2001
DOI: 10.1055/s-2001-14292 View full text |Buy / Rent full text
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Abstract: The duration of CPB affects thrombin formation as well as platelet count and function, but not the fibrinolytic system. This may prove to be a disadvantage when employing minimally invasive techniques that prolong the duration of CPB.

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“…Correlations have been described between the need for PC transfusion and the body surface area of the patient or the CPB time [18], and between platelet count in the patient after surgery and CPB time [19]. We were unable to confirm the latter, and we did not observe a correlation between the volume of thorax drain fluid and body surface area or CPB time.…”
Section: Discussioncontrasting
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“…Correlations have been described between the need for PC transfusion and the body surface area of the patient or the CPB time [18], and between platelet count in the patient after surgery and CPB time [19]. We were unable to confirm the latter, and we did not observe a correlation between the volume of thorax drain fluid and body surface area or CPB time.…”
Section: Discussioncontrasting
“…(Williams et al 2011) described CPB time as an independent predictor of massive transfusion (per 10 min increase: odds ratio 1·15). Likewise other investigators could demonstrate a relationship between duration of CPB and coagulopathies (Wahba et al, 2001;Greilich et al, 2002), but as far as we know no cut-off time has yet been issued, beyond which the coagulation capacity declines in an exponential manner. Thus, we chose CPB time >100 min as inclusion criteria.…”
Section: Discussionmentioning
“…The ideal CPB time to prevent coagulopathy and severe PLT dysfunction is unknown. Certainly, prolonged runs on CPB are known to cause coagulopathy . The mean CPB time was 137 minutes, which could be shortened for less complex surgeries.…”
Section: Discussionmentioning
“…Certainly, prolonged runs on CPB are known to cause coagulopathy. 26 The mean CPB time was 137 minutes, which could be shortened for less complex surgeries. Additionally, there are little data on the degree of hypothermia that should be used to balance organ protection with coagulopathy.…”
Section: Discussionmentioning