2015
DOI: 10.18632/aging.100763
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Abstract: While the search for genetic contributors to exceptional longevity has yielded candidates, gender differences in inheritance have generally not been considered. The aim of this study was to investigate gender specific differences in the inheritance of exceptional longevity. Using a standardized questionnaire, we assessed the parental ages of death of Ashkenazi Jews with exceptional longevity and their spouses without exceptional longevity, who served as controls (n=1,114). Mothers of centenarian males and fema… Show more

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Cited by 12 publications
(19 citation statements)
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References 22 publications
(29 reference statements)
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“…It is well known that human longevity -with some exception -is strongly correlated with sex, and that females generally live longer than male, likely because of the combination of biological factors (anatomy, reproductive functions, sex hormones, expression of genes on the X or Y chromosome) and social factors related to behaviour, population and peculiar life experiences [66][67][68] as showed in Figure 4. Gender influences also the inheritance of exceptional longevity 69 . The analysis of parental age of a cohort of Ashkenazi Jews with exceptional longevity revealed that in males both maternal and paternal inheritance are likely contributors to exceptional longevity, whereas among females maternal inheritance appears to be more influential 69 .…”
Section: The Genetics Of Human Longevity and Sexual Dimorphismmentioning
confidence: 99%
“…It is well known that human longevity -with some exception -is strongly correlated with sex, and that females generally live longer than male, likely because of the combination of biological factors (anatomy, reproductive functions, sex hormones, expression of genes on the X or Y chromosome) and social factors related to behaviour, population and peculiar life experiences [66][67][68] as showed in Figure 4. Gender influences also the inheritance of exceptional longevity 69 . The analysis of parental age of a cohort of Ashkenazi Jews with exceptional longevity revealed that in males both maternal and paternal inheritance are likely contributors to exceptional longevity, whereas among females maternal inheritance appears to be more influential 69 .…”
Section: The Genetics Of Human Longevity and Sexual Dimorphismmentioning
confidence: 99%
“…Another interesting example concerns the Autophagy-Related Genes (ATG) controlling insulin -insulin receptor-mediated-reactions [20]. Gender-determining genes were also shown to be important mainly in the inheritance of exceptional longevity [21]. Genes designated by the abbreviation INDY (I am not yet dead) which encode the homologs of a mammalian SLC13SA5 pathway (plasma membrane transporter acting on Krebs cycle intermediates, essentially citrate [22].…”
Section: Agingmentioning
confidence: 99%
“…Previous family studies, usually focusing on two generations and single individuals, showed that siblings and children of long‐lived persons lived longer than first‐degree ancestors of non‐long‐lived persons or population controls (Berg, Rodríguez‐Girondo, et al, 2018; Deluty et al, 2015; Dutta et al, 2013; Gudmundsson et al, 2000; Houde et al, 2008; Jarry et al, 2013; Kemkes‐Grottenthaler, 2004; Perls et al, 2002; Schoenmaker et al, 2006; Sebastiani et al, 2016; Terry et al, 2004; Willcox et al, 2006). This knowledge about the familial clustering of longevity was utilized to construct longevity ranking scores such as the Family Mortality History Score (FMHS; Rozing et al, 2010), the est(SE) which subsequently was developed into the FLOSS (Arbeeva et al, 2018; Sebastiani et al, 2009), the Longevity Family Score (LFS) which is an adaptation to the est(SE) and the FMHS (Berg, Rodríguez‐Girondo, et al, 2018), and finally a method was developed to rank individuals by the survival of their ancestors, the FEL score (Kerber et al, 2001).…”
Section: Discussionmentioning
confidence: 99%