The Influence of Money on Medical Science

Indication of Measures of Uncertainty for Statistical Significance in Abstracts of Published Oncology Trials

“…These results are often conveyed as definitively demonstrating that the null hypothesis of an experiment is false, which may be associated with reliance by the oncology community on a discrete threshold for statistical significance. Many prominent voices in the scientific community are advocating for a change in this culture, and we believe our data support their conclusion …”

“…Many prominent voices in the scientific community are advocating for a change in this culture, and we believe our data support their conclusion. [40][41][42]…”

Issues in the Registration of Clinical Trials

“…Scientific review of trial results by individuals not associated with the research is believed to be critical to ensure accuracy and maintain confidence in the data and subsequent conclusions. 2 Trial results and associated conclusions that are published in peerreviewed literature undergo independent editorial and scientific review. Results that are included in a New Drug Application undergo rigorous review by statisticians and other scientists at the FDA who have access to the complete protocol and raw data.…”

“…Concerns also exist about relying on sponsors or other data providers with vested interests in how the results are portrayed to submit narrative summaries of results. 2 None of the policy proposals under discussion would provide registry staff with access to protocols or raw data, making the independent scientific review of database entries impossible. Without the ability to validate entries, selective reporting of trial results could still occur, thus undermining the key purpose of a results database.…”

Publishing ethics in paediatric research: A cross-cultural comparative review

“…Such information was observed despite disclosing that conflicts of interest information in medical science are worldwide obligations. 6,10,11,[23][24][25] Fourth, the results regarding cross-cultural collaboration in paediatric research might only demonstrate the current uneven proportion of journals indexed in the databases used, their publishing languages or other information, circumstances that were not scrutinized in the present survey. Further conclusions regarding co-authorships within or across-boundaries are not to be expected due to the restrictions just mentioned.…”