confidence: 71%

Use of initial distribution volume of glucose to determine fluid volume loading in pulmonary thromboembolism and right ventricular myocardial infarction

et al. 2008

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We report a case of acute right ventricular myocardial infarction (right AMI) following pulmonary thromboembolism (PTE). Following percutaneous coronary intervention, the patient was treated in our intensive care unit (ICU) with intraortic balloon pumping, anticoagulants, and plasma expansion. Fluid overload may cause a further leftward shift of the interventricular septum in patients with PTE, resulting in decreased cardiac output (CO). The initial distribution volume of glucose (IDVG) has been reported to indicate central extracellular fluid volume. As both PTE and right AMI affect cardiac filling pressures, such as central venous pressure (CVP) and pulmonary artery wedge pressure (PAWP), we measured IDVG in order to evaluate the patient's cardiac preload, comparing it with the cardiac filling pressures. Fluid volume loading over 12 h yielded an obvious increase in IDVG. However, low arterial blood pressure and CO, associated with high CVP, remained unchanged and were accompanied by deteriorating pulmonary oxygenation. Accordingly, volume loading was discontinued and the rates of infusion of catecholamines were increased instead. At 12 h thereafter, IDVG became normal, and both CO and blood pressure became improved. However, the cardiac filling pressures remained increased. Although the patient died on the subsequent day, this case report could support the usefulness of IDVG as a fluid volume marker in critically ill patients, especially those with right AMI.

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Section: Discussionmentioning

confidence: 71%

Use of initial distribution volume of glucose to determine fluid volume loading in pulmonary thromboembolism and right ventricular myocardial infarction

et al. 2008

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“…The initial distribution volume of glucose (IDVG), representing central extracellular fluid (ECF) volume, is another tool for assessment of cardiac preload. Some studies indicated IDVG had closer correlation with cardiac output (CO) than plasma volume determined by the indocyanine green dilution method [2], and this method has been successfully used for prediction of postoperative hypovolemia [3,4].…”

Section: Introductionmentioning

confidence: 99%

Assessment of cardiac preload status by pulse pressure variation in patients after anesthesia induction: comparison with central venous pressure and initial distribution volume of glucose

Qiao

Zhou

et al. 2011

J Anesth

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“…We previously proposed initial distribution volume of glucose (IDVG), determined using injection of a small amount of glucose (5 g), as a measure of central extracellular fluid volume status [1-3]. Neither the plasma glucose values present before glucose injection nor infusion of insulin and/or vasoactive drugs had any apparent effect on IDVG calculation [1-3].…”

Section: Introductionmentioning

confidence: 99%

“…Neither the plasma glucose values present before glucose injection nor infusion of insulin and/or vasoactive drugs had any apparent effect on IDVG calculation [1-3]. IDVG has been demonstrated to correlate well with cardiac output in various critically ill conditions in the absence of congestive heart failure [1,4].…”

Section: Introductionmentioning

confidence: 99%

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et al. 2005

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Introduction We previously reported that initial distribution volume of glucose (IDVG) reflects central extracellular fluid volume, and that IDVG may represent an indirect measure of cardiac preload that is independent of the plasma glucose values present before glucose injection or infusion of insulin and/ or vasoactive drugs. The original IDVG measurement requires an accurate glucose analyzer and repeated arterial blood sampling over a period of 7 min after glucose injection. The purpose of the present study was to compare approximated IDVG, derived from just two blood samples, versus original IDVG, and to test whether approximated IDVG is an acceptable alternative measure of IDVG in the intensive care unit. Methods A total of 50 consecutive intensive care unit patients were included, and the first IDVG determination in each patient was analyzed. Glucose (5 g) was injected through the central venous line to calculate IDVG. Original IDVG was calculated using a one-compartment model from serial incremental arterial plasma glucose concentrations above preinjection using a reference glucose analyzer. Approximated IDVG was calculated from glucose concentrations in both plasma and whole blood, using a combined blood gas and glucose analyzer, drawn at two time points: immediately before glucose injection and 3 min after injection. Subsequently, each approximated IDVG was calculated using a formula we proposed previously. Results The difference (mean ± standard deviation) between approximated IDVG calculated from plasma samples and original IDVG was -0.05 ± 0.54 l, and the difference between approximated IDVG calculated from whole blood samples and original IDVG was -0.04 ± 0.61 l. There was a linear correlation between approximated and original IDVG (r 2 = 0.92 for plasma samples, and r 2 = 0.89 for whole blood samples). Conclusion Our findings demonstrate that there was good correlation between each approximated IDVG and original IDVG, although the two measures are not interchangeable. This suggests that approximated IDVG is clinically acceptable as an alternative calculation of IDVG, although approximated and original IDVGs are not equivalent; plasma rather than whole blood measurements are preferable.

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The initial distribution volume of glucose rather than indocyanine green derived plasma volume is correlated with cardiac output following major surgery

Abstract: Our results indicate that IDVG rather than intravascular volume is correlated with cardiac output. We suggest that IDVG has potential as an alternative indicator of cardiac preload following major surgery.

Cited by 27 publications

References 30 publications

Use of initial distribution volume of glucose to determine fluid volume loading in pulmonary thromboembolism and right ventricular myocardial infarction

Use of initial distribution volume of glucose to determine fluid volume loading in pulmonary thromboembolism and right ventricular myocardial infarction

Assessment of cardiac preload status by pulse pressure variation in patients after anesthesia induction: comparison with central venous pressure and initial distribution volume of glucose

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