The influence of the neurohumor serotonin on hibernation in the golden-mantled ground squirrel, Citellus lateralis

Induction of Unseasonable Hibernation and Involvement of Serotonin in Entrance into and Maintenance of Its Hibernation of Chipmunks T. asiaticus.

“…Saline-treated controls did not enter into hibernation within 3 weeks after the infusion began. These results support the finding of Spafford and Pengelley [25] that brain 5-HT decreases during entrance into hibernation compared with the euthermia 5-HT level in ground squirrel. Both findings suggest that reduced 5-HT is an important trigger for entrance into hibernation in chipmunks.…”

Induction of Unseasonable Hibernation and Involvement of Serotonin in Entrance into and Maintenance of Its Hibernation of Chipmunks T. asiaticus.

“…Saline-treated controls did not enter into hibernation within 3 weeks after the infusion began. These results support the finding of Spafford and Pengelley [25] that brain 5-HT decreases during entrance into hibernation compared with the euthermia 5-HT level in ground squirrel. Both findings suggest that reduced 5-HT is an important trigger for entrance into hibernation in chipmunks.…”

The brain 5‐HT1A receptor gene expression in hibernation

“…The data suggested that brain 5‐HT was involved as an inhibitory factor in the control of hibernation. This hypothesis was confirmed by the experiments showing that the decrease in brain 5‐HT level as a result of midbrain raphe nuclei lesion or pretreatment with inhibitor of 5‐HT biosynthesis p ‐CPA evoked the arousal from hibernation (Popova et al 1978; Spafford & Pengelley 1971), whereas 5‐HT precursor 5‐hydroxytryptophan administered into brain ventricle III prolonged the time taken for arousal (Popova & Kudryavtseva 1985).…”

Modification of Glial Response in Hibernation

“…Research performed on hibernating squirrels has pointed to the involvement of 5-HT in the entrance and maintenance of the hibernation state (Spafford and Pengelley, 1971; Haak et al, 1991; Popova et al, 1993). Similarly, previous data obtained in snails has also indicated that 5-HT is involved in the maintenance of the hibernation state, as an elevated level of 5-HT was detected in the brain for almost the whole period of hibernation (Michaelidis et al, 2002).…”

Induction of Unseasonable Hibernation and Involvement of Serotonin in Entrance into and Maintenance of Its Hibernation of Chipmunks T. asiaticus.

“…Saline-treated controls did not enter into hibernation within 3 weeks after the infusion began. These results support the finding of Spafford and Pengelley [25] that brain 5-HT decreases during entrance into hibernation compared with the euthermia 5-HT level in ground squirrel. Both findings suggest that reduced 5-HT is an important trigger for entrance into hibernation in chipmunks.…”

The brain 5‐HT1A receptor gene expression in hibernation

“…The data suggested that brain 5‐HT was involved as an inhibitory factor in the control of hibernation. This hypothesis was confirmed by the experiments showing that the decrease in brain 5‐HT level as a result of midbrain raphe nuclei lesion or pretreatment with inhibitor of 5‐HT biosynthesis p ‐CPA evoked the arousal from hibernation (Popova et al 1978; Spafford & Pengelley 1971), whereas 5‐HT precursor 5‐hydroxytryptophan administered into brain ventricle III prolonged the time taken for arousal (Popova & Kudryavtseva 1985).…”

Modification of Glial Response in Hibernation

“…Research performed on hibernating squirrels has pointed to the involvement of 5-HT in the entrance and maintenance of the hibernation state (Spafford and Pengelley, 1971; Haak et al, 1991; Popova et al, 1993). Similarly, previous data obtained in snails has also indicated that 5-HT is involved in the maintenance of the hibernation state, as an elevated level of 5-HT was detected in the brain for almost the whole period of hibernation (Michaelidis et al, 2002).…”

Induction of Unseasonable Hibernation and Involvement of Serotonin in Entrance into and Maintenance of Its Hibernation of Chipmunks T. asiaticus.

“…Saline-treated controls did not enter into hibernation within 3 weeks after the infusion began. These results support the finding of Spafford and Pengelley [25] that brain 5-HT decreases during entrance into hibernation compared with the euthermia 5-HT level in ground squirrel. Both findings suggest that reduced 5-HT is an important trigger for entrance into hibernation in chipmunks.…”

The brain 5‐HT1A receptor gene expression in hibernation

“…The data suggested that brain 5‐HT was involved as an inhibitory factor in the control of hibernation. This hypothesis was confirmed by the experiments showing that the decrease in brain 5‐HT level as a result of midbrain raphe nuclei lesion or pretreatment with inhibitor of 5‐HT biosynthesis p ‐CPA evoked the arousal from hibernation (Popova et al 1978; Spafford & Pengelley 1971), whereas 5‐HT precursor 5‐hydroxytryptophan administered into brain ventricle III prolonged the time taken for arousal (Popova & Kudryavtseva 1985).…”

Modification of Glial Response in Hibernation

“…Research performed on hibernating squirrels has pointed to the involvement of 5-HT in the entrance and maintenance of the hibernation state (Spafford and Pengelley, 1971; Haak et al, 1991; Popova et al, 1993). Similarly, previous data obtained in snails has also indicated that 5-HT is involved in the maintenance of the hibernation state, as an elevated level of 5-HT was detected in the brain for almost the whole period of hibernation (Michaelidis et al, 2002).…”