2015
DOI: 10.1186/s12936-015-0978-7
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Abstract: BackgroundPolyparasitism is a common condition in humans but its impact on the host immune system and clinical diseases is still poorly understood. There are few studies of the prevalence and the effect of malaria-intestinal parasite co-infections in the immune response to malaria vaccine candidates. The present study determines whether the presence of malaria and intestinal parasites co-infection is associated with impaired IgG responses to Plasmodium vivax AMA-1 and MSP-119 in a rural population of the Brazi… Show more

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Cited by 10 publications
(15 citation statements)
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“…Some studies have explored the effects of helminth co-infections on the dynamics of P . falciparum malaria transmission and its correlation with anaemia [ 26 , 27 ]. In Brazil, recent studies have described the haematological and immunological profiles of vivax malaria and intestinal parasite co-infections [ 25 27 ] in two areas of Brazil's western Amazon.…”
Section: Discussionmentioning
confidence: 99%
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“…Some studies have explored the effects of helminth co-infections on the dynamics of P . falciparum malaria transmission and its correlation with anaemia [ 26 , 27 ]. In Brazil, recent studies have described the haematological and immunological profiles of vivax malaria and intestinal parasite co-infections [ 25 27 ] in two areas of Brazil's western Amazon.…”
Section: Discussionmentioning
confidence: 99%
“…falciparum malaria transmission and its correlation with anaemia [ 26 , 27 ]. In Brazil, recent studies have described the haematological and immunological profiles of vivax malaria and intestinal parasite co-infections [ 25 27 ] in two areas of Brazil's western Amazon. We are the first to study the effect of intestinal parasites on biological aspects of malaria in individuals who were naturally infected with P .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The implications of coinfections in humans evaluated in relation to the effects of intestinal helminth infections on falciparum malaria represent a temporal trend of continuity with variability and epidemiological complexity of each parasite in non - Brazilian endemic areas with conflicting results. In Brazil, studies with patients from the state of Rondônia coinfected with P. vivax and intestinal parasites did not find a direct relationship with anemia [29,30]. Although prevalent coinfection of malaria-intestinal parasites in tropical regions of the planet, little is known about this interaction and its impact on the immune response.…”
Section: Discussionmentioning
confidence: 99%
“…In children, the persistence of antigens may be an important factor for maintenance of antibodies as verified in asymptomatic Gambian children. 23 Based on the low RI verified for both peptides when compared with results obtained in studies using recombinant proteins, [63][64][65] we can speculate that: (a) recombinant proteins are generally composed of a higher number of amino acids and present several conformational epitopes, while peptides are short with probably fewer epitopes available for immunological recognition (14 aa for PvMSP-9 (E795-A808) versus 244aa for PvMSP9-RIRII 729-972 and 18aa for PvAMA-1 (S290-K307) versus 445aa for PvAMA-1 ectodomain); however, the use of peptides in immunological surveys has been validated by studies showing its efficiency in inducing humoral or cellular immunity during vaccine malaria trials 66-68 ; (b) the low endemicity of studied areas reflecting in the low number of previous malaria episodes may be determining in the expression of levels of specific antibodies.…”
Section: Pvmsp-9 (E795-a808)mentioning
confidence: 96%