The Influence of Intensive Hyperbaric Oxygen Therapy on Skin Flap Survival in a Swine Model

Hyperbaric Oxygen Therapy for the Compromised Graft or Flap

“…28 Similar results have been demonstrated in pig models of random flaps: treatment with HBO for 90 min at 2.0 ATA produced a decrease in flap necrosis of 35%. 29…”

“…28 Similar results have been demonstrated in pig models of random flaps: treatment with HBO for 90 min at 2.0 ATA produced a decrease in flap necrosis of 35%. 29 In contrast to random flaps, axial or pedicle flaps contain a direct source artery providing the vascular supply (Fig. 6).…”

A dissolved oxygen dressing: A pilot study in an ischemic skin flap model

“…17 For decades, though, hyperbaric oxygen treatment has been the most common way to increase the oxygen tension in hypoxic tissue in an attempt to improve wound healing. 18 For skin flaps specifically, hyperbaric oxygen therapy improved healing and decreased necrosis in a porcine pedicle flap model 19 and decreased inflammation in a bi-pedicle dermal rat model. 20 Because hyperbaric therapy is not always available or practical in all situations, recent research has sought to deliver oxygen topically, as in a wound dressing.…”

Fibrin‐embedded administration of VEGF plasmid enhances skin flap survival

“…Efforts have therefore been made to improve skin flap survival. Toward this end, surgical delay and treatment with hyperbaric oxygen have been employed with varying degrees of success 5–13 …”