The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain

Santos, D.; Milatović, Dejan; Andrade, Vanda; Batoréu, M.C.; Aschner, Michael; Santos, A.P. Marreilha dos

doi:10.1016/j.tox.2011.11.017

Cited by 99 publications

(62 citation statements)

References 84 publications

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“…At high substrate concentrations, it probably is displaced from α-site to only occupy the β-site, therefore causing activation [22]. , the results here corroborate other works [25,26]. Al 3+ didn't appear among the groups of ions reported by…”

Section: Discussionsupporting

confidence: 91%

Effect of ions on the activity of brain acetylcholinesterase from tropical fish

Assis¹,

Linhares²,

Oliveira³

et al. 2015

J Coast Life Med

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Section: Discussionsupporting

confidence: 91%

Effect of ions on the activity of brain acetylcholinesterase from tropical fish

Assis¹,

Linhares²,

Oliveira³

et al. 2015

J Coast Life Med

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“…Although the concentration of Cd was below the established level set by the Brazilian legislation, Cd is a human carcinogen, a potent endocrine disruptor, and exerts toxic effects on kidney, skeletal, respiratory, and reproductive systems (Gerbron et al 2015;Jiménez-Ortega et al 2012;Wang et al 2014;WHO 2011). Mn and Pb can inhibit AchE (Santos et al 2012), and mixtures of Pb + Cd (detected in SC) can induce neuronal degeneration in the brain even at low concentrations (Cobbina et al 2015).…”

Section: Physicochemical Parameters Are Not Enough To Predict the Chementioning

confidence: 99%

Bioavailability of pollutants sets risk of exposure to biota and human population in reservoirs from Iguaçu River (Southern Brazil)

Yamamoto

Pereira

Lottermann

et al. 2016

Environ Sci Pollut Res

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The Iguaçu River, located at the Southern part of Brazil, has a great socioeconomic and environmental importance due to its high endemic fish fauna and its potential to generate hydroelectric power. However, Iguaçu River suffers intense discharge of pollutants in the origin of the river. In a previous report, the local environmental agency described water quality to improve along the river course. However, no study with integrated evaluation of chemical analysis and biological responses has been reported so far for the Iguaçu River. In the current study, three different Brazilian fish species (Astyanax bifasciatus, Chrenicicla iguassuensis, and Geophagus brasiliensis) were captured in the five cascading reservoirs of Iguaçu River for a multi-biomarker study. Chemical analysis in water, sediment, and muscle indicated high levels of bioavailable metals in all reservoirs. Polycyclic aromatic hydrocarbons (PAHs) were detected in the bile of the three fish species. Integration of the data through a FA/PCA analysis demonstrated the poorest environmental quality of the reservoir farthest from river's source, which is the opposite of what has been reported by the environmental agency. The presence of hazardous chemicals in the five reservoirs of Iguaçu River, their bioaccumulation in the muscle of fish, and the biological responses showed the impacts of human activities to this area and did not confirm a gradient of pollution between the five reservoirs, from the source toward Iguaçu River's mouth. Therefore, diffuse source of pollutants present along the river course are increasing the risk of exposure to biota and human populations.

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“…Similar conflicting results were found in the effect of Mn on AChE. In studies that used prolonged Mn exposure, Mn caused a reduction in AChE activity [129,137,138]. On the other hand, high sub-acute Mn doses resulted in elevations in AChE activity [128,139,140].…”

Section: Mn Toxicitymentioning

confidence: 88%

“…Santos et al found a dose-dependent increase prostaglandin and isoprostanes post MnCl2 injections in rats [129]. Also, Fernsebner et al…”

Section: Introductionmentioning

confidence: 93%

“…In another study by Santos et al, high doses of MnCl2 were intraperitoneally injected into rats and caused a significant reduction in acetylcholinesterase (AChE) activity [129]. In the same study, they found protein levels of Mn-SOD were significantly increased, as well as brain levels of prostaglandin 2 (PGE2) and F2-isoprostane (F2-IsoPs), which are produced as a result of the generation of reactive oxygen species [129]. Milatovic et al…”

Section: Mn Toxicitymentioning

confidence: 99%

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Effect of hemochromatosis on manganese neurotoxicity

Alsulimani¹

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ABSTRACT:Manganese (Mn) is an essential element for normal brain function, but excess levels of Mn in the brain are associated with a number of behavioral problems, including motor dysfunction, memory loss and psychiatric disorders. While Mn is known to share iron transporters for cellular uptake, deficiency in the Hfe (hemochromatosis), a cellular iron regulatory protein, affects the activities of iron transporters and impairs iron metabolism. Previously it was shown that Mn uptake into the brain is increased after intranasal exposure to Mn in Hfe-deficient mice, a mouse model of iron overload hereditary hemochromatosis. However, there is limited information about the effect of Hfe deficiency on Mn toxicity after exposure by other routes. Mn exposure is common through ingestion and inhalation in both environmental and occupational settings. Because Hfe deficiency alters iron transporters, and since Mn shares iron transporters, I hypothesize that Hfe deficiency increases Mn toxicity by modulating Mn uptake from the absorption site and deposition into the target organ for Mn toxicity which is the brain after gastric exposure in drinking water and pulmonary exposure to Mn particles. Specific aims are focused on the effect of Hfe deficiency on 1) the expression levels of metal transporters in the brain, gut and lung including alveolar macrophages, 2) levels of Mn, 3) Mn-associated neurobehavioral impairments, and 4) mechanisms of Mn neurotoxicity. This research will enhance the knowledge of Mn exposure and uptake in Hfe-related hemochromatosis, a prevalent iron disorder in the world.

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The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain

Cited by 99 publications

References 84 publications

Effect of ions on the activity of brain acetylcholinesterase from tropical fish

Effect of ions on the activity of brain acetylcholinesterase from tropical fish

Bioavailability of pollutants sets risk of exposure to biota and human population in reservoirs from Iguaçu River (Southern Brazil)

Effect of hemochromatosis on manganese neurotoxicity

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