The Influence of Pretransplant and Posttransplant Immunosuppression on Cardiac Graft Survival in the Donor-Specific Transfusion Model in Mice

Lasek, W; Jakóbisiak, Marek; Grochowska, Małgorzata; Górecki, Dariusz C.; Gniadecki, Robert; Kaliński, Paweł

doi:10.1097/00007890-198905000-00038

“…Selective lymphoid irradiation combined with antilymphocyte globulin (ALG) was found to delay cardiac allograft rejection with suppression of the CDC level [8]. Cyclosporin A was effective in prolonging cardiac allograft survival in sensitized mice when given after sensitization but before engraftment [13]. Some monoclonal antibodies have also successfully prolonged allograft survival in sensitized recipients, among them: anti-CD8 mAb (YTS 169.4) [14], anti-CD4 mAb (BWH-4) [20], and anti IL-2 receptor mAb (ART-18) [5].…”

Section: Discussionmentioning

confidence: 99%

Sensitization interval and administration method alter the effect of 15-deoxy-spergualin on heart transplantation in sensitized recipient rats

Ueda

¹

,

Itoh

²

,

Iwamoto

³

et al. 1996

Transplant Int

0

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We evaluated the effect of 15-deoxyspergualin (DSG) on accelerated rejection. Brown Norway rats (BN) served as organ donors and Lewis rats (LEW) as recipients. In an accelerated rejection model, after a LEW rat was sensitized with BN skin, a BN heart was transplanted. Various intervals between sensitization and heart transplantation were examined. The heart allografts in sensitized recipients were rejected earlier than those in unmodified recipients regardless of the sensitization interval. DSG (2.5 mg/kg per day), given to the recipients during the sensitization phase, significantly prolonged graft survival compared with the untreated hosts when the sensitization interval was short. When the recipients were treated with DSG after heart transplantation, heart graft survival was significantly prolonged regardless of the sensitization interval. Flow cytometric analysis and complement-dependent cytotoxicity tests revealed that DSG suppressed antidonor antibody formation and the postoperative administration of DSG significantly decreased the proliferation of B cells when the sensitization interval was short and the proliferation of class II antigen-positive cells when the sensitization interval was long.

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Approach to the Highly Sensitized Patient

Chaudhri

¹

,

Nogueira

²

2014

Kidney Transplantation

0

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Sensitization interval and administration method alter the effect of 15-deoxyspergualin on heart transplantation in sensitized recipient rats

Ueda¹,

Itoh²,

Iwamoto³

et al. 1996

View full text Add to dashboard Cite

We evaluated the effect of 15-deoxyspergualin (DSG) on accelerated rejection. Brown Norway rats (BN) served as organ donors and Lewis rats (LEW) as recipients. In an accelerated rejection model, after a LEW rat was sensitized with BN skin, a BN heart was transplanted. Various intervals between sensitization and heart transplantation were examined. The heart allografts in sensitized recipients were rejected earlier than those in unmodified recipients regardless of the sensitization interval. DSG (2.5 mg/kg per day), given to the recipients during the sensitization phase, significantly prolonged graft survival compared with the untreated hosts when the sensitization interval was short. When the recipients were treated with DSG after heart transplantation, heart graft survival was significantly prolonged regardless of the sensitization interval. Flow cytometric analysis and complement-dependent cytotoxicity tests revealed that DSG suppressed antidonor antibody formation and the postoperative administration of DSG significantly decreased the proliferation of B cells when the sensitization interval was short and the proliferation of class II antigen-positive cells when the sensitization interval was long.

show abstract

The Influence of Pretransplant and Posttransplant Immunosuppression on Cardiac Graft Survival in the Donor-Specific Transfusion Model in Mice

Cited by 9 publications

References 0 publications

Sensitization interval and administration method alter the effect of 15-deoxy-spergualin on heart transplantation in sensitized recipient rats

Sensitization interval and administration method alter the effect of 15-deoxy-spergualin on heart transplantation in sensitized recipient rats

Approach to the Highly Sensitized Patient

Sensitization interval and administration method alter the effect of 15-deoxyspergualin on heart transplantation in sensitized recipient rats

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