The influence of radiotherapy on ceruloplasmin and transferrin in whole blood of breast cancer patients

Krzyminiewski, Ryszard; Dobosz, Bernadeta; Kubiak, Tomasz

doi:10.1007/s00411-017-0708-3

Cited by 14 publications

(9 citation statements)

References 23 publications

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“…Ceruloplasmin levels were corelated with tumor burden (10). A recent study showed that ceruloplasmin and transferine are increased in patients with breast cancer after radiotherapy (19). The extension of the degradation of proteins is at a much less scale, and it takes time to be activated so the thiols were not so elevated.…”

Section: Discussionmentioning

confidence: 99%

Tumor is an Oxidative Stress Factor in Ovarian Cancer Patients

Trifănescu¹,

Gruia²,

Galeş³

et al. 2018

chr

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Introducere: Adenocarcinomul ovarian reprezintă la nivel global, a doua cauză de neoplazie în rândul tumorilor ginecologice, dar este principala cauză de mortalitate prin tumori ginecologice. Scopul acestui studiu a fost să identifice intensitatea stresului oxidative la pacienţii cu adenocarcinom ovarian şi să identifice relaţiile dintre diferite specii reactive de oxigen (ROS) şi prezenţa tumorii reziduale. Pacienţi şi metode: Treizeci-şi-cinci paciente cu adenocarcinom ovarian stadiul II-IV, diagnosticate între 2010-2017, care au primit tratament multimodal constând în intervenţie chirurgicală şi chimioterapie pe baza de săruri de platină au fost incluse în studiu. ROS măsurate în dinamică (4 determinări înaintea fiecărui ciclu de chimioterapie) au fost malondialdehida pentru evaluarea peroxidării lipidice, cerulosplamina, grupările tiol şi antioxidanţii totali. Rezultate: S-a înregistrat o creştere sistematică a valorilor ROS: valorile medii ale malondialdehidei au fost de 8.1 μmol/ 100 ml (valorile normale sub 4 μmol/100ml); valoarea media a ceruloplasminei a fost de 144.8 U.I. (normal 120U.I). Ambele valori crescute arată că tumora induce un important proces oxidativ. Valorile tiolilor au fost puţin scăzute faţă de valorile normale (395 vs. 450 μmol/l). S-a constat o uşoară creştere a valorilor antioxidanţilor totali (1.44 vs 1.4 μmol). Toţi aceşti patru compuşi au scăzut între prima şi a patra determinare. S-a înregistrat o corelaţie puternică între malondialdehida şi ceruloplasmină (coeficient Pearson 0.315 p=0.005) şi între peroxidarea lipidică şi grupările tiolice (coeficient Pearson 0.23 p=0.039), precum şi între grupările tiolice şi antioxidanţi (coeficient Pearson 0.33 p=0.003). Peroxidarea lipidică şi

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Section: Discussionmentioning

confidence: 99%

Tumor is an Oxidative Stress Factor in Ovarian Cancer Patients

Trifănescu¹,

Gruia²,

Galeş³

et al. 2018

chr

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“…Intracellular iron export is mediated by ferroportin (FPN) [ 65 ]. FPN exports Fe 2+ to the extracellular space where it is oxidized by ceruloplasmin (CP) [ 66 ], hephaestin (HEPH) [ 67 ], and zyklopen (HEPHL1) [ 66 ]. FPN is expressed in numerous cell types, in particular, in those involved in the regulation of plasma iron levels, such as enterocytes, macrophages, and hepatocytes [ 68 ].…”

Section: Intracellular Iron Metabolismmentioning

confidence: 99%

Iron Metabolism in the Tumor Microenvironment—Implications for Anti-Cancer Immune Response

Sacco

Battaglia

Botta

et al. 2021

Cells

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New insights into the field of iron metabolism within the tumor microenvironment have been uncovered in recent years. Iron promotes the production of reactive oxygen species, which may either trigger ferroptosis cell death or contribute to malignant transformation. Once transformed, cancer cells divert tumor-infiltrating immune cells to satisfy their iron demand, thus affecting the tumor immunosurveillance. In this review, we highlight how the bioavailability of this metal shapes complex metabolic pathways within the tumor microenvironment and how this affects both tumor-associated macrophages and tumor-infiltrating lymphocytes functions. Furthermore, we discuss the potentials as well as the current clinical controversies surrounding the use of iron metabolism as a target for new anticancer treatments in two opposed conditions: (i) the “hot” tumors, which are usually enriched in immune cells infiltration and are extremely rich in iron availability within the microenvironment, and (ii) the “cold” tumors, which are often very poor in immune cells, mainly due to immune exclusion.

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“…Ceruloplasmin loss-of-function is involved in neurodegenerative syndrome, whereas high ceruloplasmin level is associated with copper toxicity, Alzheimer's disease and cardiovascular diseases 43,44 . As ceruloplasmin levels were significantly high in cancer, ceruloplasmin has been suggested to be potential biomarkers in numerous solid tumors [45][46][47][48][49][50] . The relationship between ceruloplasmin level and bladder cancer has not been documented previously.…”

Section: Healthy Controls Lg Tumoursmentioning

confidence: 99%

Circulating proteomic signature for detection of biomarkers in bladder cancer patients

Nedjadi

Benabdelkamal

Albarakati

et al. 2020

Sci Rep

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The identification of clinically-relevant early diagnostic and prognostic protein biomarkers is essential to maximize therapeutic efficacy and prevent cancer progression. The aim of the current study is to determine whether aberrant plasma protein profile can be applied as a surrogate tool for early diagnosis of bladder carcinoma. Plasma samples from patients with low grade non-muscle invasive bladder cancer and healthy controls were analyzed using combined 2D-DIGE and mass-spectrometry to identify differentially expressed proteins. Validation was performed using western blotting analysis in an independent cohort of cancer patients and controls. Fifteen differentially-expressed proteins were identified of which 12 were significantly up-regulated and three were significantly down-regulated in tumors compared to controls. The Ingenuity Pathways Analysis revealed functional connection between the differentially-expressed proteins and immunological disease, inflammatory disease and cancer mediated through chemokine and cytokine signaling pathway and NF-kB transcription factor. Among the three validated proteins, haptoglobin was able to distinguish between patients with low grade bladder cancer and the controls with high sensitivity and specificity (AUC > 0.87). In conclusion, several biomarker proteins were identified in bladder cancer. Haptoglobin is a potential candidate that merit further investigation to validate its usefulness and functional significance as potential biomarkers for early detection of bladder cancer. Bladder carcinoma (BC) is the second most common cancer of the genitourinary tract and a leading cause of mortality worldwide. According to a recent data, an estimated 450,000 persons developed BC and more than 199,000 persons died of BC in the year 2018 1. Early diagnosis of bladder cancer has a better prognosis with a 10-year disease-free survival of 86% for non-muscle invasive bladder cancer (NMIBC) (stage T0). However, due to the absence of reliable prognostic markers, recurrence rates fluctuate between 30 and 70% with as high as 10-30% rates of progression to muscle-invasive bladder cancer (MIBC) phenotype for high-risk patients 2,3. This situation necessitates vigilant management protocol through frequent cystoscopy/cytology examinations and different treatment modalities. The extended treatment and long-term follow-up make bladder cancer treatment one of the most expensive per patient among all cancers 4. Therefore, biomarkers for early stage screening of non-muscle invasive bladder cancer is desperately needed as it will help in early diagnosis, preventing disease progression to a life-threatening phenotype (MIBC) and will eventually lower the associated costs of treatment. Furthermore, early diagnosis of bladder cancer would be of great importance in discerning patients with high grade cancer from those with low grade cancer and in selecting the appropriate therapeutic approaches. Despite development and FDA-approval of several urine and blood-based biomarker kits for appraisal of bladder ca...

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The influence of radiotherapy on ceruloplasmin and transferrin in whole blood of breast cancer patients

Cited by 14 publications

References 23 publications

Tumor is an Oxidative Stress Factor in Ovarian Cancer Patients

Tumor is an Oxidative Stress Factor in Ovarian Cancer Patients

Iron Metabolism in the Tumor Microenvironment—Implications for Anti-Cancer Immune Response

Circulating proteomic signature for detection of biomarkers in bladder cancer patients

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