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Cited by 20 publications
(5 citation statements)
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References 13 publications
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“…A higher value of TCH,O after infusion of NaCl than of mannitol was also found by GOLDBERG et al (1965). Both these findings and the acceptable fit of all the data in the present study to the relation between TCH,O and Cosm, indicating that TCII,O is affected in the same way by the three contrast media, give further support to the theory that sodium transport in the ascending limb of Henle, necessary for establishing an osmotic concentrating gradient, is dependent on chloride as the specific accompanying anion ( WALLIN et al 1973;IMAI & KOKKO 1974) and not on impermeable anions, as for instance contrast agents.…”
Section: Discussionsupporting
confidence: 89%
“…A higher value of TCH,O after infusion of NaCl than of mannitol was also found by GOLDBERG et al (1965). Both these findings and the acceptable fit of all the data in the present study to the relation between TCH,O and Cosm, indicating that TCII,O is affected in the same way by the three contrast media, give further support to the theory that sodium transport in the ascending limb of Henle, necessary for establishing an osmotic concentrating gradient, is dependent on chloride as the specific accompanying anion ( WALLIN et al 1973;IMAI & KOKKO 1974) and not on impermeable anions, as for instance contrast agents.…”
Section: Discussionsupporting
confidence: 89%
“…During hypertonic saline loading, both normal and hypothyroid rats achieved very high osmolal clearance rates, greater than previously reported in this species (23,(26)(27)(28). As a result, it appears that fractional TCH2o in both groups reached a plateau when Cosm equaled approximately 24% of GFR, as no further increments could be detected even when fractional osmolal clearances were as high as 40-50 ml/min/100 ml GFR.…”
Section: Discussionmentioning
confidence: 61%
“…Similarly, hypothyroid rats increased CH2o appreciably when distal delivery was augmented by benzolamide and acetazolamide, two inhibitors of carbonic anhydrase which decrease proximal sodium reabsorption (11,12,21). It is noteworthy that CH2o rose despite the fact that a considerable proportion of the additional sodium delivered to the diluting segment was probably accompanied by relatively nonreabsorbable bicarbonate (22,23). Demonstration that hypothyroid rats can generate substantially more free water when delivery of filtrate to the diluting segment is increased offers additional support to the hypothesis that reduced distal delivery plays a central role in generating the renal diluting defect in hypothyroidism.…”
Section: Discussionmentioning
confidence: 95%
“…To evaluate this question more explicitly, we assessed the effects of 10-6 M peritubular PGE2 on ADHmediated net Cl-absorption [which, for this tubule segment, is approximately equal to the rate of net NaCl absorption (11), a conclusion also deduced for the in vivo TALH by Wallin et al (54)] under conditions of a constant perfusion rate. These experiments were intended to complement those presented in Fig.…”
Section: Resultsmentioning
confidence: 99%