The influence of the delta-sleep-inducing peptide on convulsive activity

Abstract

Data are presented in this paper on the influence of the delta-sleep-inducing peptide (DSIP) on various forms of convulsive activity. The capacity of this peptide to suppress convulsive activity in foci created in the cerebral cortex by the application of strychnine has been demonstrated in experiments on cats. It has been established in experiments on rats that DSIP determines the later development of the convulsive kindling syndrome, and prevents the development of convulsions in mice induced by bicuculline, picrotoxin, and corazol, but is devoid of such action in relation to thiosemicarbazide and strychnine. It was demonstrated that the anticonvulsant action of DSIP is associated with its influence on the reticular portion of the substantia nigra. The lowest level of this peptide itself has been discovered, in the reticular portion of the substantia nigra at the late stages of pharmacological kindling. It is inferred that DSIP may represent one of the factors of the endogenous control of the excitability of the brain.

Cytochemical and morphological changes in cerebral neurons induced by δ-sleep peptide

“…Based on A. A. Ukhtomskii's theory on the dominant, according to which cortical zones containing large pyramidal 1.14 (10) neurons and the possibility of formation in these structures of stable stimulation with the dominant properties are significant [7], we believe that a decrease in protein production and cell size induced by DSP are cytochemical and morphological manifestations of inhibition in a focus of stimulation formed under the effect of prolonged administration of L-DOPA.…”

“…Stress-protective and regulating effects of 5-sleep peptide (DSP) have been extensively studied in various diseases [3][4][5][6]10,11] during the last two decades [13]; however, metabolism modifications and restructuring in the brain caused by this peptide are still little known.…”

Interaction of Delta Sleep-inducing Peptide and Valproate on Metaphit Audiogenic Seizure Model in Rats

“…DSIP, an endogenous anticonvulsive substance, is constantly present in different brain regions, especially in the limbic structure, and can inhibit a number of the effects of excitatory amino acids , preventing occurrences of the excitatory effect of the glutamate via NMDA-receptors and blocks calcium influx, in other words stopped excitotoxicity (Umriuhkin 2002;Sudakov et al 2004). Russian neuroscientists described DSIP antiepileptic activity on bicuculine, corasol, picrotoxin, and benzylpenicillin sodium (all are associated with gamma-aminobutyric acid) induced epilepsy (Prudchenko et al 1993;Shandra et al 1993Shandra et al , 1998Mikhaleva et al 1992;Mendzheritskii et al 1997). Taken together with the facts that DSIP after i.p.…”

“…This nonapeptide, member of the natural sleep peptide family, has attracted attention in recent years as an endogenous modulator of epileptic activity. Due to its antiepileptic action in several acute generalized epilepsy forms (Prudchenko et al 1993;Shandra et al 1993Shandra et al , 1998, this natural peptide arose as a special interest of our research.…”

Homocysteine: Neurotoxicity and mechanisms of induced hyperexcitability

“…Furthermore, experimental models of epilepsy may be induced by manipulations of γ-aminobuturic acid (e.g., bicuculline, corasol, picrotoxin and benzylpenicillin sodium) (30). In contrast, epilepsy can be induced by an opposite mechanism such as by increasing cerebral excitatory neurotransmission.…”