The influence of family structure, the TPH2 G‐703T and the 5‐HTTLPR serotonergic genes upon affective problems in children aged 10–14 years

Nobile, Maria; Rusconi, Marianna; Bellina, Monica; Marino, Cecilia; Giorda, Roberto; Carlet, Ombretta; Vanzin, Laura; Molteni, Massimo; Battaglia, Marco

doi:10.1111/j.1469-7610.2008.01958.x

Cited by 43 publications

(40 citation statements)

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“…Best-fit solutions from all three computational approaches, however, correspond in suggesting a role for shared environmental factors in affecting the risk for Anxiety and Affective Problems in children aged 8-11 years, consistently with recent epidemiological-, quantitative genetic-, and molecular genetic studies [4,14,33]. Clinicians may therefore pay special attention in assessing the presence of environmental risk/precipitating factors in children who are referred for these disorders.…”

Section: Resultsmentioning

confidence: 99%

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Spatola

Rende

Battaglia

2010

Eur Child Adolesc Psychiatry

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To cite this version:Chiara A. M. Spatola, Richard Rende, Marco Battaglia. Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges. European child & adolescent psychiatry, 2010, 19 (8), pp.647-658. <10.1007/s00787-010-0102-z>. ORIGINAL CONTRIBUTIONGenetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges Abstract Inasmuch as the newly established DSM-oriented CBCL/6-18 scales are to be increasingly employed to assess clinical/high-risk populations, it becomes important to explore their aetiology both within the normal-and the extreme range of variation in general population samples and to compare the results obtained in different age groups. We investigated by the Quantitative Maximum Likelihood, the De Fries-Fulker, and the Ordinal Maximum Likelihood methods the genetic and environmental influences upon the five DSM-oriented CBCL/6-18 scales in 796 twins aged 8-17 years belonging to the general population-based Italian Twin Registry. When children were analysed together regardless of age, most best-fitting solutions yielded genetic and non-shared environmental factors as the sole influences for DSMoriented CBCL/6-18 behaviours, both for the normal and the extreme variations. When analyses were conducted separately for two age groups, shared environmental influences emerged consistently for Affective and Anxiety Problems in children aged 8-11. Oppositional-Defiant, Attention Deficit/Hyperactivity, and Conduct Problems appeared-with few exceptions-influenced only by genetic and non-shared environmental factors in both age groups, according to all three computational approaches. The De Fries-Fulker method appeared to be more sensitive in detecting shared environmental effects. Analysing the same set of data with different analytic approaches leads to better-balanced views on the aetiology of psychopathological behaviours in the developmental years.

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Section: Resultsmentioning

confidence: 99%

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Spatola

Rende

Battaglia

2010

Eur Child Adolesc Psychiatry

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“…Although attending the same school grade, children in the PrISMA sample were slightly older than children in the PL sample, due to a modest difference in the timing of recruitment of the two samples (winter for the PrISMA sample and fall for the PL sample [41,42]). …”

Section: Methodsmentioning

confidence: 99%

“…Since the inclusion (age between 10 and 14 years, parental written informed consent) and exclusion criteria (certification of mental handicap, which was present in 0.3% of eligible participants) and the psychometric instrument (parental assessments of children behaviour through the CBCL/6-18) were the same for the PrISMA and the PL samples, after controlling for the homogeneity of demographic and behavioural variables, as in two previous studies regarding externalizing behaviour and affective problems [41,42], for the present study we pooled together subjects of both epidemiological samples to increase the statistical power.…”

Section: Methodsmentioning

confidence: 99%

“…Previous controls for biases performed upon demographic and behavioural variables showed no, or only modestly significant differences in behavioural variables in children belonging to families who agreed versus those belonging to families who did not agree to participate in the genetic study [41,42]. Moreover, there were no significant differences owing to SES (t = -0.72, p = 0.47) or age (t = -1.34, p = 0.18) between PrISMA children belonging to families who agreed versus those belonging to families who did not agree to participate in the genetic study [41].…”

Section: Statistical Analysesmentioning

confidence: 99%

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COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperactivity problems in children aged 10–14

Nobile

Rusconi

Bellina

et al. 2009

Eur Child Adolesc Psychiatry

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The functional Val158Met COMT polymorphism appears to affect a host of behaviours mediated by the pre-frontal cortex, and has been found associated to the risk for disruptive behaviours including ADHD. Parental socioeconomic status (SES) has also been reported as a predictor for the same childhood disorders. In a general population sample of 575 Italian pre-adolescents aged 10-14, we examined the association of the functional Val158Met COMT polymorphism and SES-both as linear and interactive effects-with oppositional defiant problems, conduct problems, and attention deficit/hyperactivity problems, as defined by the newly established Child Behaviour Check-List/6-18 DSM oriented scales. Multivariate-and subsequent univariate-analysis of covariance showed a significant association of COMT 9 SES interaction with CBCL 6/18 DOS attention deficit/hyperactivity problems (p = 0.004), and revealed higher scores among those children with Val/Val COMT genotype who belonged to low-SES families. We also found a significant association of SES with attention deficit/hyperactivity problems and conduct problems DOS (p = 0.04 and 0.01, respectively). Our data are consistent with a bulk of recent literature suggesting a role of environmental factors in moderating the contribution of specific genetic polymorphisms to human variability in ADHD. While future investigations will refine and better clarify which specific environmental and genetic mechanisms are at work in influencing the individual risk to ADHD in pre-adolescence, these data may contribute to identify/prevent the risk for ADHD problems in childhood.

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“…Nobile et al, 2008;Campbell et al, 2013;Chen, Li, & McGue, 2013;Cents et al, 2014). Some considerations on which JCPP's decisions whether to accept or reject reports of trait/disorder-gene association may guide authors when planning their studies; however, under certain circumstances other types of studies might add value and may be acceptable too.…”

mentioning

confidence: 99%

Editorial: Illuminating the dark matter of developmental neuropsychiatric genetics – strategic focus for future research in child psychology and psychiatry

Lesch¹

2014

Child Psychology Psychiatry

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Research on genetic factors influencing cognitive and behavioural traits or which are central to the aetiology of neuropsychiatric diseases has been complicated by a furtive discrepancy between high heritability estimates and a scarcity of replicable gene‐disorder associations. This ‘missing heritability’ has been either euphemised as the ‘dark matter’ of gene‐trait association or aggravated as the ‘looming crisis in behavioural genetics’. Nevertheless, in recognising the importance of this topic for our understanding of child psychiatric conditions and highlighting its commitment to the field, the Journal of Child Psychology and Psychiatry (JCPP) has for the first time appointed an editor with special responsibility for molecular (epi)genetics.

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The influence of family structure, the TPH2 G‐703T and the 5‐HTTLPR serotonergic genes upon affective problems in children aged 10–14 years

Cited by 43 publications

References 45 publications

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

Genetic and environmental influences upon the CBCL/6-18 DSM-oriented scales: similarities and differences across three different computational approaches and two age ranges

COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperactivity problems in children aged 10–14

Editorial: Illuminating the dark matter of developmental neuropsychiatric genetics – strategic focus for future research in child psychology and psychiatry

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