The influence of the TNFα rs1800629 polymorphism on some inflammatory biomarkers in 45-60-year-old women with metabolic syndrome

Szkup, Małgorzata; Chełmecka, Elżbieta; Lubkowska, Anna; Owczarek, Aleksander; Grochans, Elżbieta

doi:10.18632/aging.101600

Cited by 11 publications

(42 citation statements)

References 37 publications

(42 reference statements)

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“…The minimum sample size was estimated at 52 sample elements for a type I error margin of 1%, study power of 80%, and large effect size of 0.80 [48] for comparing means between independent groups.…”

Section: Type Of Study and Included Patientsmentioning

confidence: 99%

Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women

Sinatora

Chagas

Mattera³

et al. 2022

Metabolites

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The increased deposition of visceral fat in the postmenopause period increases the production of inflammatory cytokines and the release of tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), and decrease in IL-10. This study investigated the relationship between inflammatory biomarkers and metabolic syndrome (MS) in postmenopausal women considering different diagnostic criteria. We conducted a cross-sectional observational study based on STROBE. Data were collected regarding the diagnostic criteria for MS (International Diabetes Federation; NCEP (International Diabetes Federation (IDF), National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III), and Harmonized criteria), body composition, comorbidities, time without menstruation, values of IL-6, IL-10, and TNF-α. ANOVA, Kruskal–Wallis, Levene tests, ROC, and odds ratio were performed to analyze the data. The results showed no significant difference between the methods and no interaction between the method and the presence of MS. However, for the values of WC, body fat percentage, TNF-α, and IL-10/TNF-α ratio, a significant effect of MS was observed. In subjects with MS, lower values of body fat percentage and TNF-α and higher values of the IL-10/TNF-α ratio were also observed. The higher IL-10/TNF-α ratio in the MS group is related to the greater anti-inflationary action of IL-10. The IL-10/TNF-α ratio showed significant accuracy to discriminate patients with MS according to the NCEP-ATP III criteria.

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Section: Type Of Study and Included Patientsmentioning

confidence: 99%

Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women

Sinatora

Chagas

Mattera³

et al. 2022

Metabolites

View full text Add to dashboard Buy / Rent full text

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“…Nevertheless, the results are still rather inconsistent. We have reviewed a number of studies reporting the levels of TNF-α in different populations of mixed adults across the different genotypes for some of those variants, predominantly for the −308 G/A [ 41 , 42 , 137 , 139 , 140 , 141 , 142 , 143 , 144 ] ( Table S7 ). As repeatedly indicated in the previous sections, we found a very high intra-subgroup (genotype) variability with most CV% values well above 30% and in many cases >100%.…”

Section: The Influence Of Genetic Variants On Tnf-α Levelsmentioning

confidence: 99%

An Exploratory Critical Review on TNF-α as a Potential Inflammatory Biomarker Responsive to Dietary Intervention with Bioactive Foods and Derived Products

Quarta

Massaro²,

Carluccio³

et al. 2022

Foods

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This review collects and critically examines data on the levels of tumour necrosis factor-alpha (TNF-α) in lean, overweight and obese subjects, and the effects of intervention with different foods and food products containing bioactive constituents in overweight/obese individuals. We additionally explore the influence of different single nucleotide polymorphisms (SNPs) on TNF-α levels and compare the response to food products with that to some anti-obesity drugs. Our aim was to provide an overview of the variability, consistency, and magnitude of the reported effects of dietary factors on TNF-α, and to envisage the reliability of measuring changes in the levels of this cytokine as a biomarker responsive to food intervention in association with the reduction in body weight. Regarding the circulating levels of TNF-α, we report: (i) a large intra-group variability, with most coefficients of variation (CV%) values being ³30% and, in many cases, >100%; (ii) a large between-studies variability, with baseline TNF-α values ranging from <1.0 up to several hundred pg/mL; (iii) highly variable effects of the different dietary approaches with both statistically significant and not significant decreases or increases of the protein, and the absolute effect size varying from <0.1 pg/mL up to ≈50 pg/mL. Within this scenario of variability, it was not possible to discern clear differentiating limits in TNF-α between lean, overweight, and obese individuals or a distinct downregulatory effect on this cytokine by any of the different dietary approaches reviewed, i.e., polyunsaturated fatty acids (PUFAs), Vitamin-D (VitD), mixed (micro)nutrients, (poly)phenols or other phytochemicals. Further, there was not a clear relationship between the TNF-α responses and body weight changes. We found similarities between dietary and pharmacological treatments in terms of variability and limited evidence of the TNF-α response. Different factors that contribute to this variability are discussed and some specific recommendations are proposed to reinforce the need to improve future studies looking at this cytokine as a potential biomarker of response to dietary approaches.

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“…In line with these recent data, and for validating the associations previously observed [22], here, we aimed to investigate the potential association of functional polymorphisms in IL-6, IL-1A, IL-1B, IL-18, and Tumor necrosis factor (TNF)A genes with TAAA susceptibility, pathogenesis, and outcome, in 144 patients affected by sporadic TAAA and 150 age/gender matched controls. Five functional promoter polymorphisms in the genes encoding for IL-6, IL-1α, IL-1β, IL-18 and TNF-α pro-inflammatory cytokines, known to be functionally important, because they influence both the transcription rate of the related genes and cytokine plasma concentrations, have been selected [26][27][28][29][30]. In addition, we evaluated the eventual genotypes of these gene variants able to influence in a significant manner the systemic levels of the analyzed cytokines and other inflammatory markers (i.e., proteases), as well as the amounts of tissue infiltrated CD3+CD4+CD8+CD68+CD20+ immune/inflammatory cells.…”

Section: Figurementioning

confidence: 99%

Polymorphisms of Pro-Inflammatory IL-6 and IL-1β Cytokines in Ascending Aortic Aneurysms as Genetic Modifiers and Predictive and Prognostic Biomarkers

et al. 2021

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Background: Previous studies have demonstrated that polymorphisms involved in immune genes can affect the risk, pathogenesis, and outcome of thoracic ascending aortic aneurysms (TAAA). Here, we explored the potential associations of five functional promoter polymorphisms in interleukin-6 (IL-6), IL-1B, IL-1A, IL-18, and Tumor necrosis factor (TNF)A genes with TAAA. Methods: 144 TAAA patients and 150 age/gender matched controls were typed using KASPar assays. Effects on telomere length and levels of TAAA related histopathological and serological markers were analyzed. Results: Significant associations with TAAA risk were obtained for IL-6 rs1800795G>C and IL-1B rs16944C>T SNPs. In addition, the combined rs1800795C/rs16944T genotype showed a synergic effect on TAAA pathogenesis and outcome. The combined rs1800795C/rs16944T genotype was significantly associated with: (a) higher serum levels of both cytokines and MMP-9 and -2; (b) a significant CD3+CD4+CD8+ CD68+CD20+ cell infiltration in aorta aneurysm tissues; (c) a significant shorter telomere length and alterations in telomerase activity. Finally, it significantly correlated with TAAA aorta tissue alterations, including elastic fragmentation, medial cell apoptosis, cystic medial changes, and MMP-9 levels. Conclusions: the combined rs1800795C/rs16944T genotype appears to modulate TAAA risk, pathogenesis, and outcome, and consequently can represent a potential predictive and prognostic TAAA biomarker for individual management, implementation of innovative treatments, and selection of the more proper surgical timing and approaches.

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The influence of the TNFα rs1800629 polymorphism on some inflammatory biomarkers in 45-60-year-old women with metabolic syndrome

Cited by 11 publications

References 37 publications

Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women

Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women

An Exploratory Critical Review on TNF-α as a Potential Inflammatory Biomarker Responsive to Dietary Intervention with Bioactive Foods and Derived Products

Polymorphisms of Pro-Inflammatory IL-6 and IL-1β Cytokines in Ascending Aortic Aneurysms as Genetic Modifiers and Predictive and Prognostic Biomarkers

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