The inhibition of salivary secretion by histamine H2-antagonists—a study on the cat submandibular gland

Abstract

The aim of the present work was to establish whether the secretory process can be influenced by histamine H2-receptor antagonists, burimamide and metiamide. These drugs were applied intravenously and the secretion was evoked by the electrical stimulation of the chorda tympani nerve or by carbachol (i.v.). In addition to the measurements of the flow of saliva, the blood flow through the gland was measured in some experiments. Both H2-antagonists significantly reduced the rate of salivary secretion induced by the chorda tympani stimulation. The experiments with burimamide did not permit the calculation of dose-response relationship. From the experiments with metiamide the ED50 was 4.6 mumols/kg and Emax was 30% reduction of secretion. The secretory response to carbachol was not diminished by burimamide. In addition to the effect of metiamide on salivation, the reduction of the blood flow through the gland was observed: the effect on the blood flow was significantly smaller, and slower in onset, than the effect on salivation. These results support the hypothesis that H2-receptors are involved in the process of salivary secretion. Histamine effects on glandular elements seem to be more significant than its effect on the blood vessels.

The role of tissue mast cells in exocrine secretion: Studies in the submandibular gland of the cat

“…As is shown in the present work, histamine injected intra-arteriaUy into the gland increases salivation which is induced by carbachol infusion. We have shown in the experiments with histamine H2-antagonists, burimamide and cimetidine, that both drugs inhibit salivation of the cat submandibular gland if it is stimulated by the chorda tympani nerve [24]. The histamine H 2-receptors antagonists seem to inhibit histamine effects on the secretory and thereafter on the vascular apparatus of the organ.…”

Histamine H1 Receptor Induces Cytosolic Calcium Increase and Aquaporin Translocation in Human Salivary Gland Cells

“…In rat parotid tissues, histamine is reported to stimulate H2 receptors and induce amylase secretion (Eguchi et al, 1998). Salivary secretion in cats and rats is inhibited by histamine H2 receptor antagonists (Stanovnik and Erjavec, 1983;Sim and Ang, 1985). Adenylyl cyclase-linked G protein-coupled receptor activation serves an important role in salivary protein secretion via intracellular cAMP production (Yamada et al, 2006).…”

Histamine prevents functional and morphological alterations of submandibular glands induced by ionising radiation

“…It was previously reported that histamine could act as a stimulator of salivary secretion in submandibular gland (SMG) of cats and dogs (Shimizu andTaira 1980, Stanovnik andErjavec 1983). Furthermore, histamine treatment induces the translocation of aquaporin-5, which modulates water secretion to produce primary saliva, to the plasma membrane in human SMG cells (Kim et al 2009).…”