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Abstract: 1. The effect of modifying potassium intake on arterial plasma renin activity, angiotensin II and aldosterone concentrations, renal blood flow and their responses to exogenous angiotensin II has been assessed in twenty-six normal subjects. 2. Reduced potassium intake was associated with a significant increase in circulating renin activity and angiotensin II concentration and a significant reduction in renal blood flow. Conversely, a high potassium intake was associated with a significant increase in plasma ald… Show more

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Cited by 56 publications
(29 citation statements)
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References 17 publications
(33 reference statements)
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“…Ang II and extracellular K are potent independent regulators of aldosterone production, yet the strength of these agonists in the physiological setting depends on their combined activities and their synergy (11)(12)(13)(14). Small elevations in plasma potassium within the physiological range increase the sensitivity of ZG cells to stimulation by Ang II (13,15).…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Ang II and extracellular K are potent independent regulators of aldosterone production, yet the strength of these agonists in the physiological setting depends on their combined activities and their synergy (11)(12)(13)(14). Small elevations in plasma potassium within the physiological range increase the sensitivity of ZG cells to stimulation by Ang II (13,15).…”
mentioning
confidence: 99%
“…Ang II and extracellular K are potent independent regulators of aldosterone production, yet the strength of these agonists in the physiological setting depends on their combined activities and their synergy (11)(12)(13)(14). Small elevations in plasma potassium within the physiological range increase the sensitivity of ZG cells to stimulation by Ang II (13,15). In this setting, both K and Ang II mediate membrane depolarization of ZG cells (14,16) to enhance the opening of Ang II-modulated, low-voltage-activated, Ca channels (Cav3.2) whose activity underlies the in vivo control of aldosterone production (17,18).…”
mentioning
confidence: 99%
“…Potassium chloride (0.52 meq/ml of normal saline) was infused at a rate of 1 meq/min for 15 min. Blood samples were drawn at -60, -30, -15, -5, and 0 min before potassium infusion, and 5,10,15,30,45 The plasma aldosterone concentration was measured by radioimmunoassay (14), plasma 11-hydroxycorticosteroids by the competitive protein binding method of Murphy (15), and plasma renin activity (PRA)l by the method of Haber et al (16). The plasma potassium concentration was measured using the ion selective electrode procedure of the Astra-8 by Beckman Instrument Co.…”
Section: Methodsmentioning
confidence: 99%
“…Sodium depletion increases aldosterone secretion to a greater extent when subjects are potassium replete than when potassium deplete (2,4,9). Both in vivo and in vitro, potassium augments stimulation by angiotensin II and by ACTH (10)(11)(12). To what extent, if any, this synergism of potassium with other stimuli represents enhancement of potassium's stimulatory capacity by the other stimuli is unknown.…”
Section: As Does Infusion Of Potassiummentioning
confidence: 99%
“…A-11, angiotensin I1 ACTH, adrenocorticotrophin PRA, plasma renin activity Much has been learned about the direct mediators governing aldosterone secretion in adult humans and experimental animals ( 14,18). However, mechanisms regulating aldosterone secretion during fetal life are poorly understood.…”
Section: Abbreviationsmentioning
confidence: 99%